Interplay between Polycomb-group associated histone modifiers and accessory proteins in plant evolution.

Epigenetic regulators are multiprotein complexes that modify chromatin architecture to control gene expression in response to developmental and environmental cues. These complexes function in a highly coordinated manner, often collaborating with various accessory proteins to precisely regulate the dynamic nature of chromatin states. However, our understanding of how these core histone-modifying regulators co-evolved with accessory proteins during plant evolution remains limited.

Utilizing meta-topolin for the micropropagation of high-yielding natural clones of (L.) Urban and evaluation of their anti-uropathogenic activity.

(L.) Urb., also known as Indian pennywort, is an important ethnomedicinal herb valued for its bioactive compounds, including asiaticoside, madecassoside, asiatic acid, and madecassic acid, collectively termed centellosides, which possess neuroprotective, wound-healing, and antioxidant properties In the present study, 87 accessions of were collected from six agro-climatic zones of West Bengal, India, and evaluated for centelloside content and bioactivity.

Solanum villosum Mill. an underutilized plant: establishment of hairy root culture and enhanced production of solasodine after elicitor treatment.

Solanum villosum Mill. is an underutilized traditional medicinal plant of the Solanaceae family. Solasodine is a steroidal glycoalkaloid chemical compound; it is an important secondary metabolite in this species and is widely utilized in various pharmaceutical industries due to its bioactive properties.

Enhancing secondary metabolite biosynthesis from ethnomedicinal plant Solanum nigrum L. through cytogenetically stable mass propagation, transgenic hairy root induction, and using different LED light and culture vessels for hairy root culture.

This study aimed for stepwise enhancement of bioactive compound production in ethnomedicinal plant Solanum nigrum through novel approaches of micropropagation, hairy root induction, and treatment of hairy roots with various physical conditions. Polyamines were first-time used for in vitro shoot multiplication of S. nigrum, where highest shoot numbers (55.

Elite genotype selection through antioxidant and antimicrobial activities, in vitro multiplication with -Topolin, genetic fidelity assessment via SCoT markers and cytological study, and chemo-profiling of selected elite genotype of Lam.: an underutilized alternative for nutrition and medicine.

Nowadays, the increasing world population and antibiotic resistance have become globally concerning issues. Lam. is an underexploited plant with multipurpose therapeutic and culinary uses and can be utilized as an alternative source of food and medicine.

Comparison of the rhizospheric soil bacteriomes of Oryza sativa and Solanum melongena crop cultivars reveals key genes and pathways involved in biosynthesis of ectoine, lysine, and catechol meta-cleavage.

Rice (Oryza sativa L.), Poaceae family, forms staple diet of half of world's population, and brinjal (Solanum melongena L.), an important solanaceous crop, are consumed worldwide.

Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System.

The goal of this study was to use coevaporation to look into how polyether compounds like mephenesin (MEP) can be encapsulated into the host molecule α-cyclodextrin's nanohydrophobic cage. Fourier transform infrared spectroscopy (FT-IR) investigations, powder X-ray diffraction (PXRD), and H NMR were among the spectroscopic techniques used to describe the inclusion complex. Additionally, Job's plot has been utilized to illustrate how MEP is encapsulated with α-cyclodextrin (α-CD) at a 1:1 molar ratio.

Secondary metabolite fingerprinting, anti-pathogenic activity, elite chemotype selection and conservation of - an ethnomedicinally underutilized species.

Roxb. is an ethnomedicinally important, essential oil (EO) yielding aromatic plant. A total of twelve accessions of this plant rhizome were collected from six different agro-climatic zones of West Bengal, India and evaluated for their antimicrobial activities against eight disease-causing, multi-drug-resistant pathogenic strains of urinary-tract infection and respiratory-tract infection.

Withania somnifera (L.) Dunal: Enhanced production of withanolides and phenolic acids from hairy root culture after application of elicitors.

Withania somnifera (L.) Dunal is an important indigenous medicinal plant with extensive pharmaceutical potential. The root is the main source of major bioactive compounds of this plant species including withanolides, withanine, phenolic acids, etc.

Investigation of intermolecular interactions of l-Valine and l-Phenylalanine with muscle relaxant drug mephenesin molecule prevalent in aqueous solution by various physico-chemical methods at T=298.15K-313.15K.

