Initial results in the automatic visual recognition of endometriosis lesions by artificial intelligence during laparoscopy: a proof-of-concept study.

Objective: To develop a machine learning method for the automatic recognition of endometriosis lesions during laparoscopic surgery and evaluate its feasibility and performance.

Design: Collecting and annotating surgical videos and training, validating, and testing a deep neural network.

Setting: Multicenter proof-of-concept study using surgical videos from expert centers in France, Hungary, Brazil, and Denmark.

Impact of a National Public Health Plan on the time frame for moderate and severe endometriosis diagnosis.

Objective: to study the time from symptom onset to the diagnosis of moderate and severe endometriosis and to compare this delay before and after the implementation of the French National Endometriosis Public Health Plan.

Design: Monocentric retrospective cohort study.

Exposure: A comparison of diagnostic delays for moderate and severe endometriosis in women before and after the implementation of a National Public Health Plan in February 2022.

[Breast cancer in women of childbearing age: Issues surrounding the role of hormones].

Breast cancer affects 5% of women of childbearing age, accounting for 30% of cancer cases in this population. These cancers are often more aggressive with a less favorable prognosis in younger women. Hormonal exposure plays a key role in the development of this cancer, although the specific impact of certain exposures, such as hormonal contraception or ovarian stimulation treatments, remains debated.

Laparoscopic multi-bipolar radiofrequency ablation of fibroids: impact on quality of life.

Objective: To evaluate the effectiveness of multi-bipolar radiofrequency ablation compared to standard laparoscopic myomectomy in treating uterine fibroids, focusing on women's quality of life.

Design: Retrospective observational cohort study.

Setting: La Conception Hospital, APHM-Marseille, France.

Uterine volume assay after gonadotoxic therapies in childhood, adolescence, and young adulthood: A systematic review and Bayesian network meta-analysis.

Introduction: Uterine damage after pelvic radiotherapy or total-body irradiation is well described, with decreased uterine volume and high obstetrical morbidity. Some recent studies have reported a smaller uterus in child, adolescent, and young adult cancer survivors treated with chemotherapy only. This systematic review investigated the long-term effects of gonadotoxic therapy on uterine volume during childhood, adolescence, and young adulthood.

Fertility preservation through oocyte or embryo vitrification prior to oncological treatment: a 12-year experience.

Purpose: Fertility preservation in women with cancer represents a major medical challenge at the intersection of oncological and reproductive concerns. With therapeutic advancements, the survival rates of cancer patients have significantly improved, offering the possibility of motherhood. Currently, there is a lack of data on the return of cryopreserved oocytes/embryos and pregnancy outcomes following cancer treatment.

Exploring fertility preservation in AYA cancer survivors: Information needs and post-cancer challenges.

Purpose: To explore the experiences of fertility preservation (FP) and cancer-induced infertility among adolescent and young adult (AYA) cancer survivors.

Methods: This cross-sectional, qualitative study was conducted by a sociologist in collaboration with a multidisciplinary team specializing in oncology and reproductive medicine. The sample included 31 AYA cancer survivors (13-35 years old) in remission for at least one year.

Development and validation of a model to identify polycystic ovary syndrome in the French national administrative health database.

Background: We aimed to develop and validate an algorithm for identifying women with polycystic ovary syndrome (PCOS) in the French national health data system.

Methods: Using data from the French national health data system, we applied the International Classification of Diseases (ICD-10) related diagnoses E28.2 for PCOS among women aged 18 to 43 years in 2021.

No impact of a positive Chlamydia trachomatis serology on live-birth rate after intra-uterine insemination.

Objective: To study the impact of a CT serology on intrauterine insemination (IUI) cumulative live-birth rate (cLBR) in women with documented bilateral tubal patency.

Design: Cohort study SUBJECTS: Infertile women with documented bilateral tubal patency and medical indication of IUI matched on the following criteria: woman's age, number of cycles completed and number of motile sperm inseminated (NMSI).

Exposure: This retrospective, observational and monocentric cohort study compared women with positive CT serology matched 1:1 to control women with negative CT serology.

Heterotopic ovarian transplantation instead hormonal replacement therapy after radical hysterectomy for cervical cancer: case report and review of literature.

Purpose: Only a few case reports have described heterotopic ovarian tissue transplantation (OTT) with the only objective of restoring ovarian function.

Methods: Case report and review of the literature for reporting cases of heterotopic OTT with the only aim of restoring ovarian endocrine function. In a cancer survivor woman with a history of hysterectomy and bilateral oophorectomy for cervical cancer and because she poorly tolerated hormone replacement therapy (HRT), we performed a heterotopic OTT in a pelvic subcutaneous "pocket" after an OT cryostorage of 17 years.

