Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice.

Background And Purpose: Migraine is a neurovascular disorder largely mediated by calcitonin gene-related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)-N/OFQ receptor (NOP) system in CGRP-induced periorbital mechanical allodynia (PMA) in mice.

Experimental Approach: Male or female wild type (NOP(+/+)) and NOP receptor knockout (NOP(-/-)) mice and CD-1 mice were used.

Prevalence and concordance of cardiometabolic risk markers and health behaviour among couples after a gestational diabetes mellitus-affected pregnancy.

Aims: This study investigated the prevalence and concordance of cardiometabolic risk markers among couples after a gestational diabetes mellitus (GDM)-affected pregnancy. It also examined whether selected demographic, socioeconomic and health behavioural factors could explain within-couple associations.

Materials And Methods: A cross-sectional study design was used.

Neural responses to visual food cues according to weight and hunger state: A systematic review and meta-analysis.

Background: Food cue reactivity shapes eating behavior and likely relates to weight and hunger states. Functional Magnetic Resonance Imaging (fMRI) studies, however, have yielded mixed results on the underlying neural correlates. We, therefore, conducted a systematic review and meta-analysis to investigate the effect of weight and hunger on neural responses to food cues.