Publications by authors named "Avneet Manghera"
Article Synopsis
- Hidradenitis suppurativa (HS) is a chronic skin condition marked by inflammation, where cytokines IL-17A and IL-17F are known to be elevated. A monoclonal antibody called bimekizumab targets both IL-17A and IL-17F to treat HS.
- The study utilized RNA sequencing on skin biopsies from HS patients to explore gene expression changes before and after bimekizumab treatment, revealing key genes related to neutrophil activity that are affected by the drug.
- Results showed that dual inhibition of IL-17A and IL-17F more effectively reduced HS-related gene expression and neutrophil movement in cultured cells than targeting either cytok
Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic disease.
J Allergy Clin Immunol
September 2023
Article Synopsis
- IL-17A is known to play a significant role in immune-mediated inflammatory diseases, while the function of IL-17F, which shares some similarity with IL-17A, is not well understood, though combining the inhibition of both shows potential benefits in treating psoriasis.
- In this study, researchers investigated how IL-17A and IL-17F are regulated in psoriatic disease using various advanced techniques, including RNA sequencing and a new cytokine-capture method.
- The findings highlight that IL-17F is expressed more than IL-17A in psoriatic conditions, with differing cell populations responsible for each isoform and their expression influenced by both inflammatory signals and medications, suggesting a need to target both IL-
Airway hyperresponsiveness (AHR) is a critical feature of wheezing and asthma in children, but the initiating immune mechanisms remain unconfirmed. We demonstrate that both recombinant interleukin-33 (rIL-33) and allergen [house dust mite (HDM) or ] exposure from day 3 of life resulted in significantly increased pulmonary IL-13CD4 T cells, which were indispensable for the development of AHR. In contrast, adult mice had a predominance of pulmonary LinCD45CD90IL-13 type 2 innate lymphoid cells (ILC2s) after administration of rIL-33.
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