A complete chemical analysis of significant intermolecular interactions of l-Valine (L-Val) and l-Phenylalanine (L-Phe) with Mephenesin (MEPN) molecules in aqueous solution has been studied by different physicochemical methodologies at various temperatures ( = 298.15 K-313.15 K at an interval of 5 K) and concentrations (0.

Hairy root culture: a potent method for improved secondary metabolite production of Solanaceous plants.

Secondary metabolites synthesized by the Solanaceous plants are of major therapeutic and pharmaceutical importance, many of which are commonly obtained from the roots of these plants. 'Hairy roots', mirroring the same phytochemical pattern of the corresponding root of the parent plant with higher growth rate and productivity, are therefore extensively studied as an effective alternative for the production of these metabolites. Hairy roots are the transformed roots, generated from the infection site of the wounded plants with With their fast growth, being free from pathogen and herbicide contamination, genetic stability, and autotrophic nature for plant hormones, hairy roots are considered as useful bioproduction systems for specialized metabolites.

Sustainable production of plumbagin via -topolin-mediated high frequency regeneration of genetically true-to-type L.

L. is commonly known as chitrak, consumed since long time owing to its potent medicinal benefits. It is a major source of the yellow crystalline naphthoquinone called plumbagin, which is highly acclaimed for its anticancerous activities on different cancers i.

Exploration of Diverse Interactions of l-Methionine in Aqueous Ionic Liquid Solutions: Insights from Experimental and Theoretical Studies.

Here, we have investigated some physicochemical parameters to understand the molecular interactions by means of density (ρ) measurement, measurement of viscosity (η), refractive index( ) measurement, and conductance and surface tension measurements between two significant aqueous ionic liquid solutions: benzyl trimethyl ammonium chloride (BTMAC) and benzyl triethyl ammonium chloride (BTEAC) in an aqueous l-methionine (amino acid) solution. The apparent molar volume (Φ), coefficient of viscosity (), and molar refraction ( ) have been used to analyze the molecular interaction behavior associated in the solution at various concentrations and various temperatures. With the help of some important equations such as the Masson equation, the Jones-Doles equation, and the Lorentz-Lorenz equation, very significant parameters, namely, limiting apparent molar volumes (Φ , coefficient of viscosity (), and limiting molar refraction ( ), respectively, are obtained.

Groundwater quality enumeration and health risk in the extended part of Chhotanagpur granite gneiss complex of India.

The majority of people on the earth bank largely on groundwater to quench their thirst. In the era of rapid population growth, the over-exploitation of groundwater gives rise to water scarcity, and people find themselves in distress to manage safe drinking water. In this backdrop, the present study is carried out in the terrain of Pre-Cambrian igneous and high- to low-graded metamorphic rocks, to assess the groundwater potential zones (GWPZs) and evaluation of groundwater quality.

Host-Guest Encapsulation of RIBO with TSC4X: Synthesis, Characterization, and Its Application by Physicochemical and Computational Investigations.

In our present work, we synthesized a new encapsulated complex denoted as RIBO-TSC4X, which was derived from an important vitamin riboflavin (RIBO) and -sulfonatothiacalix[4]arene(TSC4X). The synthesized complex RIBO-TSC4X was then characterized by utilizing several spectroscopic techniques such as H-NMR, FT-IR, PXRD, SEM, and TGA. Job's plot has been employed to show the encapsulation of RIBO (guest) with TSC4X (host) having a 1:1 molar ratio.

Rural child health in India: the persistent nature of deprivation, undernutrition and the 2030 Agenda.

The 2030 Agenda for sustainable development was launched to achieve Sustainable Development Goals (SDGs) across the globe. This paper is based on the primary database to assess the nutritional status of 5-10 years children and the incidence of deprivation in their households of a backward district (Purulia), India in the context of the first two SDGs, no poverty and zero hunger. We conclude that around 74% of children are undernourished.

Exploring inclusion complex of an anti-cancer drug (6-MP) with β-cyclodextrin and its binding with CT-DNA for innovative applications in anti-bacterial activity and photostability optimized by computational study.

