Identification of mutation of MYOC (c.1099G>A), a pedigree pathogenic gene of juvenile open angle glaucoma (JOAG): A case report.

Rationale: The MYOC gene is associated with juvenile open-angle glaucoma (JOAG). This study aims to provide genetic counseling for a Chinese JOAG family by detecting MYOC mutations to identify high-risk individuals for early JOAG intervention. It also supplements the clinical characteristics of glaucoma patients with MYOC gene mutations.

Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2.

Gastric cancer is a most common malignancy and the third leading cause of cancer mortality worldwide. So it is important to identify the prognostic markers and effective therapeutic targets against gastric cancer. miRNA plays an important role in tumor cell cycle, differentiation, apoptosis, invasion and metastasis.

[Topological models of retention index of thin-layer chromatogram for chiral organic acids].

On the basis of Kier's molecular connectivity indices and conjugated matrix, novel molecular connectivity indices ((m) G(t)(v)) were defined and calculated for 18 chiral hydroxyl acids and amino acids. The chiral connectivity indices ((m)C(t)(v)) were introduced by extending (m)G(t)(v): (m)C(t)(v) = (m)G(t)(v) x w(j), where w(j) is the chiral index. The quantitative structure-retention index relationship (QSRR) between the retention index (R(M)) of thin-layer chromatogram for the chiral organic acids and (m)C(t)(v) was studied by multivariate statistical regression.

2-(2-Chloro-phen-yl)-2,3-dihydro-quinazolin-4(1H)-one.

The title compound, C(14)H(11)ClN(2)O, was synthesized by the reaction of 2-chloro-benzaldehyde and 2-amino-benzamide in an ionic liquid. The pyrimidine ring adopts a skew-boat conformation and the two benzene rings make a dihedral angle of 87.1 (1)°.

Topological research on diamagnetic susceptibilities of organic compounds.

A novel molecular connectivity index, (m)chi('), based on the adjacency matrix of molecular graphs and novel atomic valence connectivities, delta(i)(') for predicting the molar diamagnetic susceptibilities of organic compounds is proposed. The delta(i)(') is defined as: delta(i)(') = delta(i)(nu) x Ei=12:625, where delta(i)(nu) and E(i) are the atomic valence connectivity and the valence orbital energy of atom i, respectively. A good QSPR model for molar diamagnetic susceptibilities can be constructed from (0)chi('), (1)chi('), (2)chi(') and (4)chi(p)(') using multivariate linear regression (MLR).

[Detecting the haplotype of three Y-STR loci by fluorescent multiplex amplification].

Objective: To establish a fluorescent multiplex PCR system for typing Y-STR loci Y-GATA-A7.1, DYS456 and DYS443, and investigate their haplotype frequencies in Chinese Han population.

Methods: 203 unrelated males of Han population living in Zhengzhou were typed by fluorescent multiplex amplification system and ABI 3100 genetic analyzer.

[Correlation analysis of structures and gas chromatographic retention indices of aliphatic alcohols].

A characteristic value of atom i is defined as A(i) = (delta(i)v + sigma n(ij)v)/(1 + sigma n(ij)). Based on the adjacency matrix, an average valence connectivity index is set up by A(i) as (m)L = sigma (A(i), x A(j) x A(k)..