Perioperative Antimicrobial Strategies in Inflatable Penile Prosthesis Surgery: Associations Between Antifungals, Oral Antibiotics, and Intravenous Antibiotic Duration, and Infection Outcomes.

Purpose: This study aims to evaluate the association between antimicrobial practices, including oral antibiotics, IV antibiotics, antifungal prophylaxis, and infection outcomes in patients undergoing primary or revision inflatable penile prosthesis surgery.

Materials And Methods: We conducted a multicenter, retrospective cohort study of 5261 patients who underwent primary or revision inflatable penile prosthesis surgery at 16 specialized centers across the United States, Europe, and Korea from July 2016 to July 2021. Patient data included demographic and clinical characteristics, antibiotic and antifungal administration, and infection outcomes.

Unusual presentation of cowper gland adenocarcinoma Mimicking post-traumatic urethral stricture.

Urethral strictures are commonly attributed to trauma, inflammation, or iatrogenic causes, but malignancies are a rare etiology. We report a case of a 57-year-old male with a history of trauma presenting with a bulbomembranous urethral stricture, initially suspected as post-traumatic. Intraoperative frozen section analysis unexpectedly revealed Cowper gland adenocarcinoma, leading to definitive surgical management with radical cystoprostatectomy and urethrectomy.

Unveiling consumer interest and regional disparities: comparative analysis of online search trends for penile aesthetic procedures.

Background: Aesthetic procedures for penile enhancement, such as the Penuma silicone sleeve implant, have gained increasing attention for addressing concerns like perceived size, buried or retractile penis, and mild curvature.

Aim: To assess the online search interest over time for penile enhancement modalities, analyze the trends, and explore any regional disparities in search patterns.

Methods: Google Trends data from June 18, 2018, to June 11, 2023, were utilized to analyze search interest for Penuma, penile implant, penile girth, Hyaluronic acid (HLA) injection, and penis injection.

Inkjet-printed electronics for rapid and low-cost prototyping of digital microfluidic devices using an off-the-shelf printer.

Digital microfluidics (DMF) is revolutionizing point-of-care diagnostics by advancing lab-on-a-chip technology. To accelerate translation to real-life applications, it is crucial to devise rapid and low-cost methods for prototyping to test various design ideas. Here, we present one such method using an unmodified desktop inkjet printer and inexpensive materials.

SLNP-based CDK4- targeted nanotherapy against glioblastoma.

Introduction: Glioblastoma is a grade IV solid brain tumor and has a 15-month survival rate even after treatment. Glioblastoma development is heavily influenced by retinoblastoma protein (pRB) pathway changes. The blood-brain barrier, drug resistance, and severe toxicity of Temozolamide are key obstacles in treating glioblastoma.