Interleukin-6 Modulates Endoplasmic Reticulum Stress Signaling and Mitochondrial Protein Complexes in the Kidney Following Acute Exhaustive Exercise.

Endoplasmic Reticulum (ER) homeostasis is closely regulated by an adaptive signaling network identified as the unfolded protein response (UPR), which is tightly related to the inflammatory pathway. However, physical exercise increases plasma concentrations of interleukin-6 (IL-6), which exhibits both pro- and anti-inflammatory properties that mediate ER function and mitochondrial metabolism, making its investigation relevant in physiological and pathological contexts. In kidney diseases, the IL-6 levels are effective in predicting mortality risk.

Epidemiologic aspects and spatial distribution of human visceral leishmaniasis: a cross-sectional study, Crateús, 2007-2023.

Objective: To investigate the epidemiological profile and spatial distribution of human visceral leishmaniasis cases in Crateús, Ceará, Brazil, from 2007 to 2023.

Methods: This was a retrospective, descriptive cross-sectional study based on epidemiologic data from the Notifiable Health Conditions Information System regarding human visceral leishmaniasis in Crateús between 2007 and 2023. The variables assessed were sex, age group at the time of diagnosis, race/skin color, education level, HIV coinfection, case outcome, neighborhood of residence, area of residence, and number of deaths per year of notification.

Comparative effectiveness of noninvasive ventilation interfaces in critically ill adults: A systematic review and Bayesian network meta-analysis.

Objectives: To systematically review the effectiveness of different types of interfaces in the treatment of critically ill patients with respiratory failure requiring NIV.

Methods: Parallel randomized controlled trials (RCTs) were identified through a search conducted in the MEDLINE, CENTRAL, EMBASE, and LILACS databases. Review Manager 5 software was used for direct comparisons.

Instruments to Assess Bidirectional Intimate Partner Violence: A Systematic Review.

Intimate partner violence (IPV) is a significant public health issue that affects individuals, families, and society in profound ways. Over the years, research has often shown that such IPV is predominantly one-sided, with men as perpetrators and women as victims. However, more recent studies have revealed that IPV is frequently bidirectional, with both partners potentially being victims, perpetrators, or both.

The influence of diet, age, and obesity on hypothalamic omega-3 fatty acid transporter MFSD2a.

Inflammatory proteins present in the context of obesity influence the general permeability of organic biological barriers, including the blood-brain barrier (BBB). Inflammation alters junction proteins, resulting in increased permeability, and may also influence the response pattern of barrier proteins responsible for intracellular nutrient transport. Focusing on the MFSD2a protein (major facilitator superfamily domain containing 2 A), which is present in the BBB, is an important translocator of omega-3 fatty acid (ω3) from the periphery to the central nervous system (CNS), this study aimed to assess the impact of obesity induced by a high-fat diet (HF) on the MFSD2a modulation in the hypothalamus of mice.

Aging: a possible road toward gut microbiota pathoadaptation.

Laboratory-raised mice live approximately seven times longer and healthier lives compared to their wild counterparts, due to a standardized healthy diet and limited exposure to environmental stressors. Aging is associated with increased inflammation and microbial dysbiosis. Collectively, these influence microbiota evolution and may contribute to the enrichment in pathobiont frequency observed in old age.

Introducing the Emotions-Affect Systems Elicitation (EASEL-3) Index: A New Tool for Measuring Affect Regulation Systems' Activation.

Objective: Although emotions pervade and influence individual and interpersonal functioning and well-being, their nature and taxonomy remain a bone of contention. The 'three-circle' model, comprising three dynamically interacting affect regulation systems (i.e.

Dimensionality and Psychometric Properties of the Emotions-Affect Systems ELicitation (EASEL-3) in Fibromyalgia and the General Population: A Cross-Cultural Study.

Objective: Despite the growing acceptance and use of the evolutionary tripartite model of affect regulation, the lack of a suitable instrument capable of gauging the activation of the threat, drive and soothing systems hinders further advances. The aim of this study was to preliminarily validate the Emotions-Affect Systems ELicitation (EASEL-3)-a novel index used to estimate the activation of the three affect regulation systems. Evaluated were the assessment of its dimensionality, measurement invariance, psychometric properties and construct and nomological validity.

