Overexpression of Gα in Murine Osteoblasts In Vivo Leads to Increased Bone Mass and Decreased Bone Quality.

Gα is a heterotrimeric G protein that transduces signals from activated G protein-coupled receptors on the cell surface to stimulate adenylyl cyclase/cyclic adenosine monophosphate (AMP) signaling. Gα plays a central role in mediating numerous growth and maintenance processes including osteogenesis and bone turnover. Decreased Gα expression or activating mutations in Gα both affect bone, suggesting that modulating Gα protein levels may be important for bone health and development.