Trends in Industry Payments to Oral and Maxillofacial Surgeons: Analysis of the Open Payments Database 2017 to 2024.

Background: Industry payments to health-care providers are publicly reported under the Physician Sunshine Act. However, little is known about the scope and distribution of these financial relationships in oral and maxillofacial surgery.

Purpose: The purpose of this study was to evaluate trends in industry payments to oral and maxillofacial surgeons (OMSs) over time.

Does Elective Tracheostomy Reduce the Incidence of Airway Complications and Adverse Outcomes in Free Flap Reconstruction of Oral Cavity Malignancies?

Elective tracheostomy is commonly performed to secure the airway following major oncologic and reconstructive head and neck procedures, though it carries risks of additional morbidity and may not be necessary in all cases. The purpose of this study was to evaluate the association between elective tracheostomy and postoperative airway complications. This was a retrospective cohort study of all patients undergoing resection and free flap reconstruction of an oral cavity cancer from 2012 to 2022 in the American College of Surgeons National Surgical Quality Improvement Program databases.

SBRT for bridging and downstaging HCC before transplant.

Background & Aims: Stereotactic body radiotherapy (SBRT) has emerged as a bridging/downstaging therapy for patients with hepatocellular carcinoma (HCC) awaiting liver transplantation (LT). This study evaluates the safety and outcomes of the use of SBRT in such patients.

Methods: A retrospective review was conducted from 2004 to 2019 on 88 adult patients with HCC receiving SBRT as bridging/downstaging therapy.

How Does Thrombocytopenia Affect Outcomes in Head and Neck Cancer Surgery With Free Flap Reconstruction?

Background: Thrombocytopenia is associated with a variety of medical comorbidities seen in patients with head and neck cancer. However, it remains unclear if and how thrombocytopenia affects surgical outcomes.

Purpose: The purpose of this study was to measure the association between thrombocytopenia and 30-day adverse outcomes in patients undergoing head and neck cancer surgery with free flap reconstruction.

Caregiver Perspectives on the Continuum of Social Needs Care: A Qualitative Study in Pediatric Primary Care.

Objective: To explore caregivers' experiences with and preferences for 1) HRSN screening, 2) electronic medical record (EMR) documentation of HRSN, and 3) community resource referral mechanisms including the use of a patient-facing, web-based community resource platform.

Methods: Focus groups and semi-structured interviews were conducted with caregivers of pediatric patients with the preferred language of English or Spanish receiving primary care in an academic practice in Baltimore, Maryland. Data collection occurred until thematic saturation was reached, and qualitative analysis followed an iterative thematic analysis approach.

Is Treatment at a Level 1 Trauma Center Associated With Better Outcomes in Adults With Isolated Midface Fractures?

Background: Treatment at a level 1 trauma center is associated with better outcomes for a multitude of traumatic injuries. Yet, the relationship between trauma center designation and treatment outcomes in the context of midface trauma remains poorly understood.

Purpose: The purpose of this study was to evaluate the association between trauma center designation and clinical outcomes in patients undergoing an operative intervention for isolated midface trauma.

Evaluating the Management of chronic Pelvic girdle Pain following pregnancy (EMaPP): a randomised controlled feasibility trial.

Background: Postpartum pelvic girdle pain (PGP), experienced by approximately 10% of women, is typically refractory to conservative management. Customised dynamic elastomeric fabric orthoses (DEFOs) are one novel option to address this. We assessed the feasibility and acceptability of a randomised controlled trial comparing a DEFO plus standardised advice/exercises (intervention) versus standardised advice/exercise alone (control).

Insurance payor is associated with transfer of emergency department pediatric patients with odontogenic infections.

Objective: The objective of this study was to evaluate the association between insurance payor and interfacility transfer in pediatric patients with odontogenic infections.

Study Design: This retrospective cohort study utilized the 2018 Nationwide Emergency Department Sample. Patients < 18 years old with odontogenic infections were included.

Intronic FGF14 GAA repeat expansions impact progression and survival in multiple system atrophy.

Partial phenotypic overlap has been suggested between multiple system atrophy and spinocerebellar ataxia 27B, the autosomal dominant ataxia caused by an intronic GAA•TTC repeat expansion in FGF14. In this study, we investigated the frequency of FGF14 GAA•TTC repeat expansion in clinically diagnosed and pathologically confirmed multiple system atrophy cases. We screened 657 multiple system atrophy cases (193 clinically diagnosed and 464 pathologically confirmed) and 1003 controls.

Is Treatment at a Level 1 Trauma Center Associated With Better Outcomes Among Patients With Isolated Mandible Fractures?

Background: The trauma literature suggests that treatment at a level 1 trauma center is associated with improved outcomes for a diversity of injuries. However, differences in outcomes with respect to trauma center designation are poorly studied in the facial trauma demographic.

Purpose: The purpose of this study was to measure the association between trauma center designation and clinical outcomes in patients undergoing management of isolated mandible fractures.

The Meaning of Autism Friendly in Hospital Settings: A Scoping Review of the Autism Community's Perspectives.

Hospitals are motivated to create more autism friendly environments to optimise access and experience for the community. However, there is a lack of clarity in what the term autism friendly in hospital settings means. We conducted a scoping review of four online databases and eleven national autism organisations to determine existing definitions for autism friendly within hospital settings.

