Clinical Features of Chinese Patients with Thyroid Eye Disease: A Multicenter Retrospective Study.

Thyroid eye disease (TED) is a debilitating autoimmune disorder linked to thyroid dysfunction. There is limited knowledge of TED in Asian populations. This multicenter study characterizes the clinical features and treatment response of TED in a large Chinese cohort.

Diagnostic accuracy of B scan ultrasound for posterior segment ocular disorders: a meta-analysis.

Purpose: B-scan ultrasound is widely utilized for diagnosing posterior segment ocular disorders due to its non-invasive nature and ability to provide real-time imaging. This meta-analysis evaluates the diagnostic accuracy of B-scan ultrasound in detecting various posterior segment ocular disorders.

Methods: A comprehensive search was conducted across multiple databases including Medline, EMBASE, Cochrane Library, and SCOPUS, from their inception until May 2024.

Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis.

Background: Mounting evidence has shown that circular RNAs (circRNAs) have vital roles in human cancers, including retinoblastoma (RB). The purpose of this study was to investigate the exact roles and underlying mechanism of circRNA ER membrane protein complex subunit 9 (circ-FAM158A) in RB.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to determine the expression levels of circ-FAM158A, miR-138-5p and solute carrier family 7 member 5 (SLC7A5).

Comparison of machine learning tools for the prediction of AMD based on genetic, age, and diabetes-related variables in the Chinese population.

Introduction: Age-related macular degeneration (AMD) is the main cause of visual impairment and the most important cause of blindness in older people. However, there is currently no effective treatment for this disease, so it is necessary to establish a risk model to predict AMD development.

Methods: This study included a total of 202 subjects, comprising 82 AMD patients and 120 control subjects.

Rationally Designing Metal-Organic Frameworks Based on [Ln] Magnetic Building Blocks Utilizing 2-Hydroxyisophthalate and Fine-Tuning the Magnetic Properties of Dy Analogues by Terminal Coordinated Solvents.

By utilizing the 2-hydroxyisophthalic acid (HipO) ligand, 2D metal-organic frameworks (MOFs) featuring rare O-bridged [Ln]-magnetic building blocks (MBBs), [Ln(ipO)(DMF)(HO)] [Ln = Gd (), Dy (); DMF = ,-dimethylformamide], were rationally designed and synthesized. When the reaction solvents that behave as terminal ligands were changed, the coordination geometries of Ln ions and the arrangement fashion of [Ln]-MBBs for these MOFs were modified accordingly. Another type of 2D MOF of [Ln(ipO)(HO)]·2HO [Ln = Gd (), Dy ()] was thus obtained.

Kaempferol attenuates retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via JNK and NF-κB pathways in acute glaucoma.

Aims Or Purpose: Glaucoma is the leading cause of vision loss and blindness in the world. Elucidating the pathogenesis of glaucoma and developing effective treatment should be the priority. Inflammation and oxidative stress play essential roles in glaucoma pathogeneisis.

Curcumin Protects Trabecular Meshwork Cells From Oxidative Stress.

Purpose: Glaucoma is closely linked with oxidative stress and inflammation, and difficult to treat. Its occurrence frequently is contributed by the failure of the trabecular meshwork (TM). Curcumin is known as an antioxidative and anti-inflammatory substance, possessing the potential to treat glaucoma.