Novel case of coexisting TCF3 and IGH gene rearrangement in pediatric B-cell acute lymphoblastic leukemia: Favorable response to steroids and standard chemotherapy.

B-ALL, a genetically heterogeneous disease, is predominantly characterized by translocations leading to the formation of chimeric fusion proteins, which are known leukemia drivers. These driver fusions along with some driver mutations form an important basis for 11 distinct and mutually exclusive genetic subgroups by WHO. This classification besides providing important insights into distinct disease biology also provides important prognostic and therapeutic guidance.

ISOT position statement on the feasibility of an organ for transplantation from brain-dead deceased donors: a Delphi consensus.

Organ shortage remains a critical challenge in India's transplant landscape, despite established deceased donor organ transplantation (DDOT) programmes. Many potentially viable organs from brain-dead deceased donors (DBDs) are discarded due to uncertainties surrounding donor suitability in specific clinical scenarios. To address this gap, the Indian Society of Organ Transplantation (ISOT) convened a panel of national experts to develop a Delphi consensus statement aimed at guiding transplant professionals on the feasibility of organ donation from DBDs, particularly in complex or marginal donor situations.

"Embracing a Borrowed Life": A Narrative Analysis of Post-Transplantation Experiences among Indian Kidney Recipients.

This study systematically examined the multifaceted dimensions of the posttransplantation experiences of Indian kidney recipients through a meticulous narrative analysis of clinical interview data sourced from 111 male and 28 female recipients. The mean age of recipients was 39.63 ± 11.

Efficacy of Regional Citrate versus Heparin Anticoagulation in Continuous Renal Replacement Therapy.

Background: Continuous renal replacement therapy (CRRT) is used in hemodynamically unstable patients with acute kidney injury (AKI). Heparin, the most commonly used anticoagulant, has a significant bleeding risk and is associated with heparin-induced thrombocytopenia. Regional citrate anticoagulation is an alternative anticoagulation strategy in CRRT.

Acquired resistance to immunotherapy in solid tumors.

Acquired resistance to immunotherapy (ARI) is a major challenge in solid tumors, limiting long-term success in up to 65% of patients who initially respond to immunotherapy. Defining ARI clinically remains complex, but ongoing efforts aim to establish standardized criteria. This review describes recent insights into ARI, revealing complex mechanisms involving both tumor-intrinsic mechanisms - such as antigen loss and presentation defects, interferon γ (IFNγ) insensitivity, tumor-mediated T cell exclusion, and metabolic reprogramming - as well as extrinsic factors such as inhibitory molecule upregulation, immunosuppressive cells, extracellular matrix (ECM) remodeling, and dysbiotic microbiota.

Immunohistochemical Expression of Survivin and Vascular Endothelial Growth Factor in Cervical Squamous Cell Carcinoma.

Uterine cervical cancer is the fourth leading cause of cancer death in women worldwide as per GLOBOCON (2020). In view of the higher incidence in the developing world and poor prognosis in cases presenting at advanced stage, there is an unmet need to explore new therapeutic targets for this neoplasm. Herein we sought to analyze and compare the immunoexpression of survivin (antiapoptotic factor) and vascular endothelial growth factor (VEGF).

Transparent Biomaterial-Based Nonvolatile Bioelectronic Memory with Excellent Endurance.

With the recent upsurge of data-driven technology, the demand for storage elements has pushed the researchers to explore design of nobel nonvolatile memory devices with diverse functionalities. However, the management of electronic waste has become a prominent challenge due to the rapid growth of the solid-state electronics industry. Biomaterial-based Resistive Random Access Memory (Bio-RRAM) has become one of the most promising devices that can augment the quality of memory devices because of their environmentally benign behavior, biocompatible, nontoxic, transient, transferable, flexible, dissolvable, and biodegradable nature.

An in-depth analysis of the impact of environmental drivers on the variability of phytoplankton community in the Arabian Sea during 2010-2021.

This study examines the long-term changes in phytoplankton size classes (PSCs) in the Arabian Sea (AS) using the remote sensing reflectance () data collected over 12 years (2010-2021) from the Moderate Resolution Imaging Spectroradiometer (MODIS). The spectra were inverted to chlorophyll-a (Chl-a) concentrations using a non-linear optimisation method, which were then used to estimate the PSC using a region specific three-component model. The analysis is carried out for all four seasons, , winter (December-February), pre-monsoon (March-May), monsoon (June-September) and post-monsoon (October-November).

Shear Wave Elastography as a Supplement Tool in Differentiating Benign and Malignant Axillary Lymph Nodes.

Objectives: To determine the efficacy of quantitative shear wave elastography in differentiating benign and malignant axillary lymph nodes (ALN).

Methods: Exactly 127 lymph nodes from 127 patients with clinically palpable axillary swelling were examined by both B-mode sonography and elastography from November 2022 to March 2024. Gray-scale sonograms were evaluated based on: the short-axis diameter, shape, hilum, maximum cortical thickness, and border of the ALN.

A Benign Lesion of Thyroid Masquerading as a Salivary Gland Malignancy on Cytology.

