The relationship between osteoporosis treatment history and receipt of a second zoledronic acid dose.

Unlabelled: We examined characteristics of patients in Ontario, Canada, initiating publicly funded zoledronic acid for osteoporosis from 2006 to 2021. Most patients had prior osteoporosis treatments, with those previously using oral bisphosphonates more likely to receive a second dose. Understanding treatment decisions and patient beliefs is key for future research.

Community Engagement in Long Covid Research: Process, Evaluation and Recommendations From the Long COVID and Episodic Disability Study.

Introduction: Long Covid and other infection-associated chronic condition communities have been integral in advocating for patient engagement in all stages of research, from design and conduct, and implementation, through to interpretation and knowledge translation; nevertheless, the process varies across research teams. In this paper, we (1) describe our process undertaking a community-engaged Long Covid research study; (2) evaluate our community-engaged approach, highlighting strengths and limitations with our process; and (3) identify recommendations for engaging in community-engaged patient-oriented research in Long Covid.

Methods: Guided by the 4PI (Principles; Purpose; Presence; Process; Impact) Framework and Patient-Led Research Scorecards, we describe our community-engaged approach within the Long COVID and Episodic Disability Study, followed by an evaluation of our community engagement using a multistage consultation with members of the Long COVID and Episodic Disability Study team.

Femur geometry influences atypical femoral fracture location.

Unlabelled: Bone geometry is thought to be an important factor in the development of atypical femoral fracture. Our three-dimensional analysis of whole-femur geometry indicates that lateral bowing influences fracture location. Lateral bowing may indeed play a role in AFF pathophysiology.

Respiratory oscillometry in individuals with fibrodysplasia ossificans progressiva.

Background: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic bone disease that is characterized by progressive heterotopic ossification of the thoracic cavity. Prognosis is poor with cardiopulmonary complications being the main cause of death. Spirometry is a well-established metric of functional exercise capacity and prognosis in lung diseases but its use is limited in this population.

Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.

This corrigendum is being published to correct a number of errors and imprecisions, on pages 113, 120-125 and 138, of the following article: Taher MK, Salzman T, Banal A, Morissette K, Domingo FR, Cheung AM, Cooper CL, Boland L, Zuckermann AM, Mullah MA, Laprise C, Colonna R, Hashi A, Rahman P, Collins E, Corrin T, Waddell LA, Pagaduan JE, Ahmad R, Jaramillo Garcia AP. Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence. Health Promot Chronic Dis Prev Can.

Antiresorptive Therapy to Reduce Fracture Risk and Effects on Dental Implant Outcomes in Patients With Osteoporosis: A Systematic Review and Osteonecrosis of the Jaw Taskforce Consensus Statement.

Objective: Placement of a dental implant in a patient on antiresorptive therapy has been hypothesized to increase the risk of medication-related osteonecrosis of the jaw (MRONJ) and/or impact implant survival. In patients with osteoporosis, the risk of MRONJ with antiresorptive therapy is only marginally higher than observed in the general population.

Methods: The International ONJ Taskforce conducted a systematic review of the literature and evaluated the outcomes of implant placement in individuals with osteoporosis receiving antiresorptive therapy.

Bone ultrasound fractal dimension theory and experimental analysis with application to early osteoporosis prediction in cancellous bone.

Fractal analysis and ultrasound techniques are pivotal in assessing osteoporosis by examining the complex structure of cancellous bone. Osteoporosis, marked by reduced bone mass and the degradation of bone microarchitecture, results in greater fragility and a higher risk of fractures. The poroelastodynamic model proposed in this study incorporates the Navier-Stokes equations of linear elasticity and Biot's theory of porous media, allowing the investigation of osteoporosis versus fractal dimension.

In menopause-related moderate-to-severe vasomotor symptoms not suitable for hormone therapy, fezolinetant safely improved symptoms.

GIM/FP/GP: [Formula: see text].

Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.

Introduction: We investigated the prevalence of new or persistent manifestations experienced by COVID-19 survivors at 3 or more months after their initial infection, collectively known as post-COVID-19 condition (PCC).

Methods: We searched four electronic databases and major grey literature resources for prospective studies, systematic reviews, authoritative reports and population surveys. A random-effects meta-analysis pooled the prevalence data of 22 symptoms and outcomes.

The Association Between Adjacent Forces and the Development of Proximal Junctional Kyphosis: A Musculoskeletal Analysis.

Study DesignBiomechanical modeling study.ObjectivesDespite several recognized risk factors for proximal junctional kyphosis (PJK), its causative mechanism remains unknown. There are limited biomechanical studies to elucidate the association of sagittal alignment with PJK.

Episodic disability framework in the context of Long COVID: Findings from a community-engaged international qualitative study.

Background: Increasing numbers of adults are living with the health-related consequences of Long COVID. The Episodic Disability Framework (EDF), derived from perspectives of adults living with HIV, characterizes the multi-dimensional and episodic nature of health-related challenges (disability) experienced by an individual. Our aim was to determine the applicability of the Episodic Disability Framework to conceptualize the health-related challenges experienced among adults living with Long COVID.

