Bioactivity-guided characterisation of iberin from (Bigelow) Hook. inducing apoptosis in human melanoma cells.

Despite important advances in cancer therapy, there remains a significant demand for the development of more effective, cancer-selective, and safer chemotherapy drugs. Plants have traditionally been a rich source of natural products that serve as remarkable anticancer agents, and they continue to play a crucial role in drug discovery. (Bigelow) Hook.

Descriptions of three new species of Philodinida (Rotifera, Bdelloidea) from Korea.

A taxonomic study on bdelloid rotifers collected from terrestrial habitats such as mosses and leaf litter at two different locations in Korea resulted in three new species, Habrotrocha changhoi n. sp., H.

The Correlations between the Intensity of Histopathological Ubiquitin-Specific Protease 11 Staining and Progression of Prostate Cancer.

Background: Ubiquitin-specific protease 11 (USP11), one of the principal phosphatase and tensin homolog (PTEN) deubiquitinases, can reserve PTEN polyubiquitination to maintain PTEN protein integrity and inhibit PI3K/AKT pathway activation. The aim of the current study was to investigate the associations between immunohistochemical USP11 staining intensities and prognostic indicators in individuals with prostate cancer.

Methods: Tissue microarrays (TMAs) were performed for human prostate cancer and normal tissue (control) samples.

Adenovirus VA RNAs impair maturation of primary microRNA.

Background: Adenovirus expresses two non-coding virus-associated (VA) RNAs: VA I RNA and VA II RNA. Adenovirus-expressed VA RNAs interfere with the microRNA (miRNA) pathway by competing with precursor miRNAs. The processing pattern of primary miRNA (pri-miRNA) and factors to affect its processing are not exactly known when using adenovirus for the delivery of pri-miRNA.

Nationwide assessment of atmospheric organochlorine pesticides over a decade during 2008-2017 in South Korea.

Long-term nationwide atmospheric monitoring of organochlorine pesticides (OCPs) was performed in South Korea during 2008-2017. Their occurrences, seasonal and temporal variability, sources, and effect of ambient temperature were investigated. The OCPs are pronounced with a mean concentration of total OCPs ranging from 5.

The correlation between the expression of ubiquitin-conjugating enzyme 2C and prostate cancer prognosis.

Purpose: Ubiquitin-conjugating enzyme E2 C (UBE2C) is known to show a causal relationship with cancer development and advancement. The role of UBE2C is to control the mitotic spindle checkpoint. Excess UBE2C has been identified in patients with advanced prostate cancer.

The Effect of Testosterone Replacement on Sexual Function in the Elderly: A Systematic Review and Meta-Analysis.

Purpose: Healthy aging is an important concern in an aging society. Although the causal relationship between hypogonadism and erectile dysfunction in elderly men remains unclear, many physicians have achieved positive results after implementing exogenous testosterone supplementation therapy in patients with normal or slightly low blood testosterone. The purpose of this study was to conduct a systematic review and meta-analysis on whether testosterone replacement therapy (TRT) could improve sexual function in the elderly, as reported recently.

Association between Osteoporosis and Meniere's Disease: Two Longitudinal Follow-Up Cohort Studies.

A high rate of Meniere's disease (MD) in patients with osteoporosis has been suggested. This research intended to estimate the bidirectional association of MD with osteoporosis. The ≥40-year-old population in the Korean National Health Insurance Service-Health Screening Cohort 2002-2019 was examined.

Does the COVID-19 Screening Test Affect the Postoperative Prognosis of Patients Who Undergo Emergency Surgery for Cerebral Hemorrhage?

Objective: The coronavirus disease 2019 (COVID-19) pandemic has affected all medical fields, including neurosurgery. Particularly, performing preoperative screening tests has become mandatory, potentially extending the time from admission to the emergency room and operating room, thus possibly affecting patients' prognosis. This study aimed to determine the influence of COVID-19 screening time on patients' postoperative prognosis.

Descriptions of Philodinavus koreanus n. sp. and two new species of Philodina (Rotifera, Bdelloidea) from Korea.

The bdelloid rotifers collected from terrestrial habitats such as leaf litter, mosses and tree barks were studied and three new species were identified: Philodina haejooni n. sp., P.

Organochlorine pesticides in the urban, suburban, agricultural, and industrial soil in South Korea after three decades of ban: Spatial distribution, sources, time trend, and implicated risks.

