KDM4C works in concert with GATA1 to regulate heme metabolism in head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer worldwide, presents significant public health challenges due to its genetic instability and late-stage diagnosis. Despite advancements in treatment, the median overall survival remains below one year, emphasizing the need for improved detection, prognosis, and therapeutic strategies. This study investigates the role of KDM4C and its interaction with GATA1 in regulating heme metabolism and tumor progression in HNSCC.

Disrupting neuron-tumor networking connections.

Neurons are key to brain tumor pathogenesis. Though direct synaptic connections between neurons and glioblastoma cells had been revealed, the nature of such connections remained enigmatic. In a recent issue of Cell, Tetzlaff et al.