Broadband continuous frequency-tunable narrow-linewidth laser based on self-injection locking to a miniaturized Fabry-Perot cavity.

We demonstrate a 1550 nm external-cavity diode laser (ECDL) based on a high-Q miniaturized Fabry-Pérot (FP) cavity, achieving a wide mode-hop-free continuous frequency-tuning range, which holds significant application value in fields such as frequency-modulated continuous-wave (FMCW) ranging and radar. By minimizing the feedback loop length and employing a piezoelectric transducer (PZT) to scan the cavity length, the continuous frequency-tuning range exceeds 30 GHz at a repetition rate of 100 Hz, with frequency-tuning nonlinearities of 1.7% and 1.

Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway.

Type 2 diabetes mellitus (T2DM) is a common and multiple endocrine metabolic disease. When pancreatic β cell in case of dysfunction, the synthesis and secretion of insulin are reduced. This study is to explore the effect of cordycepin (the molecular formula CHNO), a natural adenosine isolated from Cordyceps militaris, on high glucose/lipid-induced glucotoxicity and lipotoxicity in INS-1 cells.

Improving effect of cordycepin on insulin synthesis and secretion in normal and oxidative-damaged INS-1 cells.

Diabetes mellitus (DM) has recently become one of the major diseases that have received attention. Cordycepin (molecular formula: CHNO), is one of the major bioactive components of Cordyceps militaris, decreases blood glucose levels. In this study, the effect and mechanism of cordycepin in normal and oxidative-damaged INS-1 cells were explored by using cell and molecular biology methods.

Cordycepin suppresses glutamatergic and GABAergic synaptic transmission through activation of A adenosine receptor in rat hippocampal CA1 pyramidal neurons.

Cordycepin (known as 3-deoxyadenosine, CRD), a natural product from the valuable traditional Chinese medicine Cordyceps militaris, has been reported to improve cognitive function and modulate neuroprotective effects on the central nervous system (CNS). However, the modulating mechanisms of cordycepin on information processing in hippocampal CA1 pyramidal neurons are not fully understood. To clarify how cordycepin modulates synaptic responses of pyramidal neurons in rat hippocampal CA1 region, we conducted an electrophysiological experiment using whole-cell patch-clamp technique.

Doxorubicin-Loaded In Situ Gel Combined with Biocompatible Hydroxyethyl Cellulose Hemostatic Gauze for Controlled Release of Drugs and Prevention of Breast Cancer Recurrence Postsurgery.

Biodegradable hemostatic gauze used for surgical hemostasis has attracted great interest due to its excellent compliance and local anti-inflammatory and therapeutic effects when combined with drugs. Herein, we demonstrate the successful fabrication of water-soluble absorbed cellulose hemostatic material by introducing a biocompatible hydroxyethyl cellulose (HEC) hemostasis gauze into doxorubicin-loaded in situ gel (GEL(DOX)) for the prevention of breast cancer recurrence after surgical tumor resection. The present results show that HEC has a shorter metabolic period, no anaphylaxis and peripheral nerve toxicity, and possesses more advantages than oxidative regenerated cellulose hemostasis gauze, a commercially available product in market.