Impact of a positive Chlamydia trachomatis serology on cumulative IVF live birth rate.

Research Question: Does positive Chlamydia trachomatis serology have an impact on the cumulative live birth rate from IVF?

Design: A retrospective matched cohort study compared women with positive Chlamydia trachomatis serology (group A) who underwent IVF treatment between January 2016 and December 2021 with a control group of women with negative Chlamydia trachomatis serology (group B). The main outcome measures were the cumulative live birth rate per IVF cycle and the live birth rate per embryo transfer. Secondary outcomes were the cumulative rates of clinical pregnancy, ectopic pregnancy and pregnancy loss calculated per IVF cycle and per embryo transfer.

Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment.

The aim of our study was to evaluate the feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation after fertility-impairing treatment regardless of the initial disease. We conducted a cohort study based on population of women < 40 years of age with diminished ovarian reserve caused by fertility-impairing treatment (n = 129). Three groups of women were compared according to the type of initial disease: hematological malignancies, solid tumors, and benign diseases.

Impact of moderate-to-severe endometriosis on IVF cumulative live birth rate: a retrospective matched cohort study.

Research Question: Does moderate-to-severe endometriosis have an impact on cumulative live birth rates (cLBR) and IVF outcomes?

Design: In this retrospective matched cohort study, women with moderate-to-severe endometriosis undergoing IVF or intracytoplasmic sperm injection treatment from January 2015 to December 2020 were matched 1:2 to women with other causes of infertility (control group). The main outcome was cLBR per cycle and per woman, and secondary outcomes were number of oocytes retrieved and number of mature oocytes, fertilization rate, total number of embryos and usable embryos, implantation rate, clinical pregnancy rate and miscarriage rate per cycle.

Results: In total, 195 women with endometriosis were matched with 390 women without endometriosis (323 and 646 cycles, respectively).

[Restatement. Cancer and fertility preservation].

CANCER AND FERTILITY PRESERVATION. The integration of fertility preservation into the treatment pathway is a major issue for quality of life after cancer, particularly for very young children, adolescents and young adults. Responses must be adapted to age, gender and treatment.

Misconceptions and beliefs around hormone replacement therapy after childhood hematopoietic stem cell transplantation: A qualitative study among women leukemia survivors.

Purpose: After childhood leukemia and hematopoietic stem cell transplantation, hormone replacement therapy is often required to induce puberty because of premature ovarian insufficiency. Observance of this kind of treatment in adolescents and young women seems quite poor, and literature about its acceptance remains scarce; in order to learn about their experience and to better understand their attitude towards hormone replacement therapy, we used qualitative methods.

Design And Patients: 13 young women childhood cancer survivors completed an individual interview.

Ovarian Function and Spontaneous Pregnancy After Hematopoietic Stem Cell Transplantation for Leukemia Before Puberty: An L.E.A. Cohort Study.

Ovarian function impairment and infertility are among the most frequent late effects after hematopoietic stem cell transplantation (HSCT). The aim of this study was to evaluate ovarian function, occurrence of premature ovarian insufficiency (POI), and spontaneous pregnancy in a large cohort of adult survivor women who had undergone HSCT for leukemia before puberty. We conducted a retrospective observational study in women from the national cohort L.

Endometriosis, infertility and occupational life: women's plea for recognition.

The objective of this study was to explore and describe the specificities of the occupational life of infertile endometriotic women treated by in vitro fertilization. We conducted a qualitative monocentric study between December 2020 and June 2021. Twelve semi-structured in-depth interviews using a theme-based interview guide with open questions were undertaken with infertile women with deep infiltrating endometriosis.

Endometriosis and pregnancy: The illusion of recovery.

The objective of this study was to investigate the feelings and experiences of infertile women with deep infiltrating endometriosis during and after a first pregnancy achieved by in-vitro fertilization (IVF). We conducted a qualitative monocentric study between May and November 2020. Semi-structured interviews were undertaken with infertile women with deep infiltrating endometriosis who achieved a first pregnancy by IVF and delivered at least two years prior to the interview.

Anaerococcus ihuae sp. nov. and Mediannikoviicoccus vaginalis gen. nov., sp. nov., two new bacteria isolated from human vaginal samples.

Strains Marseille-Q5893 (= CSUR Q5893 = CECT 30496) and Marseille-Q5883 (= CSUR Q5883 = CECT 30497) were isolated from vaginal samples using the culturomics approach. The 16S rRNA gene sequences of each strain were sequenced and then compared by BLASTn to the NCBI database. Strains Marseille-Q5893 and Marseille-Q5883 were most closely related to Anaerococcus obesiensis and Finegoldia magna, with identities of 98.