Comprehensive transcriptomic analysis of the hypothalamic-pituitary-ovarian axis reveals the role of Aurora Kinase B in regulating follicular granulosa cell development and steroid hormone synthesis in Wuding chickens.

Wuding chicken, an indigenous avian breed native to China, is known for its high-quality meat and eggs. However, it has a low egg production rate, poor reproductive traits, and strong broody behavior. Ovarian follicle development is essential for egg production and reproduction, being regulated by the hypothalamus-pituitary-ovary (HPO) axis.

Cardiovascular Risk and Safety Evaluation of a Dual Peroxisome Proliferator-Activated Receptor-Alpha/Gamma Agonist, Aleglitazar, in Patients With Type 2 Diabetes: A Meta-analysis.

This study evaluates the cardiovascular risk and safety of a dual peroxisome proliferator-activated receptor alpha and gamma (PPARα&γ), aleglitazar, for the management of type 2 diabetes mellitus. Studies were identified after a literature search in electronic databases and included in the meta-analysis according to eligibility criteria. Meta-analyses of mean differences in the changes from the baseline or odds ratios of selected indices between the aleglitazar- and the placebo/comparator-treated participants were performed.

Hemodynamic effect of apelin in a canine model of acute pulmonary thromboembolism.

The peptide apelin is expressed in the pulmonary vasculature and is involved in the pathogenesis of many cardiovascular diseases. It has a biphasic role in the regulation of vasomotor tone related to the vascular endothelium. In this study, we induced acute pulmonary embolism (APE) in dogs with autologous blood clots to assess the effect of apelin on pulmonary and systemic circulation in the acute phase of APE.