A retrospective analysis of combination therapy with GLP-1 receptor agonists and SGLT2 inhibitors versus SGLT2 inhibitor monotherapy in patients with MASLD.

The impact of adding glucagon-like peptide-1 receptor agonists (GLP-1RAs) to sodium-glucose co-transporter-2 inhibitors (SGLT2is) for metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear. This retrospective study compared the effect of GLP-1RA plus SGLT2i versus SGLT2i alone for MASLD. Combination therapy was associated with a lower risk of primary composite outcomes of all-cause hospitalization, all-cause mortality, major adverse cardiovascular events (MACE), major adverse kidney events (MAKE), and major adverse liver outcomes (MALO) (hazard ratio [HR], 0.

Impact of prior COVID-19 vaccination on major adverse kidney events in patients with non-dialysis dependent chronic kidney disease: a global retrospective study.

Background: Vaccination prevents complications and death in patients with chronic kidney disease (CKD) and COVID-19, but concerns remain about post-vaccination kidney outcomes. This study assessed the real-world impact of prior COVID-19 vaccination on major adverse kidney events (MAKEs) in CKD patients with COVID-19.

Research Design And Methods: We conducted a global retrospective cohort study using the TriNetX database from 1 January 2020, to 31 May 2024.

Comparative effectiveness of tirzepatide versus bariatric metabolic surgery in adults with metabolic-associated steatotic liver disease and obesity: a multi-institutional propensity score-matched study.

Objective: This study compared the clinical outcomes of tirzepatide versus bariatric metabolic surgery (BMS) in adults with metabolic-associated steatotic liver disease (MASLD) and obesity.

Methods: A retrospective cohort analysis was conducted using the TriNetX Global Collaborative Network. Patients with MASLD and obesity were stratified into tirzepatide and BMS groups.

Impact of body mass index on outcomes of non-cystic fibrosis bronchiectasis.

Background: Low body mass index (BMI) is associated with poor prognosis in patients with non-cystic fibrosis (non-CF) bronchiectasis. However, the impact of being overweight or obese on clinical outcomes of these patients remains controversial.

Materials And Methods: This retrospective cohort study was conducted using TriNetX.

Incident obstructive sleep apnea in patients with primary aldosteronism following COVID-19 infection: a health global federated network analysis.

Background: In the context of the COVID-19 pandemic, there is growing concern about the virus's effects on individuals with existing endocrine disorders such as primary aldosteronism (PA).

Objectives: This study explores the potential relationship between PA and the risk of developing obstructive sleep apnea (OSA) after a COVID-19 infection.

Design: In this retrospective cohort study, we utilized data from the TriNetX database, covering the period from January 2019 to January 2023.

The clinical effectiveness of sodium-glucose co-transporter-2 inhibitors on prognosis of patients with chronic obstructive pulmonary disease and diabetes.

Diabetes is common in patients with chronic obstructive pulmonary disease. Sodium-glucose co-transporter-2 inhibitors are effective in treating type 2 diabetes and provide benefits for conditions like cardiovascular and kidney diseases. We use data from multiple institutions and countries to evaluate their role in patients with chronic obstructive pulmonary disease and diabetes.

Resurgence of human metapneumovirus in the post-COVID-19 era: pathogenesis, epidemiological shifts, clinical impact, and future challenges.

Human metapneumovirus (hMPV), a respiratory pathogen identified in 2001, is a substantial cause of community-acquired respiratory infections across all age groups. This Review explores the impact of hMPV after the COVID-19 pandemic, emphasising its resurgence as a public health concern. Epidemiological shifts, as well as unusual seasonal patterns, increased co-infection rates, and altered age distributions, have been observed globally.

Semaglutide versus other GLP-1 receptor agonists in patients with MASLD.

Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide. While glucagon-like peptide-1 receptor agonists (GLP-1RAs) show promise in MASLD treatment, the comparative effectiveness of semaglutide versus other GLP-1RAs remains unclear. This study aimed to compare clinical outcomes between semaglutide and other GLP-1RAs in patients with MASLD.

