Retinal ganglion cell function in AQP4+ and MOG+ optic neuritis.

Aim: To compare retinal ganglion cell function between optic neuritis (ON) cases positive for anti-aquaporin-4 antibody (AQP4+) and myelin oligodendrocyte glycoprotein (MOG+).

Methods: Patients tested positive for AQP4 or MOG and history of ON at least six months prior to enrollment were included. An ophthalmological examination, visual acuity test (BCVA), visual field test (mean deviation, MD) and spectral-domain optical coherence tomography (OCT) were performed.

Descemet membrane endothelial keratoplasty combined with secondary sulcus hydrophobic intraocular lens implantation.

Purpose: To report a case of combined Descemet membrane endothelial keratoplasty (DMEK) and secondary sulcus hydrophobic intraocular lens (IOL) implantation for hyperopic correction in a pseudophakic eye with Fuchs' endothelial corneal dystrophy.

Observation: A 74-year-old woman with Fuchs' dystrophy and a history of phacoemulsification with a hydrophilic IOL in her left eye (refraction: +5.25 D/-1.

Refraction Predictability for a Capsulotomy-Fixated Intraocular Lens in Femtosecond Laser-Assisted Cataract Surgery.

Purpose: To evaluate the predictability of postoperative refraction for a capsulotomy-fixated intraocular lens (IOL) after femtosecond laser-assisted cataract surgery (FLACS).

Methods: Patients with age-related cataracts and no other eye disease who were implanted with the FEMTIS FB-313 IOL (Teleon Surgical BV) during FLACS were included. Using an IOLMaster 700 (Carl Zeiss Meditec), subjective refractive and biometric data were collected preoperatively and at a minimum of 3 months postoperatively.

Visual Outcomes and Clinical Features of Extensive Macular Atrophy with Pseudodrusen (EMAP).

Purpose: To describe extensive macular atrophy with pseudodrusen (EMAP) using multimodal imaging and analyze factors associated with visual loss.

Methods: This observational case seriesretrospectively reviewed the clinical and multimodal imaging (color fundus photography [CFP], fluorescein angiography, fundus autofluorescence (FAF), and optical coherence tomography [OCT]) of patients between January and December 2023. The EMAP diagnosis was based on early-onset macular atrophy, pseudodrusen, and bilateral disease.

Adaptive optics cone arrangement in hydroxychloroquine users without signs of retinal toxicity based on current screening guidelines: a case-control study.

Purpose: To describe early cone changes detected by adaptive optics (AO) in patients on chronic hydroxychloroquine (HC) treatment with no abnormalities on standard functional or structural retinal tests.

Methods: Case-control study including 36 eyes of 36 female patients. Cases included 18 women on HC for autoimmune disease whose cumulative dose exceeded 1600 g and who demonstrated no evidence of retinal toxicity on visual field (VF), spectral domain optical coherence tomography (SD-OCT), or multifocal electroretinography (mfERG).

Clinical Outcome of Endothelium-Outward Preloaded Descemet Membrane Endothelial Keratoplasty in Long-Term Dextran-Containing Transport Medium Preservation.

Purpose: To analyze the clinical outcome of organ-cultured endothelium-outward preloaded DMEK (pDMEK) using the RAPID cartridge.

Methods: This prospective study included 80 eyes of 80 patients who received a pDMEK. Best-corrected visual acuity (BCVA), endothelial cell count (ECC), and central corneal thickness were measured preoperatively and 4 to 6 weeks, 3 months, 6 months, and 1 year postoperatively.

Myopic shift in pediatric cataract surgery associated with age and surgical complications.

Purpose: To investigate predictors for myopic shift after pediatric cataract surgery after at least 3 years follow-up.

Study Design: Cross-sectional and retrospective study.

Methods: This study included patients treated for congenital or infantile cataract operated up to 5 years of age between 2010 and 2017.

Long-term astigmatism after intraocular pressure sensor implantation and nonpenetrating glaucoma surgery: EYEMATE-SC trial.

Purpose: To investigate long-term astigmatism after combined nonpenetrating glaucoma surgery (NPGS) and implantation of the first miniaturized suprachoroidal intraocular pressure (IOP) sensor EYEMATE-SC.

Setting: The study was conducted in 5 medical centers in 2 different countries.

Design: Retrospective multicenter clinical study.

Saccadic movements during an exploratory visual search task in patients with glaucomatous visual field loss.

Purpose: To evaluate the saccadic movements of patients with visual field loss due to primary open-angle glaucoma.

Methods: Thirteen patients with good visual acuity (0.2 logMAR or better) (seven patients with primary open-angle glaucoma 65 ± 13 years) and six controls (51 ± 6 years) yielded a comprehensive ophthalmological examination, including Humphrey Visual Field tests (SITA-Standard 24-2), and performed a monocular, exploratory digital visual search task that quantifies the duration for finding the number "4" on a random array of digits distributed on the screen.

Clinical spectrum of myelin oligodendrocyte glycoprotein antibody-associated disease in Brazil: a single-center experience.

Background:  Anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibody-associated disease (MOGAD) is an immune-mediated neurological disorder with a broad spectrum of clinical presentation that is often difficult to distinguish from other demyelinating diseases, such as multiple sclerosis and neuromyelitis optica spectrum disorder.

Objective:  To describe the clinical and paraclinical characteristics of MOGAD in a Brazilian tertiary center.

