Publications by authors named "Carolyn Ee"

Objective: Premature ovarian insufficiency (POI) is associated with reduced quality of life and increased health risks. While hormone therapy (HT) is standard treatment, some women seek other options to treat its sequelae. This review explores the role of complementary therapies for POI.

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Background: Women with polycystic ovary syndrome (PCOS) use traditional medicines such as Ayurveda (traditional Indian medicine) to manage their symptoms. Dietary and lifestyle advice is one of the major components of Ayurveda treatment, however, it remains unexplored. This study aimed to understand the perspectives of Ayurveda clinicians regarding PCOS and excess weight, and its management through diet and lifestyle.

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Background: Type 2 diabetes mellitus (T2DM) can lead to macro- and microvascular complications. Mindfulness-based interventions (MBIs) may improve metabolic and psychological health in individuals with T2DM. We aimed to assess the efficacy of MBIs for management of T2DM.

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Background And Purpose: Heart failure (HF) is associated with multi-organ dysfunction and significant morbidity and mortality. Despite advances in treatment, prognosis remains poor, highlighting the need to explore adjunctive therapies such as integrative medicine. This umbrella review synthesises top-tier evidence from systematic reviews and meta-analyses of randomised controlled trials (RCTs) assessing the safety and effectiveness of integrative medicine in patients with HF, in order to inform clinical decision-making.

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Introduction: Over one million Australians live with a cancer diagnosis, with nearly a quarter speaking a language other than English. Cancer survivors from culturally and linguistically diverse (CALD) backgrounds often face significant unmet needs during survivorship, including navigating the healthcare system and accessing culturally appropriate support. For example, Chinese- and Vietnamese-speaking survivors report physical and psychosocial impacts, compounded by limited availability and access to tailored information on symptom management and recurrence prevention.

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Improvements in the quality of penile cancer management are difficult due to the rarity of the condition and a limited evidence base for treatment decisions. Penile cancer and some of its highly morbid treatments can cause profound psychosexual and physical effects that negatively impact quality of life. Multidisciplinary interventions are required to equip patients with the support necessary to manage their emotional, physical, work, and lifestyle challenges to optimize health, well-being, and recovery.

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Background: During adolescence, accurate diagnostic criteria and/or identification of adolescents "at risk" of polycystic ovary syndrome (PCOS) are critical to establish appropriate screening, treatment, and lifelong health plans. The 2023 International Evidence-Based Guideline for PCOS aimed to provide the most up-to-date evidence-based recommendations to improve health outcomes for individuals with PCOS, emphasizing accurate and timely diagnosis of PCOS from adolescence.

Methods: The best practice methods following the Appraisal of Guidelines for Research and Evaluation (AGREE-II) criteria were applied.

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Background: Current models of post-treatment cancer care rely heavily on hospital-based, medical specialists and do not sufficiently leverage primary care. Many breast cancer survivors face ongoing unmet needs that may benefit from a multidisciplinary, shared-care approach. We aimed to evaluate the feasibility and preliminary effectiveness of implementing nurse-enabled, shared-follow-up care between the acute and primary care setting for early-stage breast cancer.

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Objective: Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI. This review aims to identify the role of lifestyle, including diet and physical activity, in managing symptoms, improving quality of life (QoL) and preventing chronic disease in women with POI.

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Background And Objectives: Nutrient supplements are commonly used to improve fertility outcomes by women with infertility trying to conceive spontaneously or utilising medically assisted reproduction (MAR). However, despite their widespread use and perceived safety, there is a lack of clear guidance on the efficacy and safety of these supplements for female infertility. The aim of this umbrella review was to identify the best available and most recent evidence on the efficacy and safety of nutrient supplements for female infertility to provide evidence-based guidance for clinicians and reproductive couples.

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Introduction: Australian breast cancer survivors are at increased risk of cardiovascular disease and mortality, partly due to behavioural risk factors, including unhealthy diet and physical inactivity. Guidelines recommend health promotion delivered by general practitioners (GPs), but resources (ie, time and funding) are limited. Text message interventions sent from general practice to survivors may offer a low-resource solution but have not been evaluated.

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Study Question: How should premature/primary ovarian insufficiency (POI) be diagnosed and managed based on the best available evidence from published literature?

Summary Answer: The current guideline provides 145 recommendations on symptoms, diagnosis, causation, sequelae, and treatment of POI.

What Is Known Already: Premature ovarian insufficiency (POI) presents a significant challenge to women's health, with far-reaching implications, both physically and emotionally. The potential implications include adverse effects on quality of life; fertility; and bone, cardiovascular, and cognitive health.

