Clathrin-Mediated Endocytosis for Enhanced Apoptosis Induction and Cellular Imaging in Triple-Negative Breast Cancer by Casein-Protected Blue-Emissive Carbon Dots.

The development of multifunctional nanoplatforms capable of drug delivery and real-time cellular imaging remains a key challenge in cancer theranostics. Herein, we report the development of a casein-protected maleic acid-derived nitrogen-doped carbon dot-based luminescent nanoplatform (MNCD@Cas NPs) for efficient delivery of the anticancer drug doxorubicin hydrochloride (DOX) to triple-negative breast cancer cells. Synthesized via a facile two-step method, the MNCD@Cas NPs exhibit bright blue fluorescence (λ = 390 nm), high water dispersibility, excellent colloidal stability, and substantial DOX loading capacity (∼84%) driven by electrostatic interactions.

Creating a designer cyanobacterial ecosystem for the sustainable production of biomass rich in sun-protecting compounds: mycosporine-like amino acids and scytonemin.

This review study examines an innovative biotechnological strategy aimed at creating a specialized cyanobacterial ecosystem designed to produce high-quality biomass abundant in compounds that provide protection against solar radiation, specifically scytonemin and mycosporine-like amino acids (MAAs). The remarkable ability of cyanobacteria to produce biomass that is both sustainable and environmentally friendly has attracted considerable attention in recent years, largely due to its wide-ranging applications in various industries. However, a significant challenge remains: the concentrations of these beneficial metabolites within cyanobacteria are typically very low, rendering industrial-scale production economically unviable.

EMC Effect of Tritium and Helium-3 from the JLab MARATHON Experiment.

Measurements of the EMC effect in the tritium and helium-3 mirror nuclei are reported. The data were obtained by the MARATHON Jefferson Lab experiment, which performed deep inelastic electron scattering from deuterium and the three-body nuclei, using a cryogenic gas target system and the high resolution spectrometers of the Hall A Facility of the Lab. The data cover the Bjorken x range from 0.

Cities Are Concentrators of Complex, MultiSectoral Interactions Within the Human-Earth System.

Cities are concentrators of complex, multi-sectoral interactions. As keystones in the interconnected human-Earth system, cities have an outsized impact on the Earth system. We describe a multi-lens framework for organizing our understanding of the complexity of urban systems and scientific research on urban systems, which may be useful for natural system scientists exploring the ways their work can be made more actionable.

Emergence of Dengue Virus Serotypes 1 and 3 in Mahottari and Adjacent Areas of Southern Nepal.

Dengue has been a serious public health concern in Nepal since the past few years, with concurrent big outbreaks occurring in 2022-2024. This cross-sectional study was conducted among febrile patients visiting hospitals in Mahottari district in southern Nepal. A total of 2141 dengue-suspected patients were investigated by routine laboratory assays and serological and molecular techniques, including real-time quantitative polymerase chain reaction (RT-qPCR).