Publications by authors named "Alyssa Rust"
Objectives: Leg dystonia in cerebral palsy (CP) is debilitating but remains underdiagnosed. Routine clinical evaluation has only 12% accuracy for leg dystonia diagnosis compared to gold-standard expert consensus assessment. We determined whether expert-cited leg dystonia features could be quantified to train machine learning (ML) models to detect leg dystonia in videos of children with CP.
View Article and Find Full Text PDFObjective: Mouse models of genetic dystonias have demonstrated abnormal striatal cholinergic interneuron excitability, but do not consistently demonstrate subjective dystonic features. To determine whether striatal cholinergic interneuron excitation can cause potentially dystonic motor behaviors, we first determined features correlated specifically with dystonia severity in people and then determined whether these features emerged in mice following striatal cholinergic interneuron excitation.
Methods: Eight movement disorders experts rated dystonia severity in 193 videos of people with cerebral palsy doing a seated task.
Prevalence of Women in Medicine Programs at University-Based Internal Medicine Residency Programs.
South Med J
February 2024
Objective: Women physicians face various forms of inequities during their training process that inhibit them from reaching their full potential. As a response, several academic institutions have established women in medicine (WIM) programs as a support system. Our objective was to investigate the prevalence of WIM programs at university-based Internal Medicine residency programs as of December 2021.
View Article and Find Full Text PDFObjective: To determine how caregivers describe dystonia in people with cerebral palsy (CP).
Methods: In this prospective cohort study, paper surveys were administered to caregivers between September 7, 2021 and October 28, 2021 during CP Center visits at a large tertiary care center. Caregivers were asked to describe involuntary movements triggered by voluntary movement or triggered by tactile stimulation in the people with CP they cared for.
Article Synopsis
- * Research has shown that there is a relationship between variability in leg movement and the severity of leg dystonia in people, and that similar movement issues can be induced in mice through long-term excitation of specific brain cells.
- * The study highlights that chronic stimulation of striatal cholinergic interneurons leads to these movement issues, supporting the idea that targeting these cells could be a potential approach for developing dystonia treatments, emphasizing the importance of early intervention after a brain injury.