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Study Question: How should premature/primary ovarian insufficiency (POI) be diagnosed and managed, based on the best available evidence from published literature?

Summary Answer: The current guideline provides 145 recommendations on symptoms, diagnosis, causation, sequelae and treatment of POI.

What Is Known Already: Premature ovarian insufficiency (POI) presents a significant challenge to women's health, with far-reaching implications, both physically and emotionally. The potential implications include adverse effects on quality of life; fertility; and bone, cardiovascular and cognitive health.

View Article and Find Full Text PDF

Study Question: How should premature/primary ovarian insufficiency (POI) be diagnosed and managed, based on the best available evidence from published literature?

Summary Answer: The current guideline provides 145 recommendations on symptoms, diagnosis, causation, sequelae and treatment of POI.

What Is Known Already: POI presents a significant challenge to women's health, with far-reaching implications, both physically and emotionally. The potential implications include adverse effects on quality of life, on fertility and on bone, cardiovascular and cognitive health.

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Background: The number of people living with or beyond cancer are expected to rise. General practice-led cancer survivorship plans have been proposed as a way to address ongoing healthcare needs (including physical and psychosocial care) and care coordination, as well as the prevention and management of other chronic illnesses.

Objective: The aim of this paper is to discuss the role of general practice in the long-term care of cancer survivors and provide a summary of recommendations for comprehensive cancer survivorship care planning in general practice.

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Purpose: After breast cancer diagnosis and treatment, the majority of women will gain weight. The aim of this study was to describe the experiences of weight management among Australian women with breast cancer.

Methods: This is a secondary analysis of data from a qualitative study evaluating the feasibility of novel interventions for weight management after breast cancer.

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Article Synopsis
  • Many cancer survivors worry about their cancer coming back, but healthcare providers often don’t help them with this fear.
  • A group of Australian health experts worked together to create a plan for doctors to better understand and manage this fear in patients who had early-stage cancer.
  • They found that most items in their plan were agreed upon by the majority, suggesting that regular screenings and conversations about this fear should be part of cancer care.
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Article Synopsis
  • Many cancer survivors often have other health problems (multimorbidity), which makes their care more complicated and costly.
  • A study asked health professionals and cancer survivors about what is most important for their care and research, resulting in a list of principles and supports they agreed on.
  • The study found that focusing on survivorship, self-management, and peer support is essential for helping cancer survivors manage their health better.
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Article Synopsis
  • - Polycystic ovary syndrome (PCOS) is a common yet often undiagnosed hormonal disorder in women, linked to various symptoms and an increased risk of chronic diseases like type 2 diabetes and cardiovascular issues.
  • - Treatment options for PCOS include the combined oral contraceptive pill for irregular menstrual cycles, hirsutism, and acne, as well as metformin for weight loss and metabolic improvements in those with higher body mass index.
  • - Lifestyle modifications are crucial in managing PCOS, and the use of anti-obesity medications can be considered alongside these changes for better weight management.
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Fatigue, insomnia and sleep disturbances are common after cancer diagnosis, and have a negative impact on quality of life and function. This narrative review synthesised evidence on lifestyle and integrative oncology interventions for cancer-related fatigue, insomnia and sleep disturbances in cancer survivors. There is strong evidence in support of aerobic and strength exercise for the relief of cancer-related fatigue.

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Purpose: To identify the key attributes of breast cancer follow-up care models preferred by cancer survivors in Australia.

Methods: A discrete choice experiment (DCE) was conducted to elicit preferences for attributes of breast cancer follow-up care. Respondents were presented with two hypothetical scenarios, known as choice sets, and asked to select a preference.

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Research Question: Is conducting a randomized control trial (RCT) to assess the effectiveness of whole-system naturopathy in improving pregnancy rates among women with diminished ovarian reserve (DOR) feasible?

Design: A two-arm, parallel group, assessor-blinded feasibility RCT was conducted. Women with DOR, trying to conceive naturally or by ART, were randomly assigned to naturopathy plus usual care, or usual care alone for 16 weeks. Primary outcomes were feasibility (recruitment, adherence, retention rates), acceptability and safety.

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Objective: An umbrella review was conducted to provide a comprehensive evaluation of the evidence on lifestyle medicine and integrative therapies for inflammatory arthritis.

Methods: Five electronic databases were searched for umbrella reviews, meta-analyses, and systematic reviews of randomised controlled trials on acupuncture, diet, exercise, herbal medicine, nutrient supplements, and mind-body therapies for rheumatoid arthritis, spondyloarthritis, and gout published from January 2012 to December 2022. The primary outcomes were functional status and quality of life.

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