Prevalence of Celiac Disease in Patients With Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis.

Celiac disease (CeD) has been linked to both autoimmunity and chronic liver disease, but most data on the link to primary biliary cholangitis (PBC) originate from small studies and have yielded conflicting results. A systematic search was performed in the databases of Medline, Embase, Cochrane and Web of Science Core Collection for studies published between 1990 and 2024, using search terms related to CeD, gluten and PBC. The search identified 2016 publications, of which 94 were read in full text.

Pancreatic Exocrine Insufficiency Is Not Uncommon in Celiac Disease: A Systematic Review and Meta-Analysis.

Introduction: Pancreatic exocrine insufficiency (PEI) is seen in primary pancreatic disease but has also been seen in extrapancreatic conditions including celiac disease (CeD). The symptoms of PEI and CeD often overlap, which makes diagnostics challenging. In this systematic review and meta-analysis, we aimed to investigate the prevalence of PEI in CeD.

Prevalence of Joint Complaints in Patients with Celiac Disease: A Systematic Review and Meta-Analysis.

: Current evidence suggests that joint complaints can represent an extra-intestinal manifestation in patients with Celiac Disease (CD) without any rheumatic comorbidity. However, the prevalence of joint complaints in the context of both CD and rheumatic disease is not known. The aim of this study was to estimate the prevalence of joint complaints in patients with CD.

Global evolution of inflammatory bowel disease across epidemiologic stages.

During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin America, while the prevalence in early industrialized regions continued to grow steadily. Changes in the incidence and prevalence denote the evolution of IBD across four epidemiologic stages: stage 1 (emergence), characterized by low incidence and prevalence; stage 2 (acceleration in incidence), marked by rapidly rising incidence and low prevalence; and stage 3 (compounding prevalence), where the incidence decelerates, plateaus or declines while the prevalence steadily increases.

Increased Risk of Cardiovascular Events After Coronary Interventions in Inflammatory Bowel Disease: A Nationwide Matched Cohort Study.

Background: Inflammatory bowel diseases (IBD) have been associated with an increased long-term risk of coronary artery disease due to chronic systemic inflammation.

Aim: To evaluate the risk of major adverse cardiovascular events (MACE) after coronary interventions.

Methods: In this nationwide cohort study of adults undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) (2012-2022), patients with IBD were propensity score-matched 1:10 to comparators without IBD.

Adult-onset inflammatory bowel disease and the risk of venous thromboembolism - a Swedish nationwide cohort study 2007-2021.

Background: Earlier studies, mainly prior to the widespread use of advanced therapy and implementation of guidelines for thromboprophylaxis indicate a doubled risk of venous thromboembolism (VTE) in patients with inflammatory bowel disease (IBD).

Methods: Using Swedish healthcare registers, we identified a population-based cohort of patients with incident IBD 2007-2021. Patients were matched by age, sex, calendar year of birth and place of residence with up to 10 reference individuals.

Statin Use is Associated with a Less Severe Disease Course In Inflammatory Bowel Disease: A Nationwide Cohort Study 2006-2020.

Background: Statins reduce the risk of inflammatory bowel disease (IBD), however their effect on IBD disease progression is largely unknown.

Methods: We linked Swedish healthcare registers and performed a nationwide cohort study (2006-2020) of 19 788 adults (≥18 years) with ulcerative colitis (UC) and 12 582 with Crohn's disease (CD). Of these, 1733 with UC and 962 with CD were identified as incident statin users after UC or CD diagnosis.

All-cause and Cause-specific Mortality in Achalasia: A Nationwide Matched Cohort Study.

Background & Aims: Achalasia has been linked to increased mortality, but evidence from large population-based cohorts is scarce. We aimed to assess mortality in individuals with achalasia.

Methods: This nationwide cohort study included all adults in Sweden with incident achalasia (n = 704; 1969-2017; follow-up until December 31, 2021) without any other prior esophageal conditions.

Microscopic Colitis and Risk of Venous Thromboembolism: A Nationwide Matched Cohort Study.

Introduction: Inflammatory diseases have been associated with increased risk of venous thromboembolism (VTE). However, data on VTE are lacking in large population-based cohorts of microscopic colitis (MC).

