Transmembrane AMPA receptor regulatory protein TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice.

Background: Behavioral pathologies that characterize alcohol use disorder (AUD) are driven by the powerful reinforcing, or rewarding, properties of the drug. We have shown that glutamate AMPA receptor (AMPAR) activity is both necessary and sufficient for alcohol (ethanol) reinforcement. Transmembrane AMPAR regulatory protein (TARP) γ-8 is an essential auxiliary protein that regulates AMPAR expression and activity; however, the role of TARP ɣ-8 in AUD or other forms of addiction remains largely unexplored.

Teacher Personality Predicts Emotional Well-Being and Academic Achievement in Students with Specific Learning Disorders.

Students with specific learning disorders (SLDs) are at increased risk for emotional and academic difficulties. While teacher characteristics can influence student outcomes, few studies have examined the role of teacher personality in supporting students with SLDs. This study investigated whether teacher personality traits predicted student emotional well-being and academic achievement in a school-based intervention context.

TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice.

Background: Behavioral pathologies that characterize alcohol use disorder (AUD) are driven by the powerful reinforcing, or rewarding, properties of the drug. We have shown that glutamate AMPA receptor (AMPAR) activity is both necessary and sufficient for alcohol (ethanol) reinforcement. Transmembrane AMPAR regulatory protein (TARP) γ-8 is an essential auxiliary protein that regulates AMPAR expression and activity; however, the role of TARP ɣ-8 in AUD or other forms of addiction remains largely unexplored.

Examination of Driving Performance Across Autistic Drivers: A Meta-analysis.

Objective: It is becoming evident that the unique challenges faced by autistic drivers are contingent on the driving context and specific skills required. This meta-analysis examined the driving performance of both autistic and nonautistic drivers, aiming to clarify the reasons behind inconsistencies in published findings and identify the relative strengths and challenges faced by autistic drivers.

Method: This study was performed within a theoretical model of driving skills to break down the complex process of driving and identify specific strengths and challenges displayed by autistic drivers.

Is virtue its own reward? Moral identity, empathy, and volunteering during adolescence as predictors of subsequent epigenetic aging.

Higher levels of moral identity, empathy, and volunteering (virtues) are associated with increased self-esteem and psychological well-being, which, in turn, are predictive of fewer health problems. Epigenetic aging, a marker of health, reflects the rate at which individuals age biologically relative to their chronological age. Epigenetic aging is shaped by behavioral factors and environmental stressors, but the effects of moral identity, empathy, and volunteering on epigenetic aging are underexplored.

Measures of emotional well-being for individuals with intellectual disabilities: A scoping review of reviews.

Objective: This scoping review of reviews examines how one facet of quality of life, emotional well-being (EWB), has been assessed for individuals with intellectual disabilities (ID), including the characteristics of measures that have been designed, adapted, or administered to individuals in this population.

Methods: Following established practices for scoping reviews, we searched the ERIC, APA Psych Info, and Academic Search Premier databases in November 2022 for review articles that included measures of EWB that had been designed, adapted, or administered to individuals with ID. Following PRISMA guidelines, we conducted independent double coding at the title and abstract and full text review stages.

Online peer mentoring for youth with learning differences.

Youth with learning differences (e.g., specific learning disorder and attention deficit hyperactivity disorder) encounter exacerbated psychological and behavioral challenges compared to typically developing peers.

The Driving Profile of Autistic Drivers and Their Driving Experiences: A Systematic Review.

A developmental milestone that both contributes to and facilitates a successful transition into adulthood is the ability to drive. Yet only one in three autistic adolescents successfully obtain a driver's license by age 21 compared to over three-fourths of non-autistic adolescents. Of those who receive their license, there is inconsistency in driving attitudes, experiences and skills.

Stress, resilience, and emotional well-being in children and adolescents with specific learning disabilities.

This article reviews the prevalence of stress and explores resilience factors in children and adolescents with specific learning disabilities (SLDs). We show that the increased stress and emotional challenges faced by this group are likely due to societal pressures and stigma. Recent findings on neuroendocrine changes in this population are discussed, suggesting a predisposition to psychiatric disorders.

