Paravertebral Block and Perioperative Ketamine in an Opioid-Sparing Analgesia Approach in Video-Assisted Thoracic Surgery: A Retrospective Single-Centre Study.

: Regional anaesthesia techniques allow postoperative pain control while reducing opioid consumption. Ketamine is another viable option for minimising perioperative opioid use. We evaluated the efficacy of a perioperative multimodal analgesia protocol incorporating paravertebral block (PVB) and ketamine infusion in patients undergoing video-assisted thoracic surgery (VATS).

Sex Hormone Profiles in Patients With Torsades de Pointes Ventricular Tachycardia: A Clinical-Electrophysiological Translational Study.

Background: Female sex is a well-recognized risk factor for long QT syndrome and torsades de pointes (TdP), likely reflecting the influence of sex hormones on ventricular repolarization. Overall, estradiol prolongs, whereas progesterone and testosterone shorten, heart rate-corrected QT interval. However, no studies have comprehensively evaluated sex hormone levels in male and female long QT syndrome patients developing TdP, nor their implications in terms of clinical outcomes and electrophysiological changes.

Analysis and Impact of Infection Prevention Procedures in Long-Term Care Facilities.

Background: Healthcare-associated infections (HAIs) are a significant healthcare complication, with major implications for public health. In the EU/EEA, up to 2.6 million new HAIs cases occur annually, causing significant burdens and economic costs.

Prolonged grief disorder in psychiatric patients: Assessing the PG-13-R scale and clinical implications.

Background: Prolonged Grief Disorder (PGD) was recently included in the DSM-5-TR. Although the diagnostic criteria for PGD have been established, its prevalence among psychiatric patients and its implications remain underexplored. This study aimed to determine the rate and characteristics of PGD among psychiatric patients and assess the utility of the PG-13-R scale as a potential predictive screening tool within this population.

Effectiveness of Tildrakizumab 200 mg in Moderate-to-Severe Plaque Psoriasis: A Multicenter Real-World Study Analyzing Patient Outcomes by Weight, PASI, BMI, and Previous Therapies.

Introduction: Psoriasis is a chronic immune-mediated disease with significant systemic implications. Tildrakizumab, an IL-23p19 inhibitor, has demonstrated efficacy in moderate-to-severe plaque psoriasis. Higher doses may be beneficial for patients with elevated body weight or greater disease burden.

A clinical-dermoscopic risk scoring model for early melanoma of the soles: The iDScore_plantar.

Background: Melanoma of the sole is an aggressive rare form, often diagnosed late. Plantar atypical nevi (pAN) are frequently misdiagnosed as plantar early melanomas (pEM) and therefore excised. Our aim was to develop a clinical-dermoscopic risk-scoring model to help discriminate these plantar atypical melanocytic lesions (pAMLs).

Prognostic value of CD47 overexpression measured by flow cytometry in acute myeloid leukemia.

The glycoprotein CD47 is an innate immune checkpoint ubiquitously expressed on all healthy cells to prevent themselves from phagocytosis. CD47 binds to its receptor SIRPα on macrophages, thus producing a signal transduction cascade which inhibits phagocytosis. CD47 is overexpressed on various solid and hematologic malignancies in order to escape the immune system.

Therapeutic Vaccinations with p210 Peptides in Imatinib-Treated Chronic Myeloid Leukemia Patients: 10 Years Follow-Up of GIMEMA CML0206 and SI0207 Studies.

We previously showed that peptides encompassing the unique b3a2 or b2a2 breakpoint amino-acid sequence of oncogenic p210 induced peptide-specific T-cell responses in chronic myeloid leukemia (CML) patients. : From 2007 to 2011, two multicenter peptide vaccine phase II studies, GIMEMA CML0206 and SI0207, enrolling overall 109 CML patients (68 b3a2 and 41 b2a2) with persistence of molecular disease during imatinib treatment, were carried out. Peptide vaccination schedule included the following: "immunization phase" (six vaccinations every 2 weeks); "reinforcement" phase (three monthly boosts) and "maintenance" phase (two boosts at 3-month intervals).

Effectiveness and Safety of Tralokinumab in Atopic Dermatitis: 1-year Results From a Real-world Multicentre Study.

Tralokinumab is a monoclonal antibody selectively targeting IL-13, approved for moderate-to-severe atopic dermatitis (AD), for which real-world data are scarce. This prospective, observational, multicentric study aimed to assess the long-term effectiveness and safety of tralokinumab in patients with AD in a real-world setting. Primary outcomes included 50%, 75%, and 90% improvement in Eczema Area and Severity Index score (EASI50, EASI75, EASI90, respectively) and improvements in Dermatology Life Quality Index (DLQI) at 1 year.

Line-Field Confocal Optical Coherence Tomography: Is One Hour of Training Sufficient for Diagnosing Basal Cell Carcinoma?

Basal cell carcinoma (BCC) is the most common malignancy, characterised by local invasiveness and the potential for tissue destruction. Diagnosing BCC can be challenging, particularly for less experienced dermatologists. Line-field confocal optical coherence tomography (LC-OCT), a new noninvasive optical technique, has become increasingly useful in clinical practice, allowing in vivo imaging at cellular resolution.

Epidemiology of Thyroid Cancer in Tuscany (Central Italy) 2013-2017: Not Just Overdiagnosis.

