Choosing a nonsteroidal anti-inflammatory drug for pain.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are useful for many conditions, frequently in preference to other therapies such as opioids. They play an important role in osteoarthritis, headache disorders, acute musculoskeletal injury, dysmenorrhoea and dental pain. In axial spondyloarthritis, they can modify disease and represent first-line therapy.

Productivity Losses Due to Long-Term Back Problems in Working-Age Australians.

Importance: Long-term back problems impact an individual's ability to participate in the workforce productively, potentially resulting in financial stress and furthering inequities. Estimates of future productivity losses could inform advocacy and policy making.

Objective: To estimate the productivity losses of long-term back problems in working-age Australians (aged 15-64 years) over the next 10 years (2024-2033).

Long-Term Safety of Anti-Interleukin-1 Medications in Children with Rheumatic Diseases: a Systematic Review.

Background: Anti-interleukin-1 (IL-1) biologic disease-modifying anti-rheumatic drugs are the mainstay for several childhood rheumatic and autoinflammatory diseases. Long-term medication safety is a key consideration for chronic disease management.

Aim: The objective was to synthesise evidence on the long-term safety of anti-IL-1 medications in children and young people with rheumatic diseases, including autoinflammatory diseases.

Painfully Obvious? Non-Operative Drivers of Post-Operative Pain and Opioid Exposure in a Predominantly Emergency Surgical Cohort: A Multicentre Observational Study Identifying Non-Operative, Perioperative Pain Correlates.

Introduction: There are many non-operative factors (patient specific and management strategies) that are ubiquitous across all surgeries, which may influence perioperative pain. Recognition of these factors and their association with pain and analgesia requirements could provide avenues for improved perioperative care.

Methods: All consecutive surgical patients admitted to six Australian tertiary hospitals (2017-2024) were included.

Medication persistence trajectories among individuals prescribed lipid-lowering therapy in primary care settings: A retrospective cohort study.

Aims: This study aimed to identify distinct trajectories of lipid-modifying medication (LMM) persistence over time and to explore characteristics associated with each pattern.

Methods: Using primary care data from IQVIA, we conducted a retrospective cohort study of adults prescribed LMMs between January 2015 and December 2017, with 5 years of follow-up. Persistence was defined as ≥1 prescription every 6 months.