Biodegradable polymeric microsphere formulations of full-length anti-VEGF antibody bevacizumab for sustained intraocular delivery.

Age-related macular degeneration (AMD) is one of the leading causes of central vision loss in the elderly population. Bevacizumab, a full-length humanized monoclonal anti-VEGF antibody, is commonly used off-label drug to treat AMD. However, the dosing regimen of bevacizumab and other anti-VEGF antibodies requires monthly intravitreal injections followed by regular intravitreal injections at 4-16-week intervals.

Trends in Opioid Prescriptions to Opioid-Naïve Patients by Oral and Maxillofacial Surgeons in Massachusetts 2012-2022.

Background: Many oral and maxillofacial surgery patients are young, healthy adults who are opioid-naïve. Over-prescribing opioids increases the risk of subsequent misuse and diversion.

Purpose: The purpose of this study was to measure and compare opioid prescriptions to opioid naïve and nonnaïve patients by oral and maxillofacial surgeons in Massachusetts from 2012 to 2022.

Outcomes of Stereotactic Body Radiotherapy Compared with Surgical Resection in Patients with Hepatocellular Carcinoma and Macrovascular Invasion: A Propensity Score-Matched Analysis.

Introduction: Patients with advanced hepatocellular carcinoma (HCC) and macrovascular invasion (MVI) are recommended to receive systemic therapy according to guidelines. Stereotactic body radiotherapy (SBRT) and surgery are increasingly used in this patient population. This study compares outcomes from these local treatments.

An alternative route for β-hydroxybutyrate metabolism supports fatty acid synthesis in cancer cells.

Cancer cells are exposed to diverse metabolites in the tumor microenvironment that are used to support the synthesis of nucleotides, amino acids, and lipids needed for rapid cell proliferation. Recent work has shown that ketone bodies such as β-hydroxybutyrate (β-OHB), which are elevated in circulation under fasting conditions or low glycemic diets, can serve as an alternative fuel that is metabolized in the mitochondria to provide acetyl-CoA for the tricarboxylic acid (TCA) cycle in some tumors. Here, we discover a non-canonical route for β-OHB metabolism, in which β-OHB can bypass the TCA cycle to generate cytosolic acetyl-CoA for fatty acid synthesis in cancer cells.

Factors affecting the risk of trismus following maxillary ablative surgery comparing free flap reconstruction to prosthetic obturation: a retrospective observational study.

The reconstruction of post-ablative maxillary defects is controversial. It is accepted that quality of life indicators are poorer for maxillary reconstruction compared with mandibular reconstruction. One factor highlighted is that of post-treatment trismus.

Is Insurance Payor Associated With Hospital Admission of Emergency Department Adult Patients With Odontogenic Infections?

Background: Patients who present to the emergency department (ED) with severe odontogenic infections are often hospitalized for surgical drainage and medical management. However, inpatient management of these patients can be financially burdensome. While medical indications for hospital admission are well established, it remains unclear if patient insurance status is associated with admission.

The influence of air masses on human mortality in the contiguous United States.

Temperature-related mortality is the leading cause of weather-related deaths in the United States. Herein, we explore the effect of air masses (AMs) - a relatively novel and holistic measure of environmental conditions - on human mortality across 61 cities in the United States. Geographic and seasonal differences in the effects of each AM on deseasonalized and detrended anomalous lagged mortality are examined using simple descriptive statistics, one-way analyses of variance, relative risks of excess mortality, and regression-based artificial neural network (ANN) models.

Elucidating the Mechanism of Efficient Eu(III) and Yb(III) Sensitisation from a Re(I) Tetrazolato Triangular Assembly.

The reaction of Re(CO)Br with deprotonated 1H-(5-(2,2':6',2''-terpyridine)pyrid-2-yl)tetrazole yields a triangular assembly formed by tricarbonyl Re(I) vertices. Photophysical measurements reveal blue-green emission with a maximum at 520 nm, 32 % quantum yield, and 2430 ns long-lived excited state decay lifetime in deaerated dichloromethane solution. Coordination of lanthanoid ions to the terpyridine units red-shifts the emission to 570 nm and also reveals efficient (90 %) and fast sensitisation of both Eu(III) and Yb(III) at room temperature, with a similar rate constant k on the order of 10 s.

Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking.

Ferroptosis is a form of cell death caused by lipid peroxidation that is emerging as a target for cancer therapy, highlighting the need to identify factors that govern ferroptosis susceptibility. Lipid peroxidation occurs primarily on phospholipids containing polyunsaturated fatty acids (PUFAs). Here, we show that even though extracellular lipid limitation reduces cellular PUFA levels, lipid-starved cancer cells are paradoxically more sensitive to ferroptosis.

Is Insurance Payer Associated With Hospital Admission of Emergency Department Patients With Mandible Fractures?

Background: There is a lack of consensus on the optimal triage pathway for emergency department (ED) patients with mandibular fractures. It remains unclear if patient insurance payers predict hospital admission given potentially competing logistical and health system incentives.

Purpose: To generate nationally representative estimates of the frequency of hospital admission and its association with primary insurance payers for ED patients with mandible fractures.