Publications by authors named "Biteng Xu"
Gene signatures of m5C regulators may predict prognosis and immunity status of patients with Ewing's sarcoma.
Int Immunopharmacol
June 2025
Recent studies have showed that 5-methylcytosine (m5C) can be utilized to assess the prognosis of tumors. However, the role of clinical implications of m5C modification remains unclear. The mRNA expression profiles and clinical features were downed from GEO and ICGC databases.
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- Cuproptosis refers to a form of cell death triggered by copper, and this study explored how specific copper metabolism-related genes (CMRGs) might influence the dynamics of immune cell infiltration in Ewing's sarcoma (ES).
- The researchers analyzed mRNA expression data from various databases to identify 22 prognostic CMRGs, using statistical methods to categorize patients into high and low-risk groups based on gene expression and their impact on survival rates.
- A risk model was created identifying five key genes linked to lower survival rates in high-risk patients, with the model validated across additional datasets, and a nomogram developed to assist in predicting patient outcomes based on risk levels and clinical features.