Publications by authors named "Amanda E Lam"
Cerebrovascular endothelial cell (EC) subtypes characterized by blood-brain barrier (BBB) properties or fenestrated pores are essential components of brain-blood interfaces, supporting brain function and homeostasis. To date, the origins and developmental mechanisms underlying this heterogeneous EC network remain largely unclear. Using single-cell-resolution lineage tracing in zebrafish, we discover a multipotent vascular niche at embryonic capillary borders that generates ECs with BBB or fenestrated molecular identity.
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- Cancer cell survival and growth are influenced by somatic evolution, which selects specific cell traits in response to changing environments.
- Researchers analyzed lung adenocarcinomas with varied genetic mutations (n=313) and discovered a limited number (376) of mutations under positive selection linked to significant changes in gene expression.
- Key pathways important for cancer cell fitness involve loss of normal tissue functions, with specific genes related to cell cycle, DNA repair, and metabolism showing significant conservation and increased expression in tumors.