Copper-Catalyzed Dienylation of Aldehydes Using Propargylic Carbonates.

A copper-catalyzed dienylation of aldehydes using propargylic carbonates in the presence of Bpin has been successfully developed, enabling the synthesis of a diverse range of substituted 1,3-butadienyl-2-carbinols (BDCs). This innovative approach circumvents the requirement of allene reagents and provides an alternative protocol that allows access to BDCs. In addition, the synthetic value of the products has been demonstrated in a series of further conversions, and the reaction mechanism has been proposed based on control experiments.

Regio- and Stereoselective Transfer Hydrogenation of Aryloxy Group-Substituted Unsymmetrical 1,2-Diketones: Synthetic Applications and Mechanistic Studies.

Developing a general method that leads to the formation of different classes of chiral bioactive compounds and their stereoisomers is an attractive but challenging research topic in organic synthesis. Furthermore, despite the great value of asymmetric transfer hydrogenation (ATH) in both organic synthesis and the pharmaceutical industry, the monohydrogenation of unsymmetrical 1,2-diketones remains underdeveloped. Here, we report the aryloxy group-assisted highly regio-, diastereo-, and enantioselective ATH of racemic 1,2-diketones.