Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy: A Meta-Analysis.

Background: The prognostic significance of right ventricular (RV) dysfunction in peripartum cardiomyopathy (PPCM) remains inconsistent across studies.

Objectives: This study aimed to evaluate the association between RV dysfunction at diagnosis and likelihood of left ventricular (LV) systolic function recovery and major adverse outcomes in PPCM.

Methods: We conducted a meta-analysis to identify studies with assessment of RV function, major adverse outcomes, and LV systolic function recovery.

Risk of heart failure and subtypes with biomarker-calibrated protein intake: Women's health initiative cohort study.

Introduction: Heart failure (HF) is a growing epidemic, with risk of HF with preserved ejection fraction (HFpEF) significantly higher in post-menopausal women compared to men. Data on its association with dietary protein intake is limited.

Methods: To study the association of dietary protein intake with risk of HF and its subtypes in post-menopausal women, we included post-menopausal women from Women's Health Initiative's (WHI) HF cohort.

Ipsilateral Safety Wire as Bailout for MANTA Failure in Patients Undergoing Transcatheter Aortic Valve Replacement.

Background: MANTA is an effective vascular closure device (VCD) in patients undergoing transcatheter aortic valve replacement (TAVR); however, the lack of a convenient bailout for device-related vascular complications is a limitation. The objective of this study is to examine the safety and efficacy of ipsilateral safety wire (ISW) as a bailout for MANTA failure in patients undergoing TAVR.

Methods: Our institutional Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy (STS/ACC TVT) registry and EPIC chart system were queried to identify patients who underwent TAVR with MANTA and ISW from July 1, 2022, to June 30, 2023.

Exploring the therapeutic potential of bimodal stimulation for tinnitus.

Background: Tinnitus is the perception of sound without any external acoustic stimuli, affecting over 10% of the population, especially older adults. Current treatments focus on symptom management rather than a complete cure, often providing limited relief.

Objective: To evaluate the efficacy and safety of bimodal neuromodulation therapy for tinnitus, compared to traditional treatment methods.

EHE cell cultures: a platform for mechanistic and therapeutic investigation.

Epithelioid hemangioendothelioma (EHE) is a difficult to treat vascular sarcoma defined by TAZ- CAMTA1 or YAP-TFE3 fusion proteins. Human cell lines needed to further understand the pathogenesis of EHE have been lacking. Herein, we describe a method to generate EHE extended primary cell cultures.

Frequency and Associations of Binge-Eating Behavior Patterns With Gastrointestinal Symptoms: A Cross-Sectional Study.

Background and aim Binge-eating behavior (BED) poses a significant public health issue worldwide, as it has severe implications for both the physical and gastrointestinal symptoms. The present study evaluated the prevalence of BED with these symptoms. Furthermore, we assessed the correlation between binge eating and gastrointestinal symptoms.

Antecedents of Patient Loyalty: Exploring Mediating and Moderating Paradigms in Public Hospitals.

Purpose: Countries around the world acknowledge the vital role of effective healthcare services in fostering economic, social, and human development. Consequently, many are striving to enhance their medical facilities. This study specifically examines public hospitals in Pakistan and aims to create a framework for evaluating patient loyalty.

PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted.

Purpose: Sarcomas are a heterogeneous group of cancers with few shared therapeutic targets. PI3K signaling is activated in various subsets of sarcomas, representing a shared oncogenic signaling pathway. Oncogenic PI3K signaling has been challenging to target therapeutically.

Assessing the performance of ChatGPT in medical ethical decision-making: a comparative study with USMLE-based scenarios.

Introduction: The integration of artificial intelligence (AI) into healthcare introduces innovative possibilities but raises ethical, legal and professional concerns. Assessing the performance of AI in core components of the United States Medical Licensing Examination (USMLE), such as communication skills, ethics, empathy and professionalism, is crucial. This study evaluates how well ChatGPT versions 3.

Management of Mandibular Condylar Fractures: A Comparison of Closed versus Open Reduction.

Objective: To compare the closed reduction approach with open reduction (transparotid approach) in the management of condylar fractures for parameters such as postoperative facial nerve injury, trismus, and malocclusion.

Study Design: An analytical comparative study. Place and Duration of the Study: Department of Oral and Maxillofacial Surgery, The Armed Forces Institute of Dentistry, Rawalpindi, Pakistan, from 10th January 2022 to 1st October 2023.

Sero-Positive Isolated Ocular Myasthenia Gravis.

Ocular myasthenia gravis (OMG) is a neuromuscular disease characterized by the production of autoantibodies against post-synaptic proteins at the neuromuscular junction (NMJ). An 18-year-old male who had symptoms of drooping eyelids and double vision was diagnosed with ocular myasthenia gravis on investigations and examinations. Treatment was initiated with a tablet of pyridostigmine 60 mg twice daily per oral for two weeks, followed by three times daily for four weeks.

Determination of the electron temperature and electron density in reduced pressure hydrogen peroxide (H2O2) discharge.

A reduced pressure glow discharge is produced by passing a high-power pulsed DC source of 0-500 W with a frequency of 50 Hz across two parallel disk electrodes. A hydrogen peroxide aqueous solution is used as a flowing gas for discharge generation. Optical emission spectroscopy is employed to diagnose the discharge generated at a reduced pressure of 0.

Exploring Taurine's Potential in Alzheimer's Treatment: A Comprehensive Review.

Alzheimer's disease (AD) stands as one of the predominant neurodegenerative disorders, often culminating in dementia. Taurine, an endogenous amino acid, holds pivotal regulatory functions within the physiological milieu. Emerging evidence suggests that taurine may confer protection against the onset and progression of AD through diverse mechanistic pathways.

Mental Nerve Neurectomy: A Comparison of Titanium Screw Versus Gutta-Percha Oburation of the Mental Foramen.

Objective:  This study aims to compare the two mental foramen obturating techniques in parameters like operator's ease, postoperative displacement of obturation material, and remission of pain after peripheral neurectomy in patients with trigeminal neuralgia.

Study Design:  This study adopts a single-centered comparative analytical approach.

Place And Duration Of Study: This study was performed in the Department of Oral and Maxillofacial Surgery, Armed Forces Institute of Dentistry (AFID), from October 1, 2023, to February 10, 2024.

Exploring the Impact of Social Media Sites on Compulsive Shopping Behavior: The Mediating Role of Materialism.

Purpose: This study aims to examine the influence of social media sites and television advertisements on compulsive shopping behavior, and whether this influence is mediated by materialism in the university students of Saudi Arabia.

Methods: Data was collected from 487 students at Saudi universities. AMOS and Structural equation modeling (SEM) were utilized to examine the data.

Proprotein convertase subtilisn/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and meta-analysis.

Background: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide. Atherosclerosis occurs due to accumulation of low-density lipoprotein cholesterol (LDL-c) in the arterial system. Thus, lipid lowering therapy is essential for both primary and secondary prevention.

Left Coronary Artery to Pulmonary Trunk Fistula: Two Case Reports With Literature Review.

Coronary artery fistulas (CAFs) are abnormal communication between coronary arteries and the pulmonary trunk or with adjacent heart structures. Coronary pulmonary artery fistulas (CPAFs) can be congenital or acquired. Mostly, CAFs are found as incidental findings on angiographic evaluation.

The Mediating Role of Customer Satisfaction between Antecedent Factors and Brand Loyalty for the Shopee Application.

Lately, smartphones have had a significant impact on how individuals act, mainly when they shop. In Malaysia, Shopee is the online shopping website that has garnered the most traffic from e-commerce sites. Shopee Express recognizes the importance of customer happiness and brand loyalty in measuring consumer purchasing behavior for long-term performance.

Comparison Of Different Methods Of Controlling Pain During Debonding Of Orthodontic Brackets.

Objective: To compare the efficacy of finger pressure and plastic wafers in terms of pain control during debonding.

Methods: This cross sectional study was conducted at the Department of Orthodontics, Armed Forces Institute of Dentistry, Rawalpindi, Pakistan, from January to June 2020, and comprised patients of either gender aged 13-21 years who had completed fixed orthodontic treatment with 0.022 brackets of Roth prescription and required debonding.

Bilateral Anteriorly Displaced Microspherophakia in a Female Child With Marfanoid Habitus.

Microspherophakia is a rare congenital anomaly characterized by an abnormally small and spherical crystalline lens, which can be associated with several systemic syndromes. We present an extremely rare case of bilateral anteriorly displaced microspherophakia in a female child with Marfanoid habitus. The patient displayed phenotypic features resembling Marfan syndrome, including tall stature, muscle hypotonia, dolichostenomelia, and increased arm span than body length.

Myopericarditis Following the Third Dose of COVID-19 mRNA Vaccination: A Case Report.

Coronavirus disease 2019 (COVID-19) mRNA vaccine-related cases of pericarditis and myocarditis have been reported infrequently. Most of the patients usually present within a week of the vaccine, and on average, most of the cases were reported after the second dose of vaccine within two to four days. Chest pain was the most common presentation, and fever and shortness of breath were the other commonly reported symptoms.