Publications by authors named "Cheng-Jen Chen"

Background: The observational study examines the evolution of emergency medicine residency programs in Taiwan, comparing key program attributes between 2003 and 2021. To identify significant changes in emergency medicine resident program structure, educational resources, and operational aspects.

Methods: According to the previous study carried out in 2003, we conducted a comprehensive analysis of 22 specified items across four domains: contact information, training content, faculty and research, and patient care and benefits, comparing key program attributes between 2003 and 2021.

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  • The study investigates and compares characteristics of autoimmune liver diseases (AILDs), specifically primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and PBC-AIH overlap syndrome (OS) in an Asian population.
  • It shows that PBC patients are older, have higher female-to-male ratios, and exhibit greater rates of complications such as cirrhosis and dyslipidemia compared to AIH patients, with notable differences in liver function markers and mortality rates.
  • The research emphasizes the need for special attention to older PBC patients, particularly females with obesity, due to their higher risks of liver complications and hepatocellular carcinoma (HCC).
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Introduction: A deep learning algorithm to quantify steatosis from ultrasound images may change a subjective diagnosis to objective quantification. We evaluate this algorithm in patients with weight changes.

Materials And Methods: Patients (N = 101) who experienced weight changes ≥ 5% were selected for the study, using serial ultrasound studies retrospectively collected from 2013 to 2021.

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Background: Acoustic radiation force impulse (ARFI) is used to measure liver fibrosis and predict outcomes. The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus (HBV) than in other etiologies of chronic liver disease.

Aim: To evaluate the performance of ARFI in long-term outcome prediction among different etiologies of chronic liver disease.

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Background And Aim: World Health Organization sets up an ambitious and attainable goal to eliminate hepatitis C (HCV) by 2030. The previous diagnosed HCV patients lost to follow-up were considered as an important target group for HCV elimination. We conducted a call back program to retrieve the lost to follow-up HCV patients and link them to care in our hospital.

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Background: Hepatic steatosis is a major cause of chronic liver disease. Two-dimensional (2D) ultrasound is the most widely used non-invasive tool for screening and monitoring, but associated diagnoses are highly subjective.

Aim: To develop a scalable deep learning (DL) algorithm for quantitative scoring of liver steatosis from 2D ultrasound images.

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A record outbreak of community-spread COVID-19 started on 10 May 2021, in Taiwan. In response to the COVID-19 pandemic, care facilities have adopted various protocols using instant communication technology (ICT) to provide remote yet timely healthcare while ensuring staff safety. The challenges of patient evaluation in the emergency department (ED) using ICT are seldom discussed in the literature.

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Background/purpose: The rates and outcomes of primary biliary cholangitis (PBC) in Taiwan remain unclear.

Methods: A nationwide population-based cohort study (Taiwan National Health Insurance Research Database, 2002-2015) was conducted. Data from four PBC cohorts with various definitions were compared (cohort 1 (C1): ICD-9-CM (571.

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  • The study investigates the role of JMJD5, a histone demethylase, in tumor growth and metastasis for patients with oral squamous cell carcinoma (OSCC), finding that higher JMJD5 levels correlate with larger tumors and worse survival rates.
  • It explores the anticancer effects of silibinin, a drug known for its hepatoprotective properties, which shows promise in inhibiting tumor growth and downregulating JMJD5 in both lab studies and mouse models with patient-derived tumors.
  • The research highlights that JMJD5 may serve as a valuable prognostic marker for OSCC and suggests that targeting JMJD5 with silibinin, possibly via the MTA1 pathway, could be a novel approach in
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A cDNA encoding a putative glutathione reductase (GR) was cloned from sweet potato (Ib). The deduced protein showed high level of sequence homology with GRs from other plants (79-38%). A three-dimensional (3-D) homology structure was created.

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