Phytochemical innovations in oral cancer therapy: targeting oncogenic pathways with natural compounds.

Oral squamous cell carcinoma (OSCC) remains a significant global health concern due to its high mortality rate, late-stage diagnosis, and limited treatment options. Conventional therapies such as surgery, radiotherapy, and chemotherapy often face limitations including drug resistance, recurrence, and systemic toxicity, prompting the need for alternative strategies. This narrative review synthesizes recent preclinical evidence on the use of natural phytochemicals including alkaloids, flavonoids, tannins, saponins, and terpenoids for OSCC treatment.

Impact of Soil Microbiomes on Mung Bean Cultivation: Insights from 16S rRNA Metagenomics.

Cyclic nutrient processes, soil health maintenance, and plant development are contingent upon soil microbiomes. The microbial makeup of the soil of Maruthupandiyar College, Thanjavur, is assessed using 16S rRNA gene sequencing. QIIME2, in conjunction with the SILVA database, analyzed the sequencing data to examine microbial diversity and composition.

Individualized Homeopathic Medicines in the Treatment of Psoriasis Vulgaris: Double-Blind, Randomized, Placebo-Controlled Trial.

Introduction: Psoriasis is a chronic inflammatory skin disorder, affecting the trunk and extensor surfaces of the limbs and scalp predominantly. Worldwide prevalence ranges between 0.1 and 11.

Modeling of ACE2 and antibodies bound to SARS-CoV-2 provides insights into infectivity and immune evasion.

Given the COVID-19 pandemic, there is interest in understanding ligand-receptor features and targeted antibody-binding attributes against emerging SARS-CoV-2 variants. Here, we developed a large-scale structure-based pipeline for analysis of protein-protein interactions regulating SARS-CoV-2 immune evasion. First, we generated computed structural models of the Spike protein of 3 SARS-CoV-2 variants (B.

Individualized Homeopathic Medicines for Low Back Pain in Lumbar Spondylosis: Double-Blind, Randomized, Placebo-Controlled Trial.

Introduction: Lumbar spondylosis (LS) is a degenerative disorder of the lumbar spine. Despite substantial research efforts, no gold-standard treatment for LS has been identified. The efficacy of individualized homeopathic medicines (IHMs) in LS has remained under-researched.