The Fracture Ankle Implant Review (FAIR) study : a national multicentre retrospective review of practice in implant choice, fixation methods, and outcomes in fixation of the fibula in ankle fractures.

Aims: In fixation of the fibula in ankle fractures, the AO Foundation advocates using a lag screw and one-third tubular neutralization plate for simple patterns. Where a lag screw cannot be placed, bridging fixation is required. A local pilot service evaluation previously identified variance in use of locking plates in all patterns with significant cost implications.

From data to precision: The transformative role of AI and machine learning in modern orthopaedic practice.

Background: Artificial Intelligence (AI) and Machine Learning (ML) are revolutionising orthopaedic surgery by transforming clinical problem-solving into data-driven input-output frameworks. AI allows surgeons and clinicians to analyse problems and offer innovative solutions objectively. It also enables clinicians to view these problems as an input-output continuum rather than an obstacle that needs to be solved from the basic principles upwards.

Innovative transformer neural network for wind density function estimation at different hub heights of turbine.

Accurate estimation of wind power potential is important for resource assessment to install wind turbine. Weibull distribution functions (WDF) have been widely used and it is a function of wind speed (WS). With Turbine hub height WS get changes and it form complex nonlinear equations with WDF.

Knowledge and perception of antibiotic prophylaxis for dental procedures among Nepali dental students: a questionnaire-based study.

Background: Prescribing medication is an essential part of clinical dentistry, particularly concerning the use of antibiotics for acute odontogenic infections, surgical prophylaxis, and care of medically compromised patients. Research on dental students' knowledge and perception of antimicrobial prophylaxis in dental practice is notably lacking in Nepal. This study aims to bridge that gap by assessing the level of understanding among Nepali dental students.

Sports injuries during Kabaddi: a literature review.

Background And Objective: Kabaddi is an athletic contact sport that involves power, aggression, fine mind-body balance, agility, and swift reflexes. Since Kabaddi is a contact sport, athletes face a higher risk of injuries during competition and training. There is a paucity of literature regarding sports injuries during this game.

Comparative analysis of daily global solar radiation prediction using deep learning models inputted with stochastic variables.

Photovoltaic power plant outputs depend on the daily global solar radiation (DGSR). The main issue with DGSR data is its lack of precision. The potential unavailability of DGSR data for several sites can be attributed to the high cost of measuring instruments and the intermittent nature of time series data due to equipment malfunctions.

Deformity Correction and Limb Lengthening in Maffucci Syndrome - A Case Report.

Introduction: ?Maffucci syndrome (MS) is a rare disorder with enchondromatosis associated with multiple hemangiomas in soft tissue and internal organs. Enchondromas in the long bone lead to limb length discrepancy, deformity, and pathological fractures that usually need corrective osteotomies and limb lengthening.

Case Report: A female in her late adolescence with MS presented with significant varus deformity of the distal femur and left lower limb shortening of 11.

Glucose and glutamine drive hepatitis E virus replication.

Viruses have undergone evolutionary adaptations to tune their utilization of carbon sources, enabling them to extract specific cellular substrates necessary for their replication. The lack of a reliable cell culture system and a small-animal model has hampered our understanding of the molecular mechanism of replication of hepatitis E virus (HEV) genotype 1. Our recent identification of a replicative ensemble of mutant HEV RNA libraries has allowed us to study the metabolic prerequisites for HEV replication.

Meningothelial hamartoma of scalp mimicking encephalocele in an infant: A case report and review of literature.

An extremely rare benign lesion of the scalp is reported in a 2-month-old infant. The lesion had been present since birth. On examination, a 3 × 4 cm skin-colored soft mass over the occipital midline area was observed.

Risk assessment of trace elements in vegetables grown in river Yamuna floodplain in Delhi.

Urban agriculture is common in fertile river floodplains of many developing countries. However, there is a risk of contamination in highly polluted regions. This study quantifies health risks associated with the consumption of vegetables grown in the floodplain of the urban river 'Yamuna' in the highly polluted yet data-scarce megacity Delhi, India.

A slight degree of osteoarthritis appears to be present after anterior cruciate ligament reconstruction compared with contralateral healthy knees at a minimum of 20 years: A systematic review of the literature.

Purpose: The aim of the present systematic review was to quantitatively synthesize the best literature evidence regarding osteoarthritis developing after anterior cruciate ligament reconstruction (ACLR), including only studies with a follow-up duration of at least 20 years.

Material And Methods: A systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines on four electronic databases (PubMed, Scopus, EMBASE and Cochrane Library). The outcome measures extracted from the studies were failure rate, subsequent knee surgery on the same knee, radiographic development of osteoarthritis measured with Kellgren-Lawrence, International Knee Documentation Committee (IKDC) radiographic score and Ahlbäck classification.

Quercetin prophylaxis protects the kidneys by modulating the renin-angiotensin-aldosterone axis under acute hypobaric hypoxic stress.

The study presented here aims at assessing the effects of hypobaric hypoxia on RAAS pathway and its components along with mitigation of anomalies with quercetin prophylaxis. One hour prior to hypobaric hypoxia exposure, male SD rats were orally supplemented with quercetin (50 mg/kg BW) and acetazolamide (50 mg/kg BW) and exposed them to 25,000 ft. (7,620 m) in a simulated environmental chamber for 12 h at 25 ± 2 °C.

Evaluation of Ataxia-Telangiectasia Mutated IVS10 Mutation in Breast Cancer Along with Clinicopathological Parameters.

Background: Breast cancer is the most common cancer in women worldwide, with an estimated 2.26 million new cases diagnosed in 2020. The important genes associated include BRCA1, BRCA2, CHEK2, PTEN, TP53, and ataxia-telangiectasia mutated (ATM).

PgxSAVy: A tool for comprehensive evaluation of variant peptide quality in proteogenomics - catching the (un)usual suspects.

Variant peptides resulting from single nucleotide polymorphisms (SNPs) can lead to aberrant protein functions and have translational potential for disease diagnosis and personalized therapy. Variant peptides detected by proteogenomics are fraught with high number of false positives, but there is no uniform and comprehensive approach to assess variant quality across analysis pipelines. Despite class-specific FDR along with ad-hoc filters, the problem is far from solved.

Nevus of Ota: Combination Treatment with Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser and Fractional CO Laser.

Background: Nevus of Ota is a facial dermal melanocytic hamartoma occurring more commonly in Asians. The mainstay of treatment is 1064-nm Q-Switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, which has shown variable results in pigmented skin.

Objective: The aim of this study was to determine whether Q-Switched Nd:YAG laser treatment combined with fractional CO laser is more efficacious than Q-Switched Nd:YAG laser alone.

An Unexpected Finding of Isolated Hydatidosis of the Spleen With Concomitant Visceromegaly in an Elderly Female.

Hydatidosis of the spleen is a rare zoonotic clinical entity. The occurrence of isolated splenic hydatid cysts in the absence of these cysts in any other portion of the body is referred to as primary splenic hydatidosis. It is a rare disorder that accounts for only 2% of the burden of hydatid disease worldwide.

Giant Lipoma of the Arm Masquerading as an Accessory Breast: A Report of a Rare Case.

Accessory breast is an extremely rare condition that develops in 0.4%-6% of females. It is primarily found in the axilla and is frequently misdiagnosed.