Introduction: Thyroid lesions are one of the most common diseases observed in clinical practice in the North India. These diseases have distinct cytological morphology and thus FNAC is done frequently. Here we report a case of adenomatoid goitre mimicking adenoid cystic carcinoma (ACC) of salivary gland on cytology.

NELL-1 Associated Membranous Nephropathy - A Case Series from India.

Neural epidermal growth factor-like 1 (NELL-1) is responsible for a substantial proportion of cases of PLA2R-negative primary membranous nephropathy (MN). To investigate the occurrence, association, and treatment responses, we carried out this ambispective study. In the study, nine (10%) of all patients with MN at our center were found to be NELL-1 positive.

CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC).

Multimodal therapy for peritoneal metastasis (PM) including cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provides long-term survival in highly selected colorectal cancer patients. Mechanisms behind HIPEC are unknown and may include induction of adaptive immunity. We therefore analyzed human PM samples and explored the impact of HIPEC in experimental models.

Evaluation of CTLA-4 and PD-L1 Expression in Thyroid Carcinoma and Its Prognostic Significance.

Introduction Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-ligand 1 (PD-L1) have revolutionised treatment and improved outcomes in various malignancies. We aimed to evaluate CTLA-4 and PD-L1 immunoexpression in thyroid tumours and correlated them with clinicopathological parameters. Methods The study included 90 cases of thyroid malignancies comprising papillary thyroid carcinoma (PTC) (n = 64, 54.

Enhancing Success in the ABO-Incompatible Kidney Transplantation: A Case Report.

Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD); however, ABO incompatibility (ABOi) poses challenges due to increased graft rejection risk. Desensitization strategies, including immunoadsorption (IA), aim to overcome ABOi barriers. The objective of this case report was to present the initial findings and patient outcomes of ABOi kidney transplantation (KT) using two different brands of IA columns (Glycosorb ABO and SECORIM-ABO) in reducing isoagglutinin titers to the desired target level.

Clinicopathologic Spectrum and Outcomes of Infections Diagnosed on Graft Biopsies and Nephrectomy in Live Renal Allograft Recipients: An Institutional Experience.

Objectives: Modern immunosuppressive regimens have reduced rejection episodes in renal allograft recipients but have increased the risk of opportunistic infections. Infections are considered to be the second leading cause of death after cardiovascular complications in renal allograft recipients. Data on opportunistic infections affecting the allograft itself are scarce.

ABO-Incompatible Renal Transplant: A Single-Center Experience from India.

Introduction: In view of ever-increasing end-stage renal disease (ESRD) population but inadequate availability of suitable donors, ABO-incompatible (ABOi) transplantation can be an important void filler. However, at present, ABOi transplantation is limited to a few centers in India and there is a lack of adequate experience and expertise to guide this program to other centers in the country.

Methods: Data of all the ABOi transplants performed from 2012 to 2021 in a tertiary care hospital was retrospectively analyzed.

Upstaging of Tuberculosis in the Post-COVID-19 Era: A Case Series.

The COVID-19 pandemic has significantly impacted the global health system as well as the social and economic impact on tuberculosis (TB) treatment and diagnostic services. A high volume of patients diagnosed and treated for TB were impacted by the pandemic restrictions, particularly reduced access to TB services provided by the National Tuberculosis Elimination Programme in India; this in turn increased the number of deaths due to TB. The Indian healthcare system has been struggling with the eradication of TB, and this additional worldwide health crisis caused by SARS-CoV-2 has put the Indian healthcare system under severe stress.

Clinico-pathological Factors in Malignant Transformation of RRP.

Various clinico-pathological factors play role in the papilloma proliferation and pathogenesis of Recurrent respiratory papillomatosis (RRP). However, it is not known if they are directly responsible for malignant transformation of these papillomas or not. We did this study to elucidate any such association.

Comparison of Clinico-pathologic features and outcomes of ANCA negative and ANCA positive pauci immune crescentic glomerulonephritis: A single centre study.

Introduction: Pauci-immune crescentic glomerulonephritis (PICN) is an important cause of rapidly progressive renal failure. 10-40% of PICN cases have ANCA (antineutrophil cytoplasmic antibody) negative serology. The present study compared clinico-pathologic features, Brix's renal risk score, Berden's histopathological classes and differences in outcome between ANCAnegative vs ANCA positive PICN patients.

Nocardiosis in Renal Transplantation: Case Series from India.

Nocardiosis is a rare opportunistic infection seen in kidney transplant patients and is caused by aerobic actinomycete. Disease manifestations can vary from a localized infection to multisystem organ failure. In this retrospective case series, we present 16 cases of Nocardiosis.

Heparin-Induced Thrombocytopenia in Hemodialysis Patients- The First Study from India.

Heparin-induced thrombocytopenia (HIT), a rare complication of heparin therapy, presents with thrombocytopenia. It leads to paradoxical thromboembolism and has high mortality if untreated. It is less recognized, especially in hemodialysis (HD) patients who are frequently exposed to heparin during dialysis because patients with renal failure may have many other causes of thrombocytopenia.