Publications by authors named "Clement Goubault"
Drug nanocapsules coated with iron oxide nanoparticles (SPION) were elaborated by the simultaneous nanoprecipitation of the drug and the nanoparticles, through solvent shifting. We examined four drugs: sorafenib, sorafenib tosylate, α-tocopherol and paclitaxel, to cover the cases of molecular solids, ionic solids, and molecular liquids. We first investigated the formation of the drug core in the final mixture of solvents at different concentrations.
View Article and Find Full Text PDFShedding light on the formation and stability of mesostructures in ternary "Ouzo" mixtures.
J Colloid Interface Sci
March 2023
Article Synopsis
- The study investigates how certain mixtures of water, solvents, and hydrophobic solutes create particles through the "Ouzo effect" and form stable microemulsions, highlighting variability in defining the “Ouzo domain.”
- The research involves analyzing four different systems and utilizing various methods, like DLS and NMR, to create detailed phase diagrams.
- Key findings reveal that the transition to the Ouzo domain doesn't align with expected cloudiness and can appear transparent; it is better characterized by stability analysis rather than cloudiness curves, with particles being stabilized by a high negative charge.
Glioblastoma remains a cancer for which the effectiveness of treatments has shown little improvement over the last decades. For this pathology, multiple therapies combining resection, chemotherapy and radiotherapy remain the norm. In this context, the use of high-Z nanoparticles such as gold or hafnium to potentiate radiotherapy is attracting more and more attention.
View Article and Find Full Text PDFParticles stabilize fluid interfaces. In particular, oil/water Pickering emulsions undergo limited coalescence, yielding droplets of smaller size as the amount of particles is increased. Herein, we studied the effect of hydrophobic nanoparticles (<10 nm, alkyl-coated) on submicronic droplets (ca 100 nm) formed in an Ouzo system.
View Article and Find Full Text PDFArticle Synopsis
- This research explores hybridosomes®, unique capsules made from inorganic nanoparticles and polymers, created through a simple emulsification process using THF, water, and BHT.
- A significant finding is that these capsules can hold a high concentration of a hydrophobic dye, reaching up to 0.35 mol/L, which amounts to about 170 g/L or approximately 450,000 dye molecules per capsule.
- The study also reveals the encapsulation mechanism and shows that the dye can be transferred to liposomes and diffuses throughout the body, where it accumulates in fat, while the nanoparticles remain trapped in the liver and spleen.