Impact of Pre-Existing Disability on Long-Term Health Care Use Following Hospitalization for COVID-19: A Population-Based Cohort Study.

Background: Emerging evidence shows the lasting impact of SARS-CoV-2 infection on health care use and needs. Policy-makers require data on population-level service use to understand patient needs and health system impacts following hospitalization for COVID-19.

Objective: To compare health service use within 12 months following hospitalization for COVID-19 among people with and without pre-existing disabilities, and to determine the extent to which such use is related to disability and other risk factors.

Lung transplantation and bone health: A narrative review.

Bone health after lung transplantation has not been comprehensively reviewed in over 2 decades. This narrative review summarizes the available literature on bone health in the context of lung transplantation, including epidemiology, presentation, and postoperative management. Osteoporosis is reported in approximately 30% to 50% of lung transplant candidates, largely due to disease-related impact on bone and lifestyle, and corticosteroid-related effects during end-stage lung disease (interstitial lung diseases, chronic obstructive pulmonary disease, and historically cystic fibrosis).

Prevalence of post-acute sequelae of SARS-CoV-2 infection in people living with HIV: a systematic review with meta-analysis.

Background: Given the chronic immune activation and inflammatory milieu associated with Long COVID and HIV, we assessed the prevalence of Long COVID in adults living with HIV; and investigated whether adults living with HIV were associated with increased chance of developing Long COVID compared to adults living without HIV.

Methods: In this systematic review and meta-analysis, we searched Medline, EMBASE, CINHAL, PubMed and CENTRAL from inception until June 14th, 2024, for observational studies that measured the prevalence of Long COVID in adults living with HIV and the odds of developing Long COVID following a SARS-CoV-2 infection in people living with HIV compared to people living without HIV. Reviews, case reports, randomised control trials and editorials were excluded.

The Role of Frailty and Myosteatosis in Predicting All-Cause Mortality in Older Adults with Cancer.

Frailty and myosteatosis are each prognostic of all-cause mortality (ACM) in patients with cancer. However, it is unclear whether myosteatosis adds value to frailty for predicting ACM. We assessed whether myosteatosis improves the predictive ability of frailty for ACM in older adults undergoing chemotherapy.

Prevalence of incomplete atypical femoral fractures using single energy absorptiometry after long-term anti-resorptive therapy.

Atypical femur fractures (AFFs) have been reported with long-term use of anti-resorptive drugs. Early identification is crucial because it allows early intervention to stop the progression to complete fracture, thus potentially reducing the ensuing burden. It has been shown that extending the scan image to take a full-length image of the femur (FFI) using single energy (SE) X-rays at the time of a dual-energy X-ray absorptiometry (DXA) scan can detect findings in the spectrum of AFF.

Comparison of long-term healthcare use among older adults with disabilities following hospitalization for COVID-19, sepsis, or influenza: a population-based cohort study.

Background: People with disabilities are at elevated risk of adverse short-term outcomes following hospitalization for acute infectious illness. No prior studies have compared long-term healthcare use among this high-risk population. We compared the healthcare use of adults with disabilities in the one year following hospitalization for COVID-19 vs.

Plasma taurine level is linked to symptom burden and clinical outcomes in post-COVID condition.

Background: A subset of individuals (10-20%) experience post-COVID condition (PCC) subsequent to initial SARS-CoV-2 infection, which lacks effective treatment. PCC carries a substantial global burden associated with negative economic and health impacts. This study aims to evaluate the association between plasma taurine levels with self-reported symptoms and adverse clinical outcomes in patients with PCC.

Outcomes following hip fracture surgery in adults with schizophrenia in Ontario, Canada: A 10-year population-based retrospective cohort study.

Objective: To understand immediate and long-term outcomes following hip fracture surgery in adults with schizophrenia.

Methods: Retrospective population-based cohort study leveraging health administrative databases from Ontario, Canada. Individuals aged 40-105 years with hip fracture surgery between April 1, 2009 and March 31, 2019 were included.

On-time denosumab dosing recovered rapidly during the COVID-19 pandemic, yet remains suboptimal.

Timely administration of denosumab every 6 mo is critical in osteoporosis treatment to avoid multiple vertebral fracture risk upon denosumab discontinuation or delay. This study aimed to estimate the immediate and prolonged impact of the COVID-19 pandemic on the timing of denosumab doses. We identified older adults (≥66 yr) residing in the community who were due to receive denosumab between January 2016 and December 2020 using Ontario Drug Benefit data.

Total serum pentosidine quantification using liquid chromatography-tandem mass spectrometry.

Pentosidine (PEN) is an Advanced Glycation End-product (AGE) that is known to accumulate in bone collagen with aging and contribute to fracture risk. The PEN content in bone is correlated with serum PEN, making it an attractive, potential osteoporosis biomarker. We sought to develop a method for quantifying PEN in stored serum.