Publications by authors named "Cecile Chevallier"

In France, cannabis is the most widely used illicit psychoactive substance. Recently, a new market for cannabidiol (CBD) products has emerged called "cannabis light" or "cannabis well-being". In parallel, the experimentation of medical cannabis began on March 26, 2021, for specific indications.

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Introduction: Ammonia solution (ammonium hydroxide) is used to convert cocaine hydrochloride to freebase cocaine. Due to its causticity, unintentional exposure to ammonia in a substance use context can result in injury. The objective of this study was to describe the characteristics of unintentional oral and buccal ammonia solution exposure in a substance use context.

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Article Synopsis
  • Ketamine is increasingly being used non-medically, especially among individuals with substance use disorders, with a notable rise in users from 2012 to 2021 according to data from the OPPIDUM program.
  • Analysis of the French National Pharmacovigilance Database between 2020 and 2022 revealed that a significant proportion of ketamine cases involved complications like ketamine use disorder and symptoms related to urinary and liver issues.
  • The findings highlight a concerning trend of growing ketamine use among substance users and associated health complications, although the overall non-medical use rates in the general population remain unclear.
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  • GHB is produced naturally from GABA or can be obtained from substances like 1,4-butanediol and GBL, which are quickly converted to GHB in the body.
  • When ingested, GHB has a rapid absorption rate and its effects vary based on dosage, often leading to neurological disorders and potential withdrawal symptoms with long-term use.
  • While GHB is regulated internationally due to its association with abuse and drug-facilitated crimes, substances like GBL and 1,4-BD are not as strictly controlled, necessitating careful monitoring to prevent misuse and related health risks.
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It is important to assess drug abuse liability in 'real life' using different surveillance systems. OPPIDUM ('Observation of illegal drugs and misuse of psychotropic medications') surveillance system anonymously collects information on drug abuse and dependence observed in patients recruited in specialized care centers dedicated to drug dependence. The aim of this article is to demonstrate the utility of OPPIDUM system using 2015 data.

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