Highly oxidized rearranged derivatives of quinochalcone C-glycosides from Carthamus tinctorius.

Safflopentsides A-C (1-3), three highly oxidized rearranged derivatives of quinochalcone C-glycosides, were isolated from the safflower yellow pigments. Their structures were determined based on a detailed spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR), and the absolute configurations were confirmed by the comparison of experimental ECD spectra with calculated ECD spectra. Compounds 1-3 have an unprecedented cyclopentenone or cyclobutenolide ring A containing C-glucosyl group, respectively.

Two new quinochalcone glycosides from the safflower yellow pigments.

Two new quinochalcone glycosides, hydroxysafflor yellow A-4'---D-glucopyranoside () and 3'-hydroxyhydroxysafflor yellow A (), were isolated from the safflower yellow pigments of . The structures of new compounds were elucidated by a detailed spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR, ECD). The assay indicated that compound could improve the survived rate of primary mouse cortical neurons on glutamate-induced neurons damage model at a concentration of 10 μM.