Organochlorine pesticides in soil samples across urban, suburban, agricultural, and industrial sites were analyzed every year between 2013 and 2016 in South Korea. The study aims to understand the residual status, diminution of occurrence from the South Korean environment, and its risk to humans after three decades of the ban. A general decreasing trend of OCPs has been observed over the years.

Is the Number of Missing Teeth Associated With Mortality? A Longitudinal Study Using a National Health Screening Cohort.

This study aimed to estimate the risk of mortality related to the number of missing teeth in a South Korean population. The ≥ 40-year-old population of the Korean National Health Insurance Service-Health Screening Cohort 2002-2003 was analyzed. Participants were selected from a total of 220,189 participants and included in groups of 0 teeth lost, 1-2 teeth lost, and ≥ 3 teeth lost.

Association Between Meniere Disease and Migraine.

Importance: A connection between Meniere disease (MD) and migraine has been proposed, but the temporal association remains unknown.

Objective: To examine the bidirectional association of MD with migraine.

Design, Setting, And Participants: This case-control study included participants 40 years or older from the Korean National Health Insurance Service Health Screening Cohort from 2002 to 2015.

Association of sudden sensorineural hearing loss with asthma: a longitudinal follow-up study using a national sample cohort.

Objective: To investigate the risk of sudden sensorineural hearing loss (SSNHL) in asthma patients.

Design: A longitudinal follow-up study using a retrospective cohort SETTING: The 2002-2013 Korean National Health Insurance Service-Health Screening Cohort PARTICIPANTS AND INTERVENTIONS: The ≥40 years old Korean population were enrolled. The asthma patients were 1:1 matched with the control group for age, sex, income and region of residence.

Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats.

Telmisartan (TM) has been proposed to relieve inflammatory responses by modulating peroxisome proliferator activator receptor-γ (PPARγ) signaling. This study aimed to investigate the protective effects of TM on kanamycin(KM)-induced ototoxicity in rats. Forty-eight, 8-week-old female Sprague Dawley rats were divided into four groups: (1) control group, (2) TM group, (3) KM group, and (4) TM + KM group.

Association Between Asthma and Meniere's Disease: A Nested Case-Control Study.

Objectives/hypothesis: This study aimed to investigate the association between Meniere's disease and prior history of asthma.

Study Design: A nested case-control study.

Methods: Among the patients aged ≥40 years from the Korean National Health Insurance Service-Health Screening Cohort 2002-2015, 7,734 diagnosed with Meniere's disease between 2004 and 2015 were enrolled in this study.

MicroRNA Dysregulation in the Hippocampus of Rats with Noise-Induced Hearing Loss.

Although hippocampal changes due to noise-induced hearing loss have been suggested, little is known about the miRNA levels due to these hippocampal changes. Three-week-old Sprague-Dawley rats were divided into noise and control groups ( = 20 per group). The noise group rats were exposed to white Gaussian noise (115 dB SPL, 4 hours per day) for three days.

The Positive Correlations between the Expression of Histopathological Ubiquitin-Conjugating Enzyme 2O Staining and Prostate Cancer Advancement.

Background: The mTOR signaling pathway is inactivated by AMPK's tumor-suppressing function. It is recognized that ubiquitin conjugating enzyme 2O (UBE2O), which directly targets AMPK for ubiquitination and degradation, is intensified in human cancers.

Methods: This study investigated the clinical data about prostate cancer.

Effects of short- and long-term exposure to air pollution and meteorological factors on Meniere's disease.

The association between air pollutants and Meniere's disease has not been explored. The present study investigated the relationship between meteorological factors and air pollutants on Meniere's disease. Participants, aged ≥ 40 years, of the Korean National Health Insurance Service-Health Screening Cohort were included in this study.

Association between statin medication and hearing impairment in a national health screening cohort.

This study aimed to investigate the association of previous stain use with hearing impairment in an adult population. Data from the ≥ 40-year-old population in the Korean National Health Insurance Service Health Screening Cohort were used. The hearing impairment group was classified based on the national registry of hearing-impaired persons.

Efficacy of testosterone replacement therapy for treating metabolic disturbances in late-onset hypogonadism: a systematic review and meta-analysis.

Purpose: Late onset hypogonadism (LOH) is an age-dependent reduction of testosterone associated with alterations of metabolic profile, including glucose control, insulin sensitivity, and lipid profile. The purpose of this study was to investigate the efficacy of testosterone replacement therapy (TRT) for treating metabolic disturbances through a meta-analysis of randomized clinical trials (RCTs).

Methods: A systematic review of literature published from 1964 to November, 2019 was performed using the PubMed/Medline, Embase, and Cochrane databases.