Publications by authors named "Caiyi Yan"
CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target.
Mol Ther Nucleic Acids
June 2025
Circular RNAs (circRNAs) are stable noncoding RNAs that play a crucial role in neurodegenerative diseases, and they have been implicated in the pathogenesis of postoperative cognitive dysfunction (POCD). However, their underlying molecular mechanisms in POCD remain poorly understood. This study identified hsa_circRNA_061570 as significantly upregulated in plasma after anesthesia/surgery using high-throughput circRNA microarray screening, correlating with cognitive decline.
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- Postoperative neurocognitive disorders (PNDs), which include postoperative cognitive dysfunction (POCD) and postoperative delirium (POD), are common after orthopedic surgery and can lead to negative outcomes.
- This study examined the effects of combining peripheral nerve block (PNB) with general anesthesia (GA) on the occurrence of POCD and POD compared to using GA alone.
- The findings revealed that combining PNB and GA significantly reduced the incidence of POCD but had no notable impact on POD; it also led to lower opioid use and reduced postoperative nausea and vomiting.
Let-7b-TLR7 Signaling Axis Contributes to the Anesthesia/Surgery-Induced Cognitive Impairment.
Mol Neurobiol
March 2024
Perioperative neurocognitive disorders (PNDs) are severe and common neurological complications among elderly patients following anesthesia and surgery. As the first line of defense of the innate immune system, Toll-like receptors (TLRs) have been found to be involved in the occurrence of neurodegenerative diseases in recent years. However, the role of TLR7 in the pathology and development of PNDs remains largely unclear.
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