Substance P mitigates lipopolysaccharide induced cognitive impairment in rats in a dose dependent manner.

Neuroinflammation contributes to cognitive decline in Alzheimer's disease (AD), and the neurokinin pathway has been implicated in the pathophysiology of AD. Although Substance P (SP), an endogenous ligand to the neurokinin 1 receptor (NK1R), is primarily known as a neurotransmitter, but emerging evidence indicates it has shown both pro and anti-inflammatory actions. However, the dose-dependent nature of the SP-NK1R axis's functional role remains to be fully elucidated.

Comparison of bacterial colonization of implant abutment internal recess in internal hex and conical connection implants: An in vivo prospective study.

Aim: Microbial assessment of internal recess of two different internal implant connections in an in vivo study.

Study Settings And Design: This randomized, in vivo study included 40 patients requiring mandibular single-tooth implant-supported prostheses, allocated into two equal groups based on implant connection design.

Materials And Methods: Group Internal Hex (IH) and group Conical Connection (CC) received implants with IH and CC, respectively.

The Effect of Different File Motions on the Formation of Apical Debris During Root Canal Preparation.

Background: The formation of apical debris is a common occurrence during root canal preparation, which may cause postoperative complications like pain and infection. Different file motions-rotary, reciprocating, and adaptive-can influence the extent of debris extrusion.

Materials And Methods: A total of 90 extracted single-rooted teeth were randomly divided into three groups ( = 30) based on the file motion used: Group 1-rotary, Group 2-reciprocating, and Group 3-adaptive motion.

Ayurvedic Treatment in the Rehabilitation of Ischemic Stroke Patients in India: A Randomized Controlled Trial (RESTORE) - Findings from the Process Evaluation.

Introduction: The RESTORE trial was the first randomized controlled trial comparing two systems of medicine in stroke. The trial studied about the safety and efficacy of ayurvedic rehabilitative treatment in comparison with conventional physiotherapy in stroke rehabilitation across North and South India. The results showed that ayurvedic rehabilitative treatment was not superior to conventional physiotherapy for improving sensorimotor recovery in ischemic stroke patients, but it was safe to use.

An Assessment of Microleakage of Pit and Fissure Sealants and Restorative Materials Using Dye Penetration Method.

Aim: The study focused to determine the microleakage of various materials using the dye penetration method.

Materials And Methods: The study samples consisted of 45 healthy human mandibular premolar teeth removed for orthodontic therapy without caries. The samples were categorized into three groups of 15 each.