Space-temporal distribution of triatominae (Hemiptera: Reduviidae) in the State of Pará, Brazilian Amazon: Records from the evandro chagas institute over 47 years (1977-2024).

Geoprocessing represents an essential methodology for the spatial and temporal monitoring of populations, playing a strategic role in the vector control of Chagas disease. This cross-sectional, ecological, and retrospective study analyzed the spatiotemporal distribution of triatomines in the State of Pará, Brazilian Amazon, between 1977 and 2024, based on records from the Evandro Chagas Institute. A total of 9593 triatomines were identified, classified into 11 species and 6 genera originating from 83 municipalities.

Autism Spectrum Disorder: Sleep Characteristics in Children and Adolescents, and Their Relationship with Probable Sleep Bruxism, Anxiety, and Cortisol and Melatonin Levels-A Cross-Sectional Study of Children in Brazil.

The study described the sleep characteristics (SC) of children/adolescents with Autism Spectrum Disorder (ASD), and examined their association with medication use, support level, chronotype, probable sleep bruxism (PSB), anxiety, salivary levels of cortisol (SalC) and melatonin (SalM). Methods: Following anamnesis and dental examination, anxiety was assessed using the SCARED questionnaire. The SCs were determined by two age-appropriate questionnaires, and the percentage of negative SCs (%Neg) was recorded.

Mechanisms underlying the interplay between autophagy and the inflammasome in age-related diseases: Implications for exercise immunology.

Aging is a multifactorial process characterized by cellular dysfunction and increased susceptibility to age-related diseases. The interplay between autophagy and inflammasome has emerged as a critical factor influencing the aging process. Autophagy, which is responsible for degrading damaged cellular components, declines with age, leading to the accumulation of dysfunctional organelles and misfolded proteins.

External and internal intensity profiles of older male and female participants during a walking football game.

Background: Walking football (WF) can be used as an impactful activity for healthy aging and decrease the high levels of sedentary behavior among older adults. This study examines the external and internal intensity profiles of male and female participants during a WF tournament, addressing a gap in research on game demands and induced load.

Methods: The study involved 176 players aged 50 + participating in a 40-min, 5v5 WF tournament with unlimited substitutions.

Fibromyalgia and post-traumatic stress disorder: different parts of an elephant?

Post-traumatic stress disorder (PTSD) and fibromyalgia (FM) are prevalent and debilitating conditions, conventionally delineated by distinct symptom profiles: PTSD is typified by intrusive thoughts and avoidance behaviours, while FM is essentially characterised by widespread pain, cognitive disturbances and fatigue. Despite these differences in definition, these disorders share a multitude of clinical features and risk factors, including persistent psychological distress. Furthermore, they often co-occur.

Proteomic Profiling Identifies MARCO in Extracellular Vesicles, as a Potential Biomarker for Leishmaniasis in HIV Co-Infection.

is an intracellular protozoan parasite that causes leishmaniasis, a disease prevalent in 97 countries. Co-infection with HIV increases susceptibility to visceral leishmaniasis (VL), accelerating HIV's progression to AIDS. Managing VL in HIV-infected individuals is challenging due to atypical presentations and limited therapeutic responses, highlighting the need to develop new disease management strategies.

Exhaustive exercise abolishes REV-ERB-α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice.

The circadian-regulated transcriptional repressor REV-ERB-α is a key mediator of skeletal muscle oxidative capacity, enhancing exercise performance when activated. Conversely its global genetic ablation leads to impaired performance. Simultaneously the kynurenine (KYN) pathway, involved in tryptophan degradation, produces neurotoxic metabolites under stress and inflammation, contributing to CNS dysfunction and fatigue.

Influence of Prosthetic Interface and Manufacturing Metal on Mechanical Behavior of Two Extra Narrow Implants.

Purpose: It is still unclear if modifications in prosthetic/implant interface and implant alloy could affect mechanical behavior of extra-narrow implants. The aim of this study was to evaluate the mechanical behavior of two types of 2.9mm in diameter dental implant, by using physical and virtual mechanical testing.

Brazilian Public Health System protocol for the diagnosis, treatment, and clinical monitoring of acute ischemic stroke.

