Personal exposure to air pollutants and immune system biomarkers in pregnant women.

The immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. One-week personal measurements of exposure to nitrogen dioxide (NO), particulate matter with an aerodynamic diameter of ≤ 2.5 µm mass concentration (PM) and PM oxidative potential (OP) were assessed in 270 pregnant women from the French cohort SEPAGES.

Oxidative potential of particulate matter and its association to respiratory health endpoints in high-altitude cities in Bolivia.

Exposure to particulate matter (PM) pollution is a significant health risk, driving the search for innovative metrics that more accurately reflect the potential harm to human health. Among these, oxidative potential (OP) has emerged as a promising health-based metric, yet its application and relevance across different environments remain to be further explored. This study, set in two high-altitude Bolivian cities, aims to identify the most significant sources of PM-induced oxidation in the lungs and assess the utility of OP in assessing PM health impacts.

Effects of personal exposure to the oxidative potential of PM on oxidative stress biomarkers in pregnant women.

Oxidative stress is a prominent pathway for the health effects associated with fine particulate matter (PM) exposure. Oxidative potential (OP) of PM has been associated to several health endpoints, but studies on its impact on biomarkers of oxidative stress remains insufficient. 300 pregnant women from the SEPAGES cohort (France) carried personal PM samplers for a week and OP was measured using ascorbic acid (AA) and dithiothreitol (DTT) assays, and normalized by 1) PM mass (OP) and 2) sampled air volume (OP).

Prenatal Exposure to Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study.

Background: Fine particulate matter () has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal oxidative potential (OP) on lung function in infants and preschool children.

Objectives: We estimated the associations of personal exposure to and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics.

Methods: We used data from 356 mother-child pairs from the SEPAGES cohort.

Personal exposure to PM oxidative potential and its association to birth outcomes.

Background: Prenatal exposure to fine particulate matter (PM) assessed through its mass concentration has been associated with foetal growth restriction in studies based on outdoor levels. Oxidative potential of PM (OP) is an emerging metric a priori relevant to mechanisms of action of PM on health, with very limited evidence to indicate its role on birth outcomes.

Objectives: We investigated the association of OP with birth outcomes and compared it with that of PM mass concentration.