Molecular delineation, immune modulation analysis, and antioxidant functional assessment of catalase (CAT) from chub mackerel (Scomber japonicus).

Cytotoxic reactive oxygen species (ROS), including hydroxyl radicals (OH), superoxide anions (O), peroxides (O), and nitrogen radicals (NO), are derivatives of hydrogen peroxide (HO). Catalase (CAT) is an immunologically important antioxidant enzyme that regulates host redox homeostasis by disintegrating cellular HO into water and oxygen. The identified CAT homolog sequence from Scomber japonicus (SjCAT) comprised 1584 bp, encoding 527 amino acids in length with a molecular weight of 59.

Severe Bradyarrhythmia and Reduced Cardiac Output Due to Oral Baclofen Withdrawal in a 24-Year Old Man: A Case Report.

BACKGROUND Baclofen is a selective gamma-aminobutyric acid (GABA) receptor agonist and muscle relaxant prescribed to treat spasticity and muscle pain and is used off-label to treat alcohol use disorder and gastroesophageal reflux disease. Baclofen withdrawal syndrome is a rare condition that presents with abnormal cardiac rhythm and function. This report describes the case of a 24-year-old man who presented with polypharmacy overdose, including baclofen, who subsequently showed features of baclofen withdrawal, requiring baclofen reintroduction.

POCUS to Diagnose a Large Urethral Stone Causing Urinary Retention: A Case Report.

Background: Ultrasound is routinely used in the diagnosis of renal calculi and resulting hydronephrosis. However, its utility in the diagnosis and management of urethral calculi is less well understood. The ability to rapidly diagnose urethral calculi using point of care ultrasound (POCUS) would be useful in the emergency department (ED) to improve patient outcomes and avoid more invasive investigations.

Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion.

Neuropsychiatric disorders remain difficult to treat due to complex and poorly understood mechanisms. NeuroPainting is a high-content morphological profiling assay based on Cell Painting and optimized for human stem cell-derived neural cell types, including neurons, progenitors, and astrocytes. The assay quantifies over 4000 features of cell structure and organelle organization, generating a dataset suitable for phenotypic screening in neural models.

From ADAS to Material-Informed Inspection: Review of Hyperspectral Imaging Applications on Mobile Ground Robots.

Hyperspectral imaging (HSI) has evolved from its origins in space missions to become a promising sensing technology for mobile ground robots, offering unique capabilities in material identification and scene understanding. This review examines the integration and applications of HSI systems in ground-based mobile platforms, with emphasis on outdoor implementations. The analysis covers recent developments in two main application domains: autonomous navigation and inspection tasks.