Moral identity in relation to emotional well-being: a meta-analysis.

Introduction: This meta-analytic review surveyed previous empirical studies that examined links between moral identity and indicators of emotional well-being. Additionally, this meta-analysis examined cultural origin as a moderator, testing if links between moral identity and emotional well-being differ in collectivistic vs. individualistic countries.

Perinatal influences on academic achievement and the developing brain: a scoping systematic review.

Introduction And Methods: In this PRISMA-compliant systematic review, we identify and synthesize the findings of research in which neuroimaging and assessments of achievement have been used to examine the relationships among aspects of developmental programming, neurodevelopment, and achievement in reading and mathematics.

Results: Forty-seven studies met inclusion criteria. The majority examined the impact of prematurity ( = 32) and prenatal alcohol exposure ( = 13).

Brain imaging studies of emotional well-being: a scoping review.

Unlabelled: This scoping review provides an overview of previous empirical studies that used brain imaging techniques to investigate the neural correlates of emotional well-being (EWB). We compiled evidence on this topic into one accessible and usable document as a foundation for future research into the relationship between EWB and the brain. PRISMA 2020 guidelines were followed.

Longitudinal Predictors of Word Reading for Children with Williams Syndrome.

We examined the cognitive, language, and instructional predictors of early word-reading ability in a sample of children with Williams syndrome longitudinally. At Time 1, sixty-nine 6-7-year-olds (mean age = 6.53 years) completed standardized measures of phonological awareness, visual-spatial perception, vocabulary, and overall intellectual ability.

The impact of computer-assisted technology on literacy acquisition during COVID-19-related school closures: Group-level effects and predictors of individual-level outcomes.

Introduction: The COVID-19 pandemic led to school closure and loss of in-person instruction during the 2019-2020 academic year across the United States, which had a profound impact on the reading development of beginning readers. In this study we tested if a research-informed educational technology (EdTech) program-GraphoLearn-could help alleviate the COVID-19 slide. We also sought to understand the profiles of children who benefitted most from this EdTech program.

Pathological Reporting of Radical Prostatectomy Specimens Following ICCR Recommendation: Impact of Electronic Reporting Tool Implementation on Quality and Interdisciplinary Communication in a Large University Hospital.

Prostate cancer represents one of the most common malignant tumors in male patients in Germany. The pathological reporting of radical prostatectomy specimens following a structured process constitutes an excellent prototype for the introduction of software-based standardized structured reporting in pathology. This can lead to reports of higher quality and could create a fundamental improvement for future AI applications.

[Standardized diagnosis of pancreatic head carcinoma].

Most pancreatic ductal adenocarcinomas are localized in the pancreatic head. Due to the complex anatomic relationships with the surrounding organs and vascular structures in the retroperitoneal space and to the presence of numerous transection margins and dissection planes, pancreatic head resections belong to the most complex specimens concerning grossing and sampling for histopathologic analysis.Here we discuss current guidelines for standardized grossing and reporting of pancreatic cancer, with special reference to the assessment of the resection margin status.

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse.

Acute otitis media, inflammation of the middle ear, is the most common bacterial infection in children and, as a consequence, is the most common reason for antimicrobial prescription to this age group. There is currently no effective vaccine for the principal pathogen involved, non-typeable Haemophilus influenzae (NTHi). The most frequently used and widely accepted experimental animal model of middle ear infection is in chinchillas, but mice and gerbils have also been used.

Effect of recombinant human keratinocyte growth factor (Δ23rHuKGF, Palifermin) on inflammatory and immune changes in mouse tongue during fractionated irradiation.

Purpose: A significant reduction in the incidence of radiation-induced oral mucositis by Palifermin has been demonstrated. The underlying mechanisms, however, remain unclear. The aim of the present study was to assess the effect of Palifermin on inflammatory and immune processes during fractionated irradiation in mouse tongue.