Designing Gel-Inspired Food-Grade O/W Pickering Emulsions with Bacterial Nanocellulose-Chitosan Complexes.

This study explored the potential of chitosan (CH)/bacterial cellulose (BC) complexes (0.5% /) as novel emulsifiers to stabilize oil-in-water (o/w) Pickering emulsions (20% / sunflower oil), with a focus on their gel-like behavior. Emulsions were prepared using CH combined with BNC derived via HSO (BNC1) or HSO-HCl (BNC2) hydrolysis.

Cyclodextrin-Based Quercetin Powders for Potential Nose-to-Brain Transport: Formulation and In Vitro Assessment.

Quercetin (Que) is widely recognized for its antioxidant and neuroprotective properties; however, its clinical potential remains limited due to poor solubility and low oral bioavailability. Nasal powders have emerged as a promising strategy to overcome these limitations, taking advantage of nose-to-brain delivery, offering a direct, non-invasive route to the central nervous system while bypassing first-pass metabolism. This study aims to extend previous work by systematically investigating the impact of different preparation methods (spray drying vs.

From bread waste to bacterial cellulose nanostructures: Development of a novel rotating disk bioreactor.

A novel rotating disk bioreactor was designed and manufactured to produce bacterial cellulose (BC) using Komagataeibacter rhaeticus. Optimal conditions-45 % disk submersion, mechanically etched disks with rotation speed of 20 rpm, spacing of 35 mm and 0.5 vvm air supply- achieved a yield of 1020 mg BC/disk with commercial glucose.

Efficient pectin recovery from sugar beet pulp as effective bio-based coating for Pacific white shrimp preservation.

This study demonstrates the valorization of sugar beet pulp (SBP)-derived pectin to produce bio-based coatings for shrimp preservation. Pectin extraction was assessed at varying temperatures and extraction times to achieve tailored properties (high methoxyl-pectins, degree of esterification-DE >79.0 %) leading to 11.

Hybrid Nanoparticles from Random Polyelectrolytes and Carbon Dots.

The present study concerns the preparation of hybrid nanostructures composed of carbon dots (CDs) synthesized in our lab and a double-hydrophilic poly(2-dimethylaminoethyl methacrylate--oligo(ethylene glycol) methyl ether methacrylate) (P(DMAEMA--OEGMA)) random polymer through electrostatic interactions between the negatively charged CDs and the positively charged DMAEMA segments of the polymer. The synthesis of P(DMAEMA--OEGMA) polymer was conducted through RAFT polymerization. Furthermore, the polymer was converted into a strong cationic random polyelectrolyte through quaternization of the amine groups of DMAEMA segments with methyl iodide (CHI), and it was subsequently utilized for the complexation with the carbon dots.

Stimuli-Responsive Self-Assembly of Poly(2-(Dimethylamino)ethyl Methacrylate-co-(oligo ethylene glycol)methacrylate) Random Copolymers and Their Modified Derivatives.

In this work, the synthesis and the stimuli-responsive self-assembly behavior of novel double-hydrophilic poly(2-(dimethylamino)ethyl methacrylate-co-(oligo ethylene glycol)methacrylate) random copolymers and their chemically modified derivatives are presented. The synthesis of P(DMAEMA-co-OEGMA) copolymers of different DMAEMA mass compositions was successfully conducted through RAFT polymerization, further followed by the hydrophilic/hydrophobic quaternization with methyl iodide (CHI), 1-iodohexane (CHI), and 1-iodododecane (CHI). The tertiary and quaternary amines are randomly arranged within the DMAEMA segment, responding thus to pH, temperature, and salt alterations in aqueous solutions.

Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications.

Over the last three decades, proteins and peptides have attracted great interest as drugs of choice for combating a broad spectrum of diseases, including diabetes mellitus, cancer, and infectious and neurological diseases. However, the delivery of therapeutic proteins to target sites should take into account the obstacles and limitations related to their intrinsic sensitivity to different environmental conditions, fragile tertiary structures, and short half-life. Polymeric nanostructures have emerged as competent vehicles for protein delivery, as they are multifunctional and can be tailored according to their peculiarities.