Long Term Outcomes after Re-Irradiation With Spine Stereotactic Body Radiation Therapy: Single Institutional Retrospective Experience.

Re-irradiation of spinal metastases using stereotactic body radiotherapy (SBRT) presents clinical challenges, with limited patient outcomes data to guide decision-making. We report a retrospective, single-institutional experience of 107 lesions treated in 91 patients. 88 (72%) lesions were initially irradiated with conventional radiotherapy (median equivalent dose of 33Gy to the target, interquartile range, IQR: 23-35 Gy) with a median time to re-irradiation of 12 months (IQR: 4-21 months).

Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case report.

Epidermoid cysts (EC) are benign cystic lesions lined by squamous epithelium resulting from entrapped ectodermal elements during development. These can occur in various anatomic locations, including intracranial, intradiploic, spinal and in the superficial soft tissues. Although benign, these can grow or rupture, and mimic malignant tumor or infection.

Massive arachnoid granulation in the transverse sinuses on CT myelogram.

Giant arachnoid granulations have been previously reported in the literature, with the largest documented measuring 6 cm and usually associated with significant clinical symptoms. Herein, we present a patient with a massive, irregular-shaped arachnoid granulation occupying both transverse sinuses, a finding that has not yet been reported. The patient, who had a history of transvenous CSF-venous fistula (CVF) embolization, presented with persistent left occipital headaches.

Evaluation of Spontaneous Intracranial Hypotension Probabilistic Brain MRI Scoring Systems in Normal Patients.

Background And Purpose: Probabilistic brain MRI scoring systems have been introduced to stratify the likelihood of identifying a CSF leak at myelography in spontaneous intracranial hypotension (SIH). The Bern scoring system by Dobrocky and colleagues is now well recognized, with a scoring system by Benson and colleagues introduced more recently (referred to as the Mayo score in this study). Neither of these scoring systems have been thoroughly evaluated in patients without SIH.

Thermoprotection of Neural Structures During Musculoskeletal Ablation.

Percutaneous thermal ablation is widely used for local control and palliation of a variety of lesions throughout the musculoskeletal system. In this setting, safe ablation is predicated on the avoidance of unintentional injury to vulnerable neural structures that are often in proximity to ablation targets. This article highlights key periprocedural considerations in musculoskeletal ablation and reviews the array of active and passive thermoprotective measures that are critical to safe and successful treatment.

Development and validation of a recursive partitioning analysis-based pretreatment decision-making tool identifying ideal candidates for spine stereotactic body radiation therapy.

Background: This study was aimed at developing and validating a decision-making tool predictive of overall survival (OS) for patients receiving stereotactic body radiation therapy (SBRT) for spinal metastases.

Methods: Three hundred sixty-one patients at one institution were used for the training set, and 182 at a second institution were used for external validation. Treatments most commonly involved one or three fractions of spine SBRT.

Single and Multifraction Spine Stereotactic Body Radiation Therapy and the Risk of Radiation Induced Myelopathy.

Purpose: This study reports on the risk of radiation-induced myelitis (RM) of the spinal cord from a large single-institutional experience with 1 to 5 fraction stereotactic body radiation therapy (SBRT) to the spine.

Methods And Materials: A retrospective review of patients who received spine SBRT to a radiation naïve level at or above the conus medullaris between 2007 and 2019 was performed. Local failure determination was based on SPIne response assessment in Neuro-Oncology criteria.

Development and Internal Validation of a Recursive Partitioning Analysis-Based Model Predictive of Pain Flare Incidence After Spine Stereotactic Body Radiation Therapy.

Purpose: Pain flares are a common acute toxic effect after stereotactic body radiation therapy (SBRT) for spine metastasis. We aimed to identify a subset of patients with the highest rate of pain flare after spine SBRT to optimize prophylactic corticosteroid administration.

Methods And Materials: The data set included 428 patients with 610 treatments.

Development and Assessment of a Predictive Score for Vertebral Compression Fracture After Stereotactic Body Radiation Therapy for Spinal Metastases.

Importance: Vertebral compression fracture (VCF) is a potential adverse effect following treatment with stereotactic body radiation therapy (SBRT) for spinal metastases.

Objective: To develop and assess a risk stratification model for VCF after SBRT.

Design, Setting, And Participants: This retrospective cohort study conducted at a high-volume referral center included 331 patients who had undergone 464 spine SBRT treatments from December 2007 through October 2019.

Fanconi anemia: correlating central nervous system malformations and genetic complementation groups.

Background: Congenital central nervous system abnormalities in children with Fanconi anemia are poorly characterized, especially with regard to specific genetic complementation groups.

Objective: To characterize the impact of genetic complementation groups on central nervous system anatomy.

Materials And Methods: Through chart review we identified 36 patients with Fanconi anemia with available brain MRIs at the University of Minnesota (average age, 11.