The Brazilian Ministry of Health has issued new recommendations for the management of patients with acute ischemic stroke. The protocol covers aspects related to diagnosis, treatment, and patient monitoring, expanding the available treatment options for patients treated within the Brazilian Public Health System (Sistema Único de Saúde - SUS, in Portuguese). This article discusses some of the recommendations presented in the current Clinical Practice Protocol, aiming to spread awareness of the document's updates and assist healthcare professionals and services in implementing these recommendations.

Chronic Exercise Protects Against Cognitive Deficits in an Alzheimer's Disease Model by Enhancing Autophagy and Reducing Mitochondrial Abnormalities.

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation, autophagic lysosomal pathway (ALP) dysfunction, mitochondrial abnormalities, and neuroinflammation. Physical exercise (PE) protects against AD, but its molecular mechanisms remain unclear. We hypothesize that PE-mediated upregulation of REV-ERBα and TFEB pathways mitigates AD-related dysfunctions.

Role of Native Arbuscular Mycorrhizal Fungi in Modulating Nutrient Subcellular Distribution in Wheat Grown in Mn-Toxic Soil.

Heavy metal toxicity leads to impaired crop growth and reduced crop yields and product quality by disrupting plant nutrient uptake, inhibiting development, inducing oxidative stress, and causing cellular toxicity. Arbuscular mycorrhizal fungi (AMF) can play a crucial role in crops' adaptation to manganese (Mn) toxicity by regulating nutrient uptake and altering subcellular compartmentalization. The present study examines the influence of intact extraradical mycelia (ERMs) from native AMF on wheat () grown in Mn-toxic soil, with a focus on the tissue-specific and subcellular Ca, Mg, P, and Mn distribution.

Efficacy of Nintendo Switch Rehabilitation Program for Older Adults: A Quasi-Experimental Study.

To evaluate the effectiveness of Nintendo Switch videogames in promoting the rehabilitation of institutionalized older adults. This quasi-experimental study with a control group followed Strengthening the Reporting of Observational Studies in Epidemiology guidelines to ensure methodological quality. The study included 27 institutionalized older adults aged 60 or over at risk of falling, with a Performance-Oriented Mobility Assessment (POMA) score of 19-28 points.

Early mobilization after skin graft for burn injury in adults.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of early mobilization after skin graft for burn injury in adults.

Spin Bias in randomized controlled trials of botulinum toxin for bruxism management: a meta-epidemiologic study.

Objective: To perform a quantitative and qualitative analysis of spin bias in randomized clinical trials (RCTs) focusing on botulinum toxin (BTX-A) for managing bruxism.

Study Design And Protocol: This is a meta-epidemiologic study. The protocol was registered on the Open Science Framework.

The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study.

Background: Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbreak control. We aimed to assess the magnitude, specificity, and durability of cross-reactive immune responses elicited by smallpox vaccines and mpox virus infection.

Methods: We did a multicohort observational study involving participants from the USA, Brazil, and Portugal across four groups: Dryvax (first-generation smallpox vaccine) recipients vaccinated 40-80 years ago, JYNNEOS (third-generation smallpox vaccine) recipients vaccinated within the past year, a cohort receiving both vaccines, and patients infected with clade IIb mpox.

An evidence-based care program in a local healthcare setting in Brazil: Experience and impact.

Objective: To provide an overview of the activities and impact of an Evidence-Based Care Program (EBCP) on professionals' decision-making in a large hospital located in São Paulo, Brazil.

Methods: Retrospective descriptive analysis of a hospital EBCP's database (covering a 40-month period), involving data from the studies conducted and an online feedback survey.

Results: Since its inception, the EBCP performed 95 scientific technical reports, including 55 Rapid Systematic Reviews (RSR) and 40 Literature Reviews (LR).

Trihydroxyflavanone isolated from Dipteryx lacunifera Ducke (Fabaceae) as a potential antimalarial drug: An in silico and in vitro approach.

Dipteryx lacunifera is an example of the Brazilian cerrado flora which recently showed promising biological actions, such as antioxidant and antibacterial activities and a potential antimalarial effect. This study evaluated three flavonoids isolated from the fruits kernels of D. lacunifera, 7,3´, 4´-trihydroxyflavone (1), 7,3´,4´-trihydroxyflavanone (2), and (-)-eriodictyol (3).