Publications by authors named "Amanda Sacker"

Article Synopsis
  • Research investigates the link between socioeconomic position (SEP) and the transition between cognitive states, including neurocognitive impairment and mortality risk.
  • The study found significant differences in cognitive state transitions based on SEP, revealing that higher wealth is associated with a greater likelihood of improving cognitive function.
  • Additionally, lower education levels correlate with increased mortality risk following dementia onset, suggesting that socioeconomic factors may influence both cognitive health and longevity.
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Article Synopsis
  • Individuals in out-of-home care during childhood have an increased risk of developing cardiovascular disease in adulthood, with a 51% higher risk compared to those who weren't placed in care.
  • The research pooled results from twelve studies (two published and ten unpublished), involving over 611,000 individuals across multiple countries (US, UK, Sweden, Finland, Australia).
  • The studies were rigorously selected based on specific criteria, and five of them were rated high in methodological quality, ensuring reliable outcomes for the assessment of cardiovascular risks.
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Background: Individuals who were separated from their biological family and placed into the care of the state during childhood (out-of-home care) are more prone to developing selected physical and mental health problems in adulthood, however, their risk of cardiovascular disease (CVD) is uncertain. Accordingly, we pooled published and unpublished results from cohort studies of childhood care and adult CVD.

Methods: We used two approaches to identifying relevant data on childhood care and adult CVD (PROSPERO registration CRD42021254665).

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Background: Children in social care report poor outcomes in many aspects of their later lives. Less is known about differences by ethnicity.

Objective: We examined the health, socio-economic, family and living arrangements across the first three decades of adult life by the intersection of ethnicity (White, Black, South Asian) with social care.

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Article Synopsis
  • Socioeconomic position is linked to inflammation, which may play a role in the connection between socioeconomic inequalities and neurocognitive disorders in older adults. The study used data from the English Longitudinal Study of Ageing (ELSA) to explore this relationship.
  • Researchers found that higher education, occupation, and wealth are associated with a lower risk of cognitive impairment and dementia over time, highlighting the importance of socioeconomic factors on brain health.
  • Inflammatory markers, particularly white blood cells, C-Reactive Protein (CRP), and plasma fibrinogen, were identified as mediators in the relationship between socioeconomic position and cognitive impairment, emphasizing the complex interplay between lifestyle factors, inflammation, and neuroc
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Background: Maternal depression is a major determinant of offspring mental health. Yet, little is understood about how the duration and timing of maternal depression shapes youth risk for depressive symptoms, which if understood could inform when best to intervene. This study aimed to determine how the timing and duration of maternal depression was related to offspring depression in emerging adulthood, and if these associations varied by sex.

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Background: Autism can be diagnosed from 2 years of age, although most autistic people receive their diagnosis later than this after they have started education. Research is required to understand why some autistic children are diagnosed late, and the level and nature of unmet need prior to diagnosis for late-diagnosed children.

Methods: We examined trajectories of emotional, behavioural and social difficulties (EBSDs) across childhood and adolescence, comparing 'earlier-diagnosed' (diagnosed 7 years or younger) with 'late-diagnosed' (diagnosed between 8 and 14 years) autistic children.

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Article Synopsis
  • The study analyzes work-family life courses from ages 16 to 42 in three British birth cohorts (1946, 1958, 1970) using multi-channel sequence analysis and logistic regression to assess psychological distress at ages 42/43 in men and women.
  • It hypothesizes that weaker employment ties and early transitions to partnerships and parenthood increase psychological distress risks, with expectations of this effect intensifying across the cohorts.
  • Findings indicate men and women with weaker long-term job connections experience more psychological distress, largely influenced by early life factors, with teen mothers showing increased distress in later cohorts that remains unexplained.
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Article Synopsis
  • Birth order influences the roles individuals play in their families, which can affect their sexual behaviors and health outcomes.
  • In a study analyzing data from the National Survey of Sexual Attitudes and Lifestyles, it was found that only-child women tend to start having sex later, while middle-child boys often start earlier than first-borns.
  • Early sexual initiation is linked to riskier sexual behaviors and health issues, with the impact being somewhat moderated by siblings serving as confidants about sexuality.
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Changes across education, employment, and family life over the past 20 years challenges the capacity of previously established social role combinations to continue representing the experiences of young men and women born since the late 1980s. Latent class analysis was used to derive patterns of role combinations at ages 25-26 in those growing up in England, using data from 3191 men and 3921 women in the 1970 British Cohort Study (1996) and 3426 men and 4281 women in the Next Steps study born in 1989-90 (2015-16). Role combinations in 1996 were well defined by five patterns across genders: educated, work-oriented, traditional family, fragile family, and slow starters.

