Publications by authors named "Andrei Pop"

Introduction: Medical migration represents the movement of healthcare professionals from one country to another. The migration of Romanian doctors has evolved as a captivating and diverse phenomenon in the complex framework of global healthcare. As Romania struggles with its healthcare issues, many of its experienced medical personnel travel to foreign areas, lured by various factors ranging from economic concerns to the desire to gain clinical experience.

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Background: The EARLY TAVR trial (Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis) demonstrated that early transcatheter aortic valve replacement (TAVR) intervention was superior to clinical surveillance with delayed TAVR in patients with asymptomatic severe aortic stenosis. Cardiac biomarkers are associated with maladaptive remodeling, symptom onset, and worse outcomes after TAVR. Whether elevated biomarkers identify asymptomatic patients more likely to benefit from early intervention is unknown.

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To develop a deep learning model for esophageal motility disorder diagnosis using high-resolution manometry images with the aid of Gemini. Gemini assisted in developing this model by aiding in code writing, preprocessing, model optimization, and troubleshooting. The model demonstrated an overall precision of 0.

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Article Synopsis
  • Celiac disease (CD) is an autoimmune disorder caused by gluten that damages the small intestine, leading to nutrient absorption issues, and is often underdiagnosed.
  • This study investigated CD prevalence in Romania using the BIOHIT Celiac Quick Test with subsequent histological confirmation to better understand its demographic characteristics.
  • Out of 713 participants, 9 tested positive for CD, resulting in a prevalence of 1.26%, with younger individuals and a higher proportion of females affected, indicating a need for more research on regional differences in CD prevalence.
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Article Synopsis
  • - DGBI, including IBS, affects a large portion of the population, and while lactose intolerance is common in adults, self-reported symptoms often exaggerate the problem, affecting dietary choices and overall quality of life.
  • - A systematic review analyzed six studies involving 845 participants, highlighting that self-reported lactose intolerance has variable and only moderate accuracy compared to objective testing methods like hydrogen breath tests, leading to confusion in diagnosis.
  • - The review emphasizes the need for objective diagnostic tools and points out that lactose-free diets should not be universally recommended for IBS patients without clear evidence of lactose intolerance.
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Article Synopsis
  • Aortic stenosis is the most common heart valve disease in the West, traditionally treated with surgical aortic valve replacement (SAVR) but now increasingly with transcatheter aortic valve replacement (TAVR).
  • Patients over 65 usually receive bioprosthetic tissue valves, and there's uncertainty in choosing between TAVR and SAVR.
  • The management of patients with bioprosthetic valves should be personalized based on individual anatomy and overall risk to enhance life expectancy and reduce long-term complications.
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Objectives: The aim of this study was to compare transcaval and transaxillary artery access for transcatheter aortic valve replacement (TAVR) at experienced medical centers in contemporary practice.

Background: There are no systematic comparisons of transcaval and transaxillary TAVR access routes.

Methods: Eight experienced centers contributed local data collected for the STS/ACC TVT Registry (Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry) between 2017 and 2020.

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Background: Transcatheter aortic valve replacement (TAVR) with a standardized clinical pathway allows most patients to achieve safe next-day discharge. This approach has been successfully implemented across global centers as part of the Benchmark Program. Considering restricted hospital resources resulting from the COVID-19 pandemic, a modified same day discharge (SDD) clinical pathway was implemented for selected TAVR patients at a single Benchmark site.

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Objectives: The aim of this study was to determine the safety and efficacy of same-day discharge (SDD) after transcatheter aortic valve replacement (TAVR) during the COVID-19 pandemic.

Background: The COVID-19 pandemic has placed significant stress on health care systems worldwide. SDD in highly selected TAVR patients can facilitate the provision of essential cardiovascular care while managing competing COVID-19 resource demands.

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Analysis of serum biomarkers for the assessment of atrophic gastritis (AG), considered as precursor of the intestinal type of gastric cancer, is of growing interest. The combination of pepsinogen (PG), gastrin-17 (G17) and anti- () antibody serological assays (panel test) is a non-invasive tool for the diagnosis of atrophic gastritis. However, the diagnostic reliability of this test remains uncertain.

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Objectives: This study sought to determine the safety of the BASILICA (bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction) procedure.

Background: Transcatheter aortic valve replacement causes coronary artery obstruction in 0.7% of cases, with 40% to 50% mortality.

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Background And Aims: The nonpharmacological therapy in irritable bowel syndrome (IBS) is expanding rapidly. Practitioners and medical educators need to be aware of progress and changes in knowledge of this topic. The Romanian Society of Neurogastroenterology aimed to create guidelines based on best evidence on the use of nonpharmacological therapy in IBS.

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Background And Aims: The three manometric patterns of achalasia are considered by some authors as different stages in the evolution of the same disorder. The aims of our study were to characterize patients with achalasia, in order to find key differences supporting the idea of progression from one type to the other, and to assess the clinical evolution in time.

Methods: From 280 high resolution esophageal manometry recordings we selected unique patients with achalasia.

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Introduction: Studies regarding antibiotics administration during pregnancy and atopic dermatitis (AD) in children are only few. In this context, the objective of our study was to investigate the potential association between the timing of intrauterine exposure to antibiotics or prenatal antibiotic administration in general and AD occurrence in children.

Methods: This was a cross-sectional study in 1046 subjects.

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Purpose: The presence of calcification in the iliac arteries is associated with decreased procedural success and increased complication risk during endovascular intervention. The objective of this study was to evaluate the safety and efficacy of peripheral intravascular lithotripsy (IVL) during endovascular treatment of iliac arterial peripheral artery disease (PAD).

Methods: The Disrupt PAD III Observational Study is a prospective, non-randomized, multi-center single-arm study to assess the 'real-world' safety and effectiveness of the Shockwave Peripheral IVL System for the treatment of de novo calcified lesions in the peripheral arteries, with a goal of treating 1500 patients.

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Despite improvements in the conventional preoperative tools used for staging of gastric cancer, their accuracy still needs to be improved. Laparoscopy has the potential to visualize and characterize the tumor, the peritoneal cavity and the lymph nodes and thus to better select patients for the optimal treatment strategy. Material and Method: Patients with gastric cancer staged initially with contrast enhanced computer tomography and endoscopic ultrasound were also evaluated by laparoscopy and laparoscopic ultrasound in a distinct preoperative staging procedure.

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Background: Insulin resistance (IR) is present in type 1 diabetes mellitus (T1DM) and is suggested to be related to chronic diabetic complications. The primary aim of our study was to assess IR in T1DM patients with and without chronic complications. A secondary aim was to evaluate the possible association between IR and chronic diabetic complications.

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