The co-evaporation approach was used to examine the host-guest interaction and to explore the cytotoxic and antibacterial properties of an important anti-cancer medication, 6-mercaptopurine monohydrate (6-MP) with β-cyclodextrin (β-CD). The UV-Vis investigation confirmed the inclusion complex's (IC) 1 : 1 stoichiometry and was also utilized to oversee the viability of this inclusion process. FTIR, NMR, and XRD, among other spectrometric techniques, revealed the mechanism of molecular interactions between β-CD and 6-MP which was further hypothesized by DFT to verify tentative outcomes.

Blind spots on western blots: Assessment of common problems in western blot figures and methods reporting with recommendations to improve them.

Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image display practices and a lack of detailed methods reporting can limit a reader's ability to evaluate or reproduce western blot results. While several groups have studied the prevalence of image manipulation or provided recommendations for improving western blotting, data on the prevalence of common publication practices are scarce.

Phytogenic silver nanoparticles from tissue-cultured Kaempferia angustifolia - an underutilized medicinal herb: a comparative antibacterial study on urinary pathogens.

Background: Ethnomedicinally important Kaempferia angustifolia is a rhizomatous aromatic herb belonging to the family Zingiberaceae. The present manuscript deals with the green synthesis of silver nanoparticles through a rapid reduction process mediated by the rhizome extract of tissue culture-raised plants. The present study was conducted to evaluate the antimicrobial activity of the bio-nanoparticles, and the plant extracts themselves against seven multidrug-resistant urinary tract infecting (MDR-UTI) pathogens.

Silver nanoparticle synthesis and their potency against multidrug-resistant bacteria: a green approach from tissue-cultured .

Drug resistance is a major concern nowadays, and finding alternatives of the well-known antibiotic is necessary. Green nanoparticles are emerging as a tenable alternative to this with a large spectrum of activity. The present manuscript describes an eco-friendly approach for green synthesis of silver nanoparticles from both in vitro and in vivo leaf extract of .

Probing the Molecular Assembly of a Metabolizer Drug with β-Cyclodextrin and Its Binding with CT-DNA in Augmenting Antibacterial Activity and Photostability by Physicochemical and Computational Methodologies.

The assembly of an inclusion complex in an aqueous medium using a metabolizer drug (dyphylline) as guest and β-cyclodextrin as host has been established, which is extremely appropriate for a variety of applications in modern biomedical sciences. The formation of the inclusion complex is established by H NMR, and surface tension and conductivity measurements demonstrate that the inclusion complex was produced with 1:1 stoichiometry. The thermodynamic parameters based on density, viscosity, and refractive index measurements were used to determine the nature of the complex.

Gully erosion vulnerability modelling, estimation of soil loss and assessment of gully morphology: a study from cratonic part of eastern India.

A highly visible form of soil erosion is gully, a significant geomorphological feature, resulting from water erosion and causing land degradation and deterioration. In arid and semi-arid environment, gully erosion is conceived as an important source of sediment supply washing out the top fertile soil and exposing lower soil layers. The present study is conducted on the lateritic terrain of Rupai watershed of eastern plateau fringe of India, where water erosion is a serious concern.

Application of a Multilayer Perceptron Artificial Neural Network for the Prediction and Optimization of the Andrographolide Content in .

Andrographolide, the principal secondary metabolite of , displays a wide spectrum of medicinal activities. The content of andrographolide varies significantly in the species collected from different geographical regions. Therefore, this study aims at investigating the role of different abiotic factors and selecting suitable sites for the cultivation of with high andrographolide content using a multilayer perceptron artificial neural network (MLP-ANN) approach.

Effect of different drying treatments on the physicochemical, functional, and antioxidant properties of .

(L.) Wettst is a very high-value medicinal plant that is commonly used for improving cognitive functions. However, the availability of very limited information on the drying method of has prompted to optimize a suitable drying method.

Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body.

In this study, umbelliferone and α-cyclodextrin host molecules have been mixed up through a coprecipitation method to prepare a supramolecular complex to provide physical insights into the formation and stability of the inclusion complex (IC). The prepared hybrid was characterized by H nuclear magnetic resonance (H NMR), Fourier transform infrared (FTIR) spectroscopy, electrospray ionization (ESI) mass spectrometry, DSC, and fluorescence spectroscopic studies. Job's plot provides a stoichiometric ratio of 1:1 and the Benesi-Hildebrand double reciprocal plot gives binding constant values using fluorescence spectroscopic titrations and the ESI mass data support the experimental observations.