Innovative imaging-based pre-operative planning for correction of proximal femur malunion with implants in-situ using and PowerPoint.

Background: Proximal femoral malunions with implants in-situ pose a significant challenge for pre-operative planning due to the obstruction of key anatomical landmarks. Existing planning software, while advanced, is often limited by cost, accessibility and a lack of functionality for digital implant removal. The main objective is to introduce a novel, low-cost and accessible two-step digital method for planning deformity correction using Picsart and Microsoft PowerPoint.

Comparative analysis of uterine flora in pregnant women undergoing elective and non-elective caesarean section of central Uttar Pradesh, India.

Context: The incidence rate of puerperal infection caused by uncommon pathogenic bacteria has risen. Thus, we sought to analyse uterine flora in patients of elective and non-elective caesarean section.

Aims: (1) To compare uterine flora in elective and non-elective caesarean section.

The association between Dietary Obesity-Prevention Score (DOS) and type 2 diabetes (T2D): a case-control study.

Background: The global prevalence of type 2 diabetes (T2D) continues to rise, with dietary patterns recognized as a major contributing factor in its development. The Dietary Obesity-Prevention Score (DOS) is a validated tool designed to evaluate adherence to dietary behaviors associated with obesity prevention. This case-control study aimed to examine the association between adherence to the DOS and the risk of developing T2D.

The histone-methyltransferase DOT1L cooperates with LSD1 to control cell division in blast-phase MPN.

Persistence of JAK2-mutated clones that may undergo clonal evolution and malignant transformation remains a challenge in myeloproliferative neoplasms (MPN), Novel therapeutic approaches to attenuate clonal evolution and progression to blast-phase are therefore urgently needed. LSD1 (KDM1A) inhibitors reduce symptoms and clonal burden in MPN, but whether these compounds may be effective in advanced disease stages remained so far elusive. Using a chromatin-focused CRISPR-Cas9 screen, we identified the histone methyltransferase DOT1L as a synthetic lethal target under pharmacologic LSD1 inhibition.

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication.

Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we generated comparative PPI maps for SARS-CoV-2 and its bat-origin relative RaTG13 using affinity purification-mass spectrometry (AP-MS) in human and (RFe) bat cells. This approach identified both conserved and virus- and host-specific interactions that regulate infection dynamics.