Capturing the influx of living systematic reviews: a systematic methodological survey.

Objectives: Living systematic reviews (LSRs) are an emerging type of review that continuously updates as new evidence becomes available. A previous methodological survey conducted in 2021 identified and studied all health-based LSRs. Since then, the landscape has changed, including the on-going accumulation of COVID-19 research and availability of automation tools.

Midazolam for sedation of infants in the neonatal intensive care unit.

Rationale: Proper sedation for neonates undergoing uncomfortable procedures may reduce stress and prevent complications. Midazolam is a short-acting benzodiazepine that is used in neonatal intensive care units. This is an update of a Cochrane review first published in 2003.

From "No Difference" to "Trending": misinterpretation of statistical analysis in animal studies.

The frequentist approach, with its emphasis on statistical significance, remains predominant in animal research. However, the interpretation and reporting practices associated with this approach have not been evaluated in the context of in vivo pharmacology. In this study, 100 recent publications from 5 journals were analyzed.

Analysis of Cochrane systematic reviews: A comprehensive study of impact and influence from 1998 to 2024.

Introduction: Evidence from Cochrane systematic reviews has significantly impacted clinical practices across diverse disciplines and is widely integrated into international guidelines. To date, there are no bibliometric analyses of Cochrane's publications.

Methods: The search encompassed the Scopus database from inception to May 2024, with results limited to studies published by the Cochrane Database of Systematic Reviews.

Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021.

Importance: Nontraumatic subarachnoid hemorrhage (SAH) represents the third most common stroke type with unique etiologies, risk factors, diagnostics, and treatments. Nevertheless, epidemiological studies often cluster SAH with other stroke types leaving its distinct burden estimates obscure.

Objective: To estimate the worldwide burden of SAH.

Bridging knowledge gaps in phytotherapy for a neglected zoonotic disease: Rift valley fever.

This study sought to review the current state of phytotherapy and natural compound research against Rift Valley fever (RVF), a neglected zoonotic disease exacerbated by climate change and globalisation. A comprehensive literature search was conducted in Scopus, PubMed, and Cochrane Database of Systematic Reviews up to February 2025. Studies focusing on phytotherapy or natural compounds for RVF were included and analysed for research trends, geographical distribution, and compounds.

Corrigendum: Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study.

[This corrects the article DOI: 10.3389/fphar.2025.

Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps.

The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms.

Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study.

Background: To develop a rational and standardized traditional Chinese medicine (TCM) good practice recommendation (GPR) methodology model that guides the formulation of recommendations grounded in clinical experience.

Methods: We adopted an exploratory sequential mixed-method to develop a methodology model by coding systematically collected literature on methodology and TCM guidelines related to TCM GPR using a best-fit framework synthesis. Then based on real-world data (published TCM guidelines), saturation tests, structural rationality validation, and discriminability tests were conducted to validate methodology model.

Cochrane reviews' authorship has become more gender-diverse but remains geographically concentrated: a meta-research study.

Objectives: The aim of this study was to examine the distribution of country, region, language, and gender diversity in the authorship of Cochrane reviews and compare it to non-Cochrane systematic reviews.

Study Design And Setting: We retrieved all published articles from the Cochrane Library (until November 6, 2023) using a web crawling technique that extracted prespecified data fields, including publication date, review category, and author affiliations. For comparison, non-Cochrane systematic reviews were identified through PubMed using E-utility calls.

Use of Digital Health Technologies for Dementia Care: Bibliometric Analysis and Report.

Background: Dementia is a syndrome that compromises neurocognitive functions of the individual and that is affecting 55 million individuals globally, as well as global health care systems, national economic systems, and family members.

Objective: This study aimed to determine the status quo of scientific production on use of digital health technologies (DHTs) to support (older) people living with dementia, their families, and care partners. In addition, our study aimed to map the current landscape of global research initiatives on DHTs on the prevention, diagnosis, treatment, and support of people living with dementia and their caregivers.

Appraisal of World Health Organization guidelines for priority infectious diseases with potential to cause public health emergencies.

Objectives: To map and assess the quality of guidelines developed by or in partnership with the WHO on infectious diseases with a high risk of causing public health emergencies.

Study Design: Cross-sectional audit study.

Methods: A search of the WHO website and MAGICapp was conducted to identify guidelines on treatment, management, diagnosis, prevention, and surveillance of the WHO's priority list of diseases.

Emerging Therapeutic Modalities and Pharmacotherapies in Neuropathic Pain Management: A Systematic Review and Meta-Analysis of Parallel Randomized Controlled Trials.

Neuropathic pain (NP) is a chronic condition caused by abnormal neuronal excitability in the nervous system. Current treatments for NP are often ineffective or poorly tolerated. Hence, we reviewed the efficacy and safety of novel drugs or devices that target neuronal excitability in NP patients compared with placebo, sham, or usual care interventions.

Heterologous versus homologous COVID-19 booster vaccinations for adults: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials.

Background: To combat coronavirus disease 2019 (COVID-19), booster vaccination strategies are important. However, the optimal administration of booster vaccine platforms remains unclear. Herein, we aimed to assess the benefits and harms of three or four heterologous versus homologous booster regimens.

Blood Pressure Control Following Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers: Insights from a Triple-Blind, Randomized, Clinical Trial.

Data on substituting one antihypertensive medication with the proper dose of another antihypertensive medication, in certain medical conditions, are scarce. Herein, we present the results of replacing angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) with the calcium channel blocker (CCB) amlodipine, with or without the alpha- and beta-blocker carvedilol, to control high blood pressure in patients with coronavirus disease 2019 (COVID-19). Iranian hypertensive patients with COVID-19 and a history of taking ACEI or ARB were randomized to "continue" and "change" groups.