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Few have examined how employment is linked to trends in mental health among young adults across economic contexts in more recent years. To better understand the burden of non-employment and mental distress in this age group, this study examines the association of short-term (<1 year) and long-term (1+ year) out-of-work status with mental health across three recessions among young men and women ages 18-34. We report sex-stratified estimates of frequent mental distress (FMD), out-of-work status, and their association through adjusted prevalence ratios across 27 cycles of the U.

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Objectives: To examine if gestational age groups predict the development of social competence difficulties (SCDs) from childhood into mid-adolescence and to assess the mediation by maternal psychological distress during infancy on these trajectories.

Design: Nationally representative population-based birth cohort (UK Millennium Cohort Study).

Participants: 15 821 children born in 2000-2002.

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Objectives: Exposures to adverse events are associated with impaired later-life psychological health. While these associations depend on the type of event, the manner in which associations for different event types depend on when they occur within the life course has received less attention. We investigated associations between counts of adverse events over the life course, and wellbeing and mental health outcomes in older people, according to their timing (age of occurrence), orientation (self or other) and, both their timing and orientation.

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Children with autism spectrum disorder are at increased risk of depression and self-harming behaviours. The question of whether timing of diagnosis of autism spectrum disorder is associated with these consequences in adolescence has not yet been studied. This exploratory study aimed to explore the association between depression and self-harming behaviour in adolescence and the parent-reported timing of diagnosis for autism spectrum disorder using a large population-based cohort in the United Kingdom.

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Background: Children who spend time in non-parental care report worse health later in life on average, but less is known about differences by type of care. We examined whether self-rated health of adults who had been in non-parental care up to 30 years later varied by type of care.

Methods: We used longitudinal data from the office for National Statistics Longitudinal Study.

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Background: The adverse life-long consequences of being looked-after as a child are well recognised, but follow-up periods for mortality risk have mostly ended in young adulthood and mortality suggested to differ by age of placement, gender and cohort in small samples.

Methods: Data on 353,601 Office for National Statistics Longitudinal Study (LS) members during census years 1971-2001, and Cox proportional hazards regression models with time-varying covariates (age as the timescale), were used to examine whether childhood out-of-home care was associated with all-cause mortality until the end of 2013. After adjusting for baseline age and age, gender, born outside the United Kingdom, number of census observations in childhood and baseline census year we tested whether mortality risk varied for those in care by age, gender and baseline census year, by separate assessment of interaction terms.

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Systematic differences in voter turnout limit the capacity of public institutions to address the needs of under-represented groups. One critical question relates to the role of health as a mechanism driving these inequalities. This study explores the associations of self-rated health (SRH) and limitations in everyday activities with voting over the course of adulthood in the 1958 National Child Development Study and the 1970 British Cohort Study.

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This study aimed to identify determinants of a late autism spectrum disorder diagnosis, including diagnoses made 'very late' (i.e., in adolescence), using the Millennium Cohort Study, a nationally representative population-based cohort in the United Kingdom.

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Overcrowding has been regarded as indicating material deprivation and treated as a proxy measure for individual socioeconomic status. Conventionally, 'persons per room' (PPR) has been employed to identify overcrowded households in UK survey data, though the 'bedroom standard' (BS) approach or the 'modified bedroom standard' (MBS) approach has been thought to capture overcrowded households better. Little is known about which overcrowding measure will perform well in regard to construct and face validity.

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Background: Evidence suggests social media use is associated with mental health in young people but underlying processes are not well understood. This paper i) assesses whether social media use is associated with adolescents' depressive symptoms, and ii) investigates multiple potential explanatory pathways via online harassment, sleep, self-esteem and body image.

Methods: We used population based data from the UK Millennium Cohort Study on 10,904 14 year olds.

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A large body of literature has shown marked differences in the average levels of resources and child well-being across different family structures. Studies have examined cognitive, educational and behavioural outcomes; less is known about differentials in physical health, and about dynamics in early childhood. Furthermore, up to the present time, less emphasis has been placed on describing the underlying mechanisms relating childhood experiences of family structure to health.

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Internalising and externalising behaviours may have heterogeneous patterns across childhood. Different aspects of young children's proximal family environments may influence these behavioural profiles. Previous studies have used indicators of family instability at one point in time or collapsed several indicators into an index.

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Evidence suggests that health-related behaviours (HRBs) cluster in mid-adulthood and are associated with social circumstances (i.e. economic circumstances, cultural norms, employment relations) at the same age.

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Background: Although the effects of individual-level factors on wellbeing change following work exit have been identified, the role of welfare-state variables at the country level has yet to be investigated.

Methods: Data on 8037 respondents aged 50 years and over in 16 European countries were drawn from the Survey of Health, Ageing and Retirement in Europe (SHARE) and the English Longitudinal Study of Ageing (ELSA). We employed multilevel models to assess determinants of change in wellbeing following work exit, using CASP-12 change scores.

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