Discovery of flavonoids with quorum sensing inhibitory activity from Hymenocallis littoralis.

Hymenocallis littoralis (Jacq.) Salisb. was a traditional folk medicinal herb used externally in China.

Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations.

Unlabelled: Tuberculosis, caused by , remains one of the most lethal infectious diseases both historically and in the post-coronavirus disease 2019 era. CdnP (Rv2837c) functions as a bifunctional oligoribonuclease and 3'(2')-phosphoadenosine 5'-phosphate-phosphatase that impedes host immune responses by recognizing bacterial cyclic dinucleotides such as c-di-AMP, which serve as pathogen-associated molecular patterns. Despite its significance, strategies targeting CdnP remain limited.

Discovery of quorum sensing inhibitors against Pseudomonas aeruginosa from Aspergillus sp. NB12.

Twelve secondary metabolites, including two undescribed steroids, aspesterols A (1) and B (2) and three new triterpenoids, aspertrinoids A-C (5-7), were isolated from the endophytic fungus Aspergillus sp. NB12 obtained from Hypericum patulum. Structurally, aspertrinoids A-C (5-7) were 30-norlanostane triterpenoids with a C9 side-chain moiety and a hemiacetal moiety formed between C-3 and C-19.