Methods: This study included all Swedish adults with incident MC without prior VTE (1990-2017; n = 12,489; follow-up until 2021).

Substantial Reduction of Systemic Corticosteroid Use After Primary Ileocaecal Resection in Swedish Patients With Crohn's Disease: A Population-Based Cohort Study.

Background: The corticosteroid-sparing effects of ileocaecal resection have not been thoroughly investigated in a population-based cohort.

Aim: To investigate systemic corticosteroid use before and after primary ileocaecal resection in patients with Crohn's disease.

Methods: Through nationwide registries, we identified 1565 patients with Crohn's disease undergoing primary ileocaecal resection in Sweden 2006-2019.

Risk of Major Adverse Cardiovascular Outcomes in Families With MASLD: A Population-Based Multigenerational Cohort Study.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a risk factor for cardiovascular disease. However, whether family members of individuals with MASLD also share an increased cardiovascular risk is unknown.

Methods: We created a nationwide multigenerational cohort study identifying all family members of Swedish adults diagnosed with biopsy-proven MASLD (1969-2017) and of matched general population comparators (by age, sex, calendar year, and county of residence).

A nationwide cohort study of inflammatory bowel disease, histological activity and fracture risk.

Background: Individuals with inflammatory bowel disease (IBD) are at increased risk of fracture. It is unclear if this risk varies by recent histological activity.

Aims: To determine the fracture risk in IBD during periods with and without histological inflammation.

Diverticular disease and risk of incident major adverse cardiovascular events: a nationwide matched cohort study.

Background: An increased risk of cardiovascular disease (CVD) has been reported in patients with diverticular disease (DD). However, there are knowledge gaps about specific risks of each major adverse cardiovascular event (MACE) component.

Methods And Results: This nationwide cohort study included Swedish adults with DD (1987-2017, N = 52 468) without previous CVD.

Eosinophilic esophagitis and risk of incident major adverse cardiovascular events: a nationwide matched cohort study.

Background: Inflammatory diseases have been associated with an increased cardiovascular risk. However, data on incident major adverse cardiovascular events (MACE) from large population-based cohorts of patients with eosinophilic esophagitis (EoE) is lacking.

Methods: This study included all Swedish adults with EoE without a record of previous cardiovascular disease (CVD) (1990-2017, N = 1546) with follow-up until 2019.

Risk of Kidney Failure in Patients With Inflammatory Bowel Disease Undergoing Colectomy: A Nationwide Cohort Study.

Background & Aims: Inflammatory bowel disease (IBD) is frequently accompanied by kidney complications. Potential triggers or subpopulations at high-risk of kidney problems are not well-elucidated. We hypothesized that surgical interventions, specifically colectomy, might in part explain this risk.

Acute interstitial nephritis in patients with inflammatory bowel disease treated with vedolizumab: a systematic review.

Background: Acute interstitial nephritis (AIN) is a complication of drugs that may cause permanent kidney injury. AIN has been reported in patients with inflammatory bowel disease (IBD) treated with the integrin inhibitor vedolizumab. Through systematic review of existing literature, we aimed to identify and describe cases of AIN in patients with IBD treated with vedolizumab.

Impact of inflammatory bowel disease on the risk of acute coronary syndrome: A Swedish Nationwide Cohort Study.

Background: There are conflicting data on the risk of acute coronary syndrome (ACS) in patients with inflammatory bowel disease (IBD). Only a few previous reports include patients diagnosed during the last decade.

Aim: To assess and compare the risk of ACS between patients with IBD and the general population.

Histologic Activity in Inflammatory Bowel Disease and Risk of Serious Infections: A Nationwide Study.

Background & Aims: Individuals with inflammatory bowel disease (IBD) are at increased risk of serious infections, but whether this risk varies by histologic disease activity is unclear.

Methods: This was a national population-based study of 55,626 individuals diagnosed with IBD in 1990 to 2016 with longitudinal data on ileocolorectal biopsy specimens followed up through 2016. Serious infections were defined as having an inpatient infectious disease diagnosis in the Swedish National Patient Register.