Methods:  We retrospectively reviewed the records of adult and pediatric patients who tested positive for anti-MOG antibodies and presented with clinical and radiological diseases compatible with MOGAD.

Visual performance and photic disturbances with diffractive and nondiffractive EDOF intraocular lenses using mini-monovision: randomized trial.

Purpose: To compare visual performance and photic visual disturbances of patients implanted with 2 different extended depth-of-focus (EDOF) intraocular lenses (IOLs) using mini-monovision.

Setting: Ambulatory surgical center at the University of São Paulo in Ribeirão Preto, Brazil.

Design: Prospective, examiner-masked, randomized clinical trial.

Strabismus development after pediatric cataract surgery associated with age at surgery, intraocular lens implantation, and visual acuity outcome.

Purpose: Approximately half of the children operated on for cataracts develop strabismus. We determined what factors predict its development.

Methods: In a retrospective, cross-sectional study, children who underwent cataract surgery before age 5 between 2010 and 2017 in a tertiary center in Brazil were identified from medical records.

Intravitreal acetazolamide implant for pseudophakic cystoid macular edema.

Background: Pseudophakic cystoid macular edema (PCME) is the most common cause of visual acuity deterioration after uncomplicated cataract surgery. There is no consensus regarding how to manage recurrent or refractory cases.

Report: A 54-year-old woman complained of decreased vision and central metamorphopsia in the right eye (OD) 3 months after uneventful cataract surgery.

Intravitreal bevacizumab plus propranolol for neovascular age-related macular degeneration (the BEVALOL study): a phase I clinical trial.

Background: Given the persistently large public health impact of neovascular age-related macular degeneration (nARMD) despite many years of anti-VEGF therapy as the first-line treatment and the demonstrated ability of b-blockers to reduce neovascularization, a synergistic effect between an anti-VEGF agent and an intravitreal beta-blocker is important to investigate in the quest for therapeutic alternatives that maximize efficacy and/or reduce costs. The main purpose of this study is to investigate the safety of a 0.1 ml intravitreal injection of a combination of bevacizumab (1.

Safety of intravitreal metoprolol in eyes with central serous chorioretinopathy.

Purpose: To investigate ocular safety of intravitreal metoprolol in eyes with central serous chorioretinopathy.

Methods: Five eyes of five patients diagnosed with chronic central serous chorioretinopathy (cCSC) previously treated unsuccessfully with oral spironolactone, micropulse laser and intravitreal anti-vascular endothelial growth factor agents were enrolled and received off-label intravitreal metoprolol (50 µg/0.05 ml).

Comprehensive variant spectrum of the CNGA3 gene in patients affected by achromatopsia.

Achromatopsia (ACHM) is a congenital cone photoreceptor disorder characterized by impaired color discrimination, low visual acuity, photosensitivity, and nystagmus. To date, six genes have been associated with ACHM (CNGA3, CNGB3, GNAT2, PDE6C, PDE6H, and ATF6), the majority of these being implicated in the cone phototransduction cascade. CNGA3 encodes the CNGA3 subunit of the cyclic nucleotide-gated ion channel in cone photoreceptors and is one of the major disease-associated genes for ACHM.

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update.

Myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated optic neuritis has been established as a new entity of immune-mediated optic neuropathy. Patients usually present with recurrent optic neuritis, often bilaterally with initially severe vision loss and optic disc edema. However, in contrast to aquaporin 4-IgG-seropositive neuromyelitis optica spectrum disorder, visual recovery tends to be more favorable, with good response to steroid treatment.

Decreased Retinal Sensitivity Overlying Choroidal Nevi.

Purpose: To report retinal function findings on the choroidal nevus.

Methods: Prospective descriptive case series of 7 patients ( = 7 eyes) presenting a melanocytic choroidal lesion consistent with choroidal nevus and no other ocular disease. Baseline evaluation included measurement of best-corrected visual acuity (BCVA), color and near-infrared fundus pictures, and spectral-domain OCT (Heidelberg Engineering).

Proliferative diabetic retinopathy treated with intravitreal ranibizumab and photocoagulation directed at ischemic retinal areas-A randomized study.

Purpose: To compare ETDRS panretinal laser photocoagulation (PRP) combined with intravitreal injection of ranibizumab (IVR) and photocoagulation targeted to ischemic retina (PIR) combined with IVR in patients with proliferative diabetic retinopathy (PDR).

Methods: PDR patients were randomly assigned to treatment with either PRP + IVR or PIR + IVR. ETRDS Best-corrected visual acuity (BCVA) and central subfield thickness (CSFT) measured on optic-coherence tomography images (OCT-Heidelberg Spectralis) were recorded at baseline and every 4 weeks for one year.

Intravitreal metoprolol for circumscribed choroidal hemangiomas: a phase I clinical trial.

Background: Choroidal hemangioma is a visual threatening condition for which treatments is neither uniform nor widely available. New management options are necessary. The purpose of this study is to assess the safety and early outcome of intravitreal metoprolol tartrate in five patients with CCH.

Influence of pupillary dynamics on the defocus curve of eyes implanted with diffractive multifocal lenses: a randomized study.

Purpose: To evaluate the influence of pupil dynamics on the defocus profile and area-of-focus of eyes implanted with a diffractive multifocal intraocular lens (IOL).

Methods: This prospective randomized trial was conducted at the Department of Ophthalmology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Thirty-eight patients were randomly assigned to receive the multifocal SN6AD1 (n=20) or the aspheric monofocal SN60WF (aIOL) (n=18) IOLs bilaterally.