Sentence-level Relation Semantics Learning via Contrastive Sentences.

Sentence-level semantics plays a key role in language understanding. There exist subtle relations and dependencies among sentence-level samples, which is to be exploited. For example, in relational triple extraction, existing models overemphasize extraction modules, ignoring the sentence-level semantics and relation information, which causes (1) the semantics fed to extraction modules is relation-unaware; (2) each sample is trained individually without considering inter-sample dependency.

Network dysfunction precedes neurodegeneration in a dox-regulatable TDP-43 mouse model of ALS-FTD.

Neuronal hyperexcitability is a hallmark of amyotrophic lateral sclerosis (ALS) but its relationship with the TDP-43 aggregates that comprise the predominant pathology in over 90% of ALS cases remains unclear. Emerging evidence indicates that TDP-43 pathology induces neuronal hyperexcitability, which may contribute to excitotoxic neuronal death. To characterize TDP-43 mediated network excitability changes in a disease-relevant model, we performed in vivo continuous electroencephalography monitoring and ex vivo acute hippocampal slice electrophysiology in rNLS8 mice (males and females), which express human TDP-43 with a defective nuclear localization signal (hTDP-43ΔNLS).

Selection of geographical populations suitable for artificial breeding of the Northeast China Brown Frog (Rana dybowskii).

Amphibians, as a group greatly disturbed by human activities, are at increased risk of extinction. Rana dybowskii is an anuran species with both ecological and economic significance. Due to environmental changes and human overexploitation, it has been classified as Near-Threatened.

Effect of semaglutide on arrhythmic, major cardiovascular, and renal outcomes in patients with overweight or obesity: a systematic review and meta-analysis.

Background: Semaglutide has demonstrated potential in controlling hyperglycemia and lowering cardiovascular (CV) risk. However, its impact on arrhythmic, major CV, and renal outcomes is not well-defined. This systematic review and meta-analysis aimed to assess these effects in patients with overweight or obesity.

Tetrabromophthalate bis(2-ethylhexyl) ester (TBPH) exposure induces renal inflammation injury by activating MAVS-IRF3 signaling pathway in vitro and in vivo models.

Tetrabromophthalate bis(2-ethylhexyl) ester (TBPH) is a common brominated flame retardant, which exhibits environmental persistence, the potential for bioaccumulation, and concerning toxicological effects. But until now, there is limited data on TBPH-induced nephrotoxicity. Therefore, this study assessed the impact of TBPH exposure on renal cells and tissues through in vitro and in vivo models.