Mitochondrial dysfunction-mediated hepatocyte senescence is involved in cholestatic liver injury.

Cholestatic liver injury is caused by cholestasis, which is accompanied by hepatic cell dysfunction. Cellular senescence refers to a permanent arrest of cell division and a decline in metabolic activity, without a clear role in the process of cholestatic liver injury. Here, in the liver tissue of patients with cholestatic liver diseases, we found an increased proportion of hepatic cells with senescence marker P21 expression in Fibrosis stage 4 (F4) patients when compared with F1/2 patients.

1,25(OH)D ameliorates DSS-induced intestinal ferroptosis through the SIRT3-SOD2-mtROS pathway.

Ferroptosis has been shown to play a significant role in the pathogenesis of ulcerative colitis (UC). This study investigated the effects of 1,25(OH)D supplementation on ferroptosis in dextran sulfate sodium (DSS)-evoked colitis. Intestinal VDR was reduced in UC patients.

MitoQ protects against carbon tetrachloride-induced hepatocyte ferroptosis and acute liver injury by suppressing mtROS-mediated ACSL4 upregulation.

Ferroptosis has been shown to be involved in carbon tetrachloride (CCl)-induced acute liver injury (ALI). The mitochondrion-targeted antioxidant MitoQ can eliminate the production of mitochondrial reactive oxygen species (mtROS). This study investigated the role of MitoQ in CCl-induced hepatocytic ferroptosis and ALI.

1,25(OH)D alleviates oxidative stress and inflammation through up-regulating HMGCS2 in DSS-induced colitis.

Background: Previous study found that supplements with active vitamin D3 alleviated experimental colitis. The objective of this study was to investigate the possible role of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), a ketone synthase, on vitamin D3 protecting against experimental colitis.

Methods: HMGCS2 and vitamin D receptor (VDR) were measured in UC patients.

Risk factors of recurrent choledocholithiasis following therapeutic endoscopic retrograde cholangiopancreatography.

Background: The risk factors for the recurrent choledocholithiasis after endoscopic retrograde cholangiopancreatography (ERCP) have not been well studied. The aim of this study was to explore the risk factors of recurrent choledocholithiasis.

Methods: We carried out a retrospective analysis of data collected between January 1, 2010 and January 1, 2020.

[A comparative study of phenoloxidase activity between and ].

Objective: To study the differences of the phenoloxidase (PO) relative activity among ribbed shelled , smooth shelled and .

Methods: The crude PO fluid was extracted from the soft tissue of and by homogenation and centrifugation. The PO activity was detected with catechol as the substrate in the reaction systems.