Energy ratio controlled gate-tuning four-wave mixing in monolayer graphene.

Monolayer graphene, with a gapless conical electronic band structure, demonstrates scale invariance, showing universal linear optical responses. The impacts of this feature on nonlinear optical responses remain unclear. Our work reveals that the gate-tunable difference-frequency four-wave mixing (DFM) responses in monolayer graphene are significantly influenced by the energy ratios between excitation photons.

The type VI secretion system as a potential predictor of subsequent bloodstream infection of carbapenem-resistant Klebsiella pneumoniae strains on intestinal colonization.

Background: The type VI secretion system (T6SS) has been recognized as a novel virulence factor in Klebsiella pneumoniae. This study investigated the occurrence of T6SS genes in carbapenem-resistant Klebsiella pneumoniae (CRKP) strains during intestinal colonization and evaluated their effect on the development of bloodstream infections.

Methods: The study encompassed 2,385 patients admitted to the intensive care unit (ICU) and subjected to routine screening for intestinal colonization with CRKP.

Role of salvianolic acid B in the treatment of acute ischemic stroke: a systematic review and meta-analysis of animal models.

Background: Salvianolic acid B (Sal B) is potentially the most valuable water-soluble active component in Salvia miltiorrhiza. Its chemical formula contains multiple phenolic hydroxyl groups, so it has a strong antioxidant capacity.

Objective: We aim to investigate the efficacy and the potential mechanism of Sal B in the treatment of acute ischemic stroke injury.

Huoluo Xiaoling Pellet promotes microglia M2 polarization through increasing MCPIP1 expression for ischemia stroke alleviation.

Huoluo Xiaoling Pellet (HXP), a Chinese patent medicine, is commonly administered for the treatment of treat ischemic strokes. MCPIP1, an inducible suppressor of the inflammatory response, is a regulator of microglial M2 polarization. This study aimed to explore whether HXP can promote microglial M2 polarization by upregulating MCPIP1 expression, consequently mitigating cerebral ischemic injury.

Research progress on circulating tumor cells of hepatocellular carcinoma.

Circulating tumor cells (CTCs) are the cells released from the primary tumor and found in the peripheral blood, which can colonize and develop at a distance through blood circulation. At present, the commonly used separation and detection methods of CTCs are mainly divided into physical methods, biological methods, and microfluidic chip-based methods. Monitoring CTC count and cell phenotype is of great significance for early screening and diagnosis of hepatocellular carcinoma (HCC).