Plasma transfusion practice: A five-year audit of plasma transfusion at 23 hospitals.

Background: There is limited high-quality evidence to guide plasma transfusion, and plasma transfusion practices remain variable.

Study Design And Methods: This is a retrospective cohort study that included adult medical and intensive care unit (ICU) inpatients (age ≥ 18 years) admitted to 23 hospitals in Canada between January 1, 2017, and December 31, 2022, when both whole blood derived (~290 mL) and apheresis plasma (~250 mL) were available for transfusion. Nine additional hospital sites with missing plasma data or coagulation testing were excluded.

Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia.

Background: Heparin-induced thrombocytopenia (HIT) is an immune-mediated platelet disorder caused by antibodies that target complexes of platelet factor 4 (PF4) and heparin. HIT has been characterized as a polyclonal immune response; however, studies of other rare anti-PF4 disorders have identified clonally restricted antibodies.

Methods: In this study, we investigated the clonality of pathogenic HIT antibodies.

Managing Mental Health Crisis Calls Received by a US Poison Center: A Statewide Collaboration Between the Georgia Poison Center, 911, and 988.

The Georgia Poison Center developed a protocol for managing mental health crisis cases via iterative feedback with Georgia 911-related emergency medical services and Georgia 988-related mental health services. The Georgia Poison Center managed 533 such cases in 2024 (the year of protocol implementation), of which 45 (8.4%) were transferred to 911.

Usefulness and Limitations of Polymerase Chain Reaction (PCR) for the Diagnosis and Management of Toxoplasmosis Following Allogeneic Hematopoietic Cell Transplant: Single-center Experience With 31 Patients Over 16 Years.

Background: Toxoplasmosis is an early post-transplant complication in recipients of allogeneic hematopoietic cell transplant (HCT), typically arising from reactivation of latent infection. polymerase chain reaction (PCR) has improved detection.

Methods: Single-center, retrospective review of allogeneic HCT recipients who developed toxoplasmosis from August 2008 to November 2024.