Impact of Bariatric Metabolic Surgery on Cardiovascular, Kidney, and Mortality Outcomes Among Adults with Obesity and Chronic Kidney Disease Across Different Time Frames.

Objective: Bariatric metabolic surgery (BMS) is an effective intervention for obesity, with proven benefits in reducing cardiovascular events and mortality. However, its impact on patients with chronic kidney disease (CKD) remains unclear. This study aims to evaluate the long-term outcomes of BMS compared to nonsurgical management in CKD patients with obesity, focusing on major adverse cardiovascular events (MACE), major adverse kidney events (MAKE), and all-cause mortality.

Liberal vs restrictive transfusion strategy for acute brain injury: A meta-analysis with trial sequential analysis of randomized clinical trials.

Background: Acute brain injury is a critical health challenge with substantial mortality and morbidity. While anemia is common in these patients and may worsen outcomes, the optimal red blood cell transfusion strategy remains controversial.

Objective: We conducted a meta-analysis with trial sequential analysis of randomized controlled trials (RCTs) comparing liberal versus restrictive transfusion strategies in patients with acute brain injury.

Clinical outcomes and safety of 7-day versus 14-day antibiotic therapy for bloodstream infections in adults: A systematic review and meta-analysis with trial sequential analysis.

The optimal duration of antibiotic therapy for bloodstream infections (BSIs) remains uncertain. This meta-analysis with trial sequential analysis (TSA) compared the efficacy and safety of 7-day versus 14-day antibiotic courses in adults. A systematic search of PubMed, Embase, and Cochrane Library identified four randomized controlled trials (4794 patients).

Glucagon-like peptide-1 receptor agonists and gastrointestinal cancer risk in individuals with type 2 diabetes.

Aims/hypothesis: Although benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been demonstrated in treatment of type 2 diabetes and weight management, their potential role in cancer prevention remains inadequately explored.

Methods: Using the TriNetX Research Network, we conducted a retrospective cohort study comparing new users of GLP-1RAs with users of other glucose-lowering medications. Propensity score matching was performed for demographic factors, socioeconomic factors, family history, lifestyle factors and cancer risk factors.

Comparative clinical outcomes of adults with obstructive sleep apnea and comorbid obesity receiving tirzepatide versus bariatric metabolic surgery: A Multi-Institutional propensity score matched study.

Objective: This study compared clinical outcomes of tirzepatide versus bariatric metabolic surgery (BMS) in adults with obstructive sleep apnea (OSA) and obesity.

Methods: A retrospective cohort analysis was conducted using the TriNetX Global Collaborative Network. Patients with OSA and comorbid obesity were stratified into tirzepatide and BMS groups.

Clinical effectiveness of oral antiviral treatment for non-hospitalized high-risk patients with COVID-19 during Omicron JN.1 subvariant wave: a US-based propensity-matched cohort study.

Background: This real-world study aimed to assess the effectiveness of novel oral antiviral agents in managing COVID-19 among high-risk patients during the Omicron JN.1 subvariant wave.

Methods: Data from the TriNetX US network were analyzed using a multi-institutional propensity score matching (PSM) analysis.

Effectiveness of tirzepatide in patients with HFpEF using a target trial emulation retrospective cohort study.

Tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has shown promise in improving metabolic and cardiovascular profiles in patients with obesity. However, its potential benefits in patients with heart failure with preserved ejection fraction (HFpEF) remain unclear. We conducted a real-world, retrospective cohort study using the TriNetX global database.

Mortality and cardiorenal outcomes among heart failure patients with zinc deficiency: a multicenter retrospective cohort study of 8,290 patients.

Objective: This study aimed to examine the association between zinc deficiency (ZD) and the clinical outcomes in patients with heart failure (HF).

Methods: This multicenter retrospective cohort study used the TriNetX network to identify adult patients with HF between January 1, 2010, and January 31, 2025. Patients with serum zinc levels below 70 μg/dL (ZD group) were propensity score-matched to those with levels between 70 and 120 μg/dL (control group) to minimize confounding.