Thyroid cancer (TC) is the most common endocrine malignancy, and its incidence continues to rise worldwide [...

Efficacy and safety of biologics for hidradenitis suppurativa: A network meta-analysis of phase III trials.

Background: Phase III clinical trials are designed to evaluate the therapeutic effect of drugs and their superiority over other treatment methods, but biologics for hidradenitis suppurativa (HS) have not been compared head-to-head in phase III studies.

Objective: To evaluate the relative efficacy and safety of biologics for HS in a network meta-analysis including available data from phase III trials.

Methods: MEDLINE and Embase were searched for phase III trials investigating the efficacy and/or safety of at least one biologic for moderate-to-severe HS.

The Outcome of Post-Surgical Hip Prosthesis Rehabilitation: Results from a Monocentric Cohort Study.

: With the increase in life expectancy, more patients are undergoing total hip arthroplasty, primarily due to the rising incidence of osteoarthritis. The outcomes of rehabilitation following these surgical interventions are influenced by various factors. This study aims to explore the impact of age, gender, and body mass index (BMI) on pain and functional and rehabilitative outcomes after surgical hip prosthesis rehabilitation.

Eyelid Contact Dermatitis: 25-Year Single-Center Retrospective Study.

: Eyelid dermatitis is an inflammatory disease affecting the palpebral skin characterized by itching, edema, and scaling of the periorbital area. This entity can be a manifestation of various underlying dermatological diseases, but allergic contact dermatitis (ACD) is the predominant etiology of eyelid dermatitis among patients, being diagnosed in 43.4% of cases.

Zoom-in Dermoscopy for Facial Tumors.

: Facial lesions, including lentigo maligna and lentigo maligna melanoma (LM/LMM), both malignant, present significant diagnostic challenges due to their clinical similarity to benign conditions. Although standard dermoscopy is a well-established tool for diagnosis, its inability to reveal cellular-level details highlights the necessity of new magnified techniques. This study aimed to assess the role of standard dermoscopy, high-magnification dermoscopy, and fluorescence-advanced videodermatoscopy (FAV) in diagnosing LM/LMM and differentiating them from benign facial lesions.

Deep Serratus Anterior Plane Block for Multimodal Analgesia in Minimally Invasive Mitral Valve Surgery Performed via Right Anterior Mini-Thoracotomy.

Objective: This study investigated if the serratus anterior plane block (SAPB) within a multimodal analgesia scheme would reduce acute post-operative pain and intravenous opioid consumption in patients admitted to the intensive care unit after isolated minimally invasive mitral valve surgery.

Design: Retrospective study.

Setting: Patients were admitted to the intensive care unit (ICU) of the University Hospital of Siena (Italy).

Correction: Tognetti et al. Pattern Analysis of Benign and Malignant Atypical Melanocytic Skin Lesions of Palms and Soles: Variations of Dermoscopic Features According to Anatomic Site and Personal Experience. 2024, , 659.

"Harald Kittler" was not included as an author in the original publication [...

Ultrasound description of cortical-entheseal bone remodeling in peripheral entheses of patients with psoriasis and nonspecific musculoskeletal symptoms.

Aims: ultrasound (US) diagnosis of enthesitis is burdened of low specificity, especially when it is performed in patients with psoriasis (PsO) but without clinical psoriatic arthritis (PsA), because of mechanical, dysmetabolic and age-related concurrent enthesopatic changes. We propose a novel US score to quantify the cortical-entheseal bone remodeling burden of several peripheral entheses, aiming to improve the specificity of US for PsA-related enthesitis, and to evaluate its diagnostic value in PsO patients with subsequent diagnosis of psoriatic arthritis (PsO/PsA).

Methods: clinical and US data of 119 consecutive patients with moderate/severe PsO and nonspecific musculoskeletal symptoms, were included in this retrospective study.

Line-field confocal optical coherence tomography of basal cell carcinoma: A retrospective study on diagnostic performance.

Introduction: Line-field confocal optical coherence tomography (LC-OCT) represents one of the newest non-invasive in vivo skin imaging techniques. Previous studies described morphologic criteria of basal cell carcinoma (BCC) under LC-OCT examination. Preliminary data on LC-OCT diagnostic performance for BCC have recently been published but showed only a modest improvement compared to dermoscopy, possibly due to study limitations.

Effects of sacubitril/valsartan on renal function and outcome in patients with heart failure and reduced ejection fraction: an Italian cohort study.

Background: Sacubitril/valsartan (S/V) is a cornerstone treatment for heart failure (HF). Beneficial effects on hospitalization rates, mortality, and left ventricular remodeling have been observed in patients with heart failure and reduced ejection fraction (HFrEF). Despite the positive results, the influence of S/V on renal function during long-term follow-up has received little attention.

Non-Invasive Imaging Including Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Diagnosis of Cutaneous Lymphomas.

Primary cutaneous lymphomas (PCL) are a heterogeneous group of non-Hodgkin lymphomas arising from malignant T (CTCL) or B (CBCL) cells, often mimicking other skin conditions. Recently, non-invasive diagnostic imaging modalities, including dermoscopy, Reflectance Confocal Microscopy (RCM), and Line-field Optical Coherence Tomography (LC-OCT), have become increasingly important, supporting clinicians in clinical practice. Hence, our study aimed to describe dermoscopic, RCM, and LC-OCT features